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1.发明授权Systems and methods for delivering drugs to selected locations within the body 有权将药物运送到身体内的选定位置的系统和方法公开(公告)号：US07094230B2
公开(公告)日：2006-08-22
申请号：US10738226
申请日：2003-12-16
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： An implantable reservoir device (400) including an enclosed membrane (408) on an expandable frame (402) that defines a reservoir (410) and includes a porous region (418). The reservoir device (400) may be deployed and expanded within a blood vessel, and may be filled in situ or prefilled with a drug that passes through the porous region (418). Alternatively, a pair of expandable endovascular blockers (500) may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.
摘要翻译： 一种可植入储存器装置（400），其包括限定储存器（410）并且包括多孔区域（418）的可扩张框架（402）上的封闭膜（408）。 储存装置（400）可以在血管内展开和扩张，并且可以在原位填充或预填充穿过多孔区域的药物（418）。 或者，一对可扩张血管内阻滞剂（500）可以用于分离可以被可被周围组织吸收的药物填充的血管的一部分。
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2.发明授权Systems and methods for delivering drugs to selected locations within the body 有权将药物运送到身体内的选定位置的系统和方法公开(公告)号：US06685648B2
公开(公告)日：2004-02-03
申请号：US09826049
申请日：2001-04-03
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
IPC分类号： A61B814
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： A method is provided for delivering a drug to a selected tissue region within a patient's body with a catheter having a deployable puncturing element, a drug delivery element and an orientation element on a distal portion thereof. The distal portion of the catheter is percutaneously introduced into a blood vessel, and directed endovascularly to a vessel location adjacent to the selected tissue region. The puncturing element is oriented towards the selected tissue region, and deployed to access the selected tissue region. A drug is delivered with the drug delivery element to the selected tissue region.
摘要翻译： 提供了一种用于使用具有可部署穿刺元件，药物递送元件和其远侧部分上的定向元件的导管将药物递送到患者体内的选定组织区域的方法。 导管的远侧部分经皮引入血管，并且血管内定向到与所选择的组织区域相邻的血管位置。 穿刺元件朝向所选择的组织区域定向，并被部署以访问所选择的组织区域。 将药物与药物递送元件一起递送到所选择的组织区域。
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3.发明授权Systems and methods for delivering drugs to selected locations within the body 有权将药物运送到身体内的选定位置的系统和方法公开(公告)号：US08540694B2
公开(公告)日：2013-09-24
申请号：US13338106
申请日：2011-12-27
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. Macaulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. Macaulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： Systems and methods for delivering drugs or other substances to target locations outside of blood vessel lumens or other body lumens. In some embodiments, a catheter having a penetrator is advanced into the body lumen and the penetrator is then advanced from the catheter toward a target location outside of that body lumen. The substance is then delivered through a the penetrator itself or through a delivery catheter that has been advanced through the penetrator to the target location. In other embodiments, the blood vessel or other body lumen is blocked at spaced-apart first and second locations and a quantity of the substance is introduced into the closed-off body lumen between the blocked first and second locations. The substance then diffuses into or through the wall of the vessel or body conduit to reach the target location.
摘要翻译： 将药物或其他物质输送到血管腔或其他体腔外的目标位置的系统和方法。 在一些实施例中，具有穿透器的导管进入体腔，然后穿透器从导管朝向该体腔外侧的目标位置前进。 然后将物质通过穿透器自身或通过穿过穿透器前进到目标位置的输送导管递送。 在其他实施例中，血管或其他体腔在间隔开的第一和第二位置处被阻挡，并且一定量的物质被引入闭合的体腔内被阻塞的第一和第二位置之间。 物质然后扩散入或穿过血管或体导管的壁以到达目标位置。
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4.发明申请Systems and Methods for Delivering Drugs to Selected Locations Within the Body 有权将药物运送到体内所选位置的系统和方法公开(公告)号：US20120172838A1
公开(公告)日：2012-07-05
申请号：US13338106
申请日：2011-12-27
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. Macaulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. Macaulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： Systems and methods for delivering drugs or other substances to target locations outside of blood vessel lumens or other body lumens. In some embodiments, a catheter having a penetrator is advanced into the body lumen and the penetrator is then advanced from the catheter toward a target location outside of that body lumen. The substance is then delivered through a the penetrator itself or through a delivery catheter that has been advanced through the penetrator to the target location. In other embodiments, the blood vessel or other body lumen is blocked at spaced-apart first and second locations and a quantity of the substance is introduced into the closed-off body lumen between the blocked first and second locations. The substance then diffuses into or through the wall of the vessel or body conduit to reach the target location.
