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    Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites
    13.
    发明申请
    Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites 有权
    用于急性或慢性输送的方法和装置，或用于血管外治疗部位的物质或装置

    公开(公告)号：US20100016836A1

    公开(公告)日：2010-01-21

    申请号：US12567915

    申请日：2009-09-28

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M25/06 ,  A61K35/12

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    14.
    发明授权
    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    将物质或器械急性或慢性传播至血管外治疗部位的方法和装置

    公开(公告)号：US07606615B2

    公开(公告)日：2009-10-20

    申请号：US10458153

    申请日：2003-06-10

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M25/00

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    15.
    发明授权
    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法

    公开(公告)号：US07357794B2

    公开(公告)日：2008-04-15

    申请号：US10466622

    申请日：2002-01-17

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Over-the-wire apparatus and method for open surgery making of fluid connection between two neighboring vessels
    18.
    发明授权
    Over-the-wire apparatus and method for open surgery making of fluid connection between two neighboring vessels 有权
    用于在两个相邻血管之间的流体连接的开放手术的线上设备和方法

    公开(公告)号：US06685716B1

    公开(公告)日：2004-02-03

    申请号：US09478109

    申请日：2000-01-04

    申请人： J. Christopher Flaherty ,  Philip C. Evard

    发明人： J. Christopher Flaherty ,  Philip C. Evard

    IPC分类号： A61B1732

    CPC分类号： A61B17/3207 ,  A61B17/11 ,  A61B17/320016 ,  A61B18/14 ,  A61B2017/00252 ,  A61B2017/1139

    摘要： The invention provides a wire guided aperture creating apparatus, an over-the-wire kit, and a method for creating a hole in adjacent portions of first and second anatomical conduits during a surgical procedure. The apparatus includes an elongated element having a guidewire lumen and an aperture creating assembly disposed near the distal end of the elongated element. In a further embodiment the device may include first and second elongated elements coupled via a coupler and an aperture creating assembly disposed between the elements. At least one of the elements includes a passage-defining element permitting passage therethrough of a first guidewire. In addition to the devices identified above, the kit includes a first guidewire for insertion into a lumen of the first vessel to an initial cutpoint and then through adjacent portions of sidewalls of the first and second vessels into a lumen of the second vessel. The method involves inserting a first guidewire into a lumen of a first vessel to an initial cutpoint and then though adjacent portions of sidewalls of the first vessel and a second vessel into a lumen of the second vessel. The method further involves providing a wire guided aperture creating apparatus as identified above, and inserting the device over the first guidewire such that the passage-defining element passes over the first guidewire.

    摘要翻译： 本发明提供了一种线引导孔产生装置，一种线上套件，以及一种用于在外科手术过程中在第一和第二解剖导管的相邻部分中产生孔的方法。 该装置包括具有导丝管腔的细长元件和设置在细长元件的远端附近的孔产生组件。 在另一实施例中，装置可以包括通过耦合器耦合的第一和第二细长元件以及设置在元件之间的孔产生组件。 元件中的至少一个包括允许第一导丝穿过的通道限定元件。 除了上述识别的装置之外，套件包括用于插入第一容器的内腔到初始切割点的第一导丝，然后通过第一和第二容器的侧壁的相邻部分进入第二容器的内腔。 该方法包括将第一导丝插入第一容器的内腔至初始切割点，然后将第一容器的侧壁的相邻部分和第二容器插入第二容器的内腔。 该方法还包括提供如上所述的线引导孔产生装置，并将装置插入第一导丝上，使得通道限定元件通过第一导丝。

    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    19.
    发明授权
    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法

    公开(公告)号：US08672920B2

    公开(公告)日：2014-03-18

    申请号：US11927888

    申请日：2007-10-30

    申请人： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    发明人： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.

    摘要翻译： 用于将物质或设备运送到位于血管内腔外的靶位置的方法和装置。 将穿透性导管插入血管内腔中，并且穿透器沿导向器朝向目标部位的方向前进。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，输送导管可以保持在适当位置以便从目标部位慢慢或连续地输送物质到和/或获得信息或样品。 或者，具有闭塞构件的输送导管可以推入静脉或小静脉中，并用于在注射物质期间和之后闭塞静脉或小静脉的内腔，使得物质不会被正常的静脉血流带走。