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    Devices, Systems and Methods for Acute or Chronic Delivery of Substances or Apparatus to Extravascular Treatment Sites
    1.
    发明申请
    Devices, Systems and Methods for Acute or Chronic Delivery of Substances or Apparatus to Extravascular Treatment Sites 有权
    用于急性或慢性输送物质或装置用于血管外治疗部位的装置，系统和方法

    公开(公告)号：US20080051756A1

    公开(公告)日：2008-02-28

    申请号：US11927888

    申请日：2007-10-30

    申请人： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    发明人： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    IPC分类号： A61M5/178 ,  A61M31/00

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注入物质期间和之后用于闭塞静脉或小静脉的腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    2.
    发明授权
    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法

    公开(公告)号：US08672920B2

    公开(公告)日：2014-03-18

    申请号：US11927888

    申请日：2007-10-30

    申请人： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    发明人： Joshua Makower ,  Theodore Lamson ,  J. Christopher Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.

    摘要翻译： 用于将物质或设备运送到位于血管内腔外的靶位置的方法和装置。 将穿透性导管插入血管内腔中，并且穿透器沿导向器朝向目标部位的方向前进。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，输送导管可以保持在适当位置以便从目标部位慢慢或连续地输送物质到和/或获得信息或样品。 或者，具有闭塞构件的输送导管可以推入静脉或小静脉中，并用于在注射物质期间和之后闭塞静脉或小静脉的内腔，使得物质不会被正常的静脉血流带走。

    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    4.
    发明申请
    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    将物质或器械急性或慢性传播至血管外治疗部位的方法和装置

    公开(公告)号：US20050090748A1

    公开(公告)日：2005-04-28

    申请号：US10458153

    申请日：2003-06-10

    申请人： Joshua Makower ,  Theodore Lamson ,  J. Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    发明人： Joshua Makower ,  Theodore Lamson ,  J. Flaherty ,  John Reggie ,  John Chang ,  Joseph Catanese ,  David Tholfsen

    IPC分类号： A61M31/00 ,  A61B17/00 ,  A61B17/12 ,  A61B18/24 ,  A61M5/14 ,  A61M25/00 ,  A61M25/01 ,  A61M25/06 ,  A61B8/14

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop
    7.
    发明申请
    Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant having an adjustable bridge stop 审中-公开
    用于重塑心脏瓣膜环的装置，系统和方法，包括使用具有可调节桥接止挡件的桥式植入物

    公开(公告)号：US20080091059A1

    公开(公告)日：2008-04-17

    申请号：US11903407

    申请日：2007-09-21

    申请人： Timothy Machold ,  David Scott ,  David Rahdert ,  David Tholfsen ,  Robert Chang

    发明人： Timothy Machold ,  David Scott ,  David Rahdert ,  David Tholfsen ,  Robert Chang

    IPC分类号： A61F2/02

    CPC分类号： A61B17/0401 ,  A61B17/0057 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623 ,  A61B2017/00876 ,  A61F2/2451 ,  A61F2/2466 ,  A61F2/2487

    摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial adjustability and retrievability years after implant. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize an adjustable bridge stop to secure the implant, and the methods of implantation employ various tools.

    摘要翻译： 植入物或植入物和方法的系统在左心房内或横过左心房施加选定的力向量或力向量的选择组合，这允许二尖瓣小叶更好地适应。 植入物和植入物和方法的植入物或系统使得植入后几年可以快速部署，容易的血管内递送和完全的心房内可调节性和可追溯性。 植入物或植入物和方法的植入物或系统也利用强荧光检查标志。 植入物和植入物和植入物的系统利用可调植入物和固定长度植入物。 植入物和植入物和方法的植入物或系统还可以利用可调节的桥接止挡来固定植入物，并且植入方法使用各种工具。