摘要翻译： 将药物或其他物质输送到血管腔或其他体腔外的目标位置的系统和方法。 在一些实施例中，具有穿透器的导管进入体腔，然后穿透器从导管朝向该体腔外侧的目标位置前进。 然后将物质通过穿透器自身或通过穿过穿透器前进到目标位置的输送导管递送。 在其他实施例中，血管或其他体腔在间隔开的第一和第二位置处被阻挡，并且一定量的物质被引入闭合的体腔内被阻塞的第一和第二位置之间。 物质然后扩散入或穿过血管或体导管的壁以到达目标位置。
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5.发明授权Systems and methods for delivering drugs to selected locations within the body 失效将药物运送到身体内的选定位置的系统和方法公开(公告)号：US06283951B1
公开(公告)日：2001-09-04
申请号：US09048147
申请日：1998-03-25
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
IPC分类号： A61M25098
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： A transvascular system for delivering a drug to a tissue region from a blood vessel, such as a coronary vein, includes a catheter having a distal portion with puncturing, orientation, drug delivery, and imaging elements. The puncturing element is deployable for penetrating the vessel wall to access the tissue region. The orientation element, e.g. a “cage” including a plurality of struts and/or a radiopaque marker, has a predetermined relationship with the puncturing element, the imaging element detecting the location of the orientation element with respect to the tissue region to orient the puncturing element. The catheter is percutaneously introducing into the vessel, the puncturing element is oriented towards the tissue region, the puncturing element is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device may also be deployed to create a cavity in the tissue region for receiving the drug therein, or an indwelling catheter may be advanced into and left in the tissue region. An implantable reservoir device is also disclosed, including an enclosed membrane on an expandable frame that defines a reservoir and includes a porous region. The reservoir device may be deployed and expanded within a blood vessel, and may be filled in situ or prefilled with a drug that passes through the porous region. Alternatively, a pair of expandable endovascular blockers may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.
摘要翻译： 用于将药物从诸如冠状静脉的血管输送到组织区域的经血管系统包括具有穿刺，取向，药物递送和成像元件的远侧部分的导管。 穿刺元件可展开以穿透血管壁以进入组织区域。 取向元件，例如 包括多个支柱和/或不透射线的标记的“笼”与穿刺元件具有预定的关系，成像元件检测取向元件相对于组织区域的位置以定向穿刺元件。 将导管经皮导入容器中，穿刺元件朝向组织区域定位，穿刺元件展开以接近组织区域，并将药物递送至组织区域。 还可以部署消融装置以在组织区域中形成用于在其中接收药物的空腔，或者留置导管可以进入组织区域并留在组织区域中。 还公开了一种可植入储存器装置，其包括限定储存器并且包括多孔区域的可扩张框架上的封闭膜。 储存器装置可以在血管内展开和扩张，并且可以在原位填充或预填充穿过多孔区域的药物。 或者，一对可扩张血管内阻滞剂可以用于分离可以被可被周围组织吸收的药物填充的血管的一部分。
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6.发明申请Systems and Methods for Delivering Drugs to Selected Locations Within the Body 有权将药物运送到体内所选位置的系统和方法公开(公告)号：US20100324471A1
公开(公告)日：2010-12-23
申请号：US12715252
申请日：2010-03-01
申请人： J. Christopher Flaherty , Joshua Makower , Philip Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： A transvascular system for delivering a drug to a tissue region from a blood vessel includes a catheter having a distal portion with puncturing, orientation, drug delivery, and imaging elements. The puncturing element is deployable for penetrating the vessel wall to access the tissue region. The orientation element has a predetermined relationship with the puncturing element, the imaging element detecting the location of the orientation element with respect to the tissue region to orient the puncturing element. The catheter is percutaneously introduced into the vessel, the puncturing element is oriented towards the tissue region, the puncturing element is deployed to access the tissue region, and the drug is delivered to the tissue region. An ablation device may also be deployed to create a cavity or fluid reservoir in the tissue region for receiving the drug therein, or an indwelling catheter may be advanced into and left in the tissue region.
摘要翻译： 用于将药物从血管输送到组织区域的经血管系统包括具有穿刺，取向，药物递送和成像元件的远侧部分的导管。 穿刺元件可展开以穿透血管壁以进入组织区域。 定向元件与穿刺元件具有预定的关系，成像元件检测取向元件相对于组织区域的位置以定向穿刺元件。 将导管经皮引入容器中，穿刺元件朝向组织区域定向，穿刺元件展开以接近组织区域，并将药物递送至组织区域。 还可以部署消融装置以在组织区域中形成用于在其中接收药物的空腔或流体储存器，或者留置导管可以进入组织区域并留在组织区域中。
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公开(公告)号：US09943401B2
公开(公告)日：2018-04-17
申请号：US12384659
申请日：2009-04-06
申请人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
发明人： Eugene de Juan, Jr. , Cary J. Reich , Stephen Boyd , Yair Alster , David Sierra , Hanson S. Gifford , Jose D. Alejandro , Richard L. Lindstrom , K. Angela Macfarlane , Douglas Sutton , John Anthony Scholl
CPC分类号： A61F2/142 , A61F2/14 , A61F9/00 , A61F2250/0067 , G02C7/047
摘要： A therapeutic lens for the treatment of an epithelial defect comprises a layer of therapeutic material disposed over the stroma and/or Bowman's membrane to inhibit water flow from the tear liquid to the stroma and/or Bowman's membrane, such that corneal deturgescence can be restored to decrease corneal swelling and light scattering. The layer may cover and protect nerve fibers to decrease pain. The layer may comprise an index of refraction to inhibit light scatter from an anterior surface of the stroma and/or Bowman's membrane. The lens may comprise a curved anterior surface that provides functional vision for the patient when the epithelium regenerates. The layer of therapeutic material can be positioned on the eye in many ways, for example with a spray that is cured to adhere the layer to the exposed surface of the stroma and/or Bowman's membrane.
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公开(公告)号：US07783336B2
公开(公告)日：2010-08-24
申请号：US10856489
申请日：2004-05-28
IPC分类号： A61N5/00
CPC分类号： A61B90/39 , A61B6/12 , A61B8/0833 , A61B2090/3925 , A61B2090/3954 , A61B2090/3995
摘要： A marking device for identifying a subcutaneous biopsy cavity having a first nonabsorbable marker element detectable by a first imaging modality and a second nonabsorbable marker element detectable by a second imaging modality but not detectable by the first imaging modality.
摘要翻译： 一种用于识别皮下活检腔的标记装置，其具有可由第一成像模态检测的第一不可吸收标记元件和通过第二成像模态检测但不能被第一成像模态检测的第二不可吸收标记元件。
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公开(公告)号：US09456878B2
公开(公告)日：2016-10-04
申请号：US12777671
申请日：2010-05-11
CPC分类号： A61B90/39 , A61B6/12 , A61B8/0833 , A61B2090/3925 , A61B2090/3954 , A61B2090/3995
摘要： A marking device for identifying a subcutaneous biopsy cavity having a first nonabsorbable marker element detectable by a first imaging modality and a second nonabsorbable marker element detectable by a second imaging modality but not detectable by the first imaging modality.
摘要翻译： 一种用于识别皮下活检腔的标记装置，其具有可由第一成像模态检测的第一不可吸收标记元件和通过第二成像模态检测但不能被第一成像模态检测的第二不可吸收标记元件。
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公开(公告)号：US20130070200A1
公开(公告)日：2013-03-21
申请号：US13503842
申请日：2010-10-25
申请人： Eugene de Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人： Eugene de Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
CPC分类号： G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
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