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公开(公告)号：US20060157413A1
公开(公告)日：2006-07-20
申请号：US10526498
申请日：2003-09-04
申请人： Bernard Bene , Georges Vantard , Carl Reitz
发明人： Bernard Bene , Georges Vantard , Carl Reitz
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1617 , A61M2205/3317 , A61M2205/3324 , A61M2205/52 , A61M2230/65
摘要： It is disclosed a controller for a blood treatment equipment comprising at least a treatment unit including a semipermeable membrane separating the treatment unit in a first compartment for the circulation of blood and in a second compartment for the circulation a of a treatment liquid; the controller is adapted to receive one or more entries of measured information measured during the course of a treatment procedure, calculate from said measured information a value of at least a significant parameter indicative of the progress of an extracorporeal blood treatment carried out by the equipment, wherein the controller is also adapted to compare said calculated significant parameter to at least a prescribed reference value for the same parameter, and to generate at least one output control signal responsive to said comparison for automatically controlling one or more operations performed by the equipment. The invention relates also to an equipment comprising the controller and to a control method the controller can be programmed to carry out.
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12.发明授权Device and method for controlling the balance of fluids in an extracorporeal blood circuit 失效用于控制体外血液回路中流体平衡的装置和方法
公开(公告)号：US5470483A
公开(公告)日：1995-11-28
申请号：US215701
申请日：1994-03-21
申请人： Bernard Bene , Nicolas Goux
发明人： Bernard Bene , Nicolas Goux
CPC分类号： A61M1/3441 , A61M1/3437 , A61M1/3603 , A61M1/3413 , Y10S210/929
摘要： A device and method are provided for controlling the balance of fluids during an extracorporeal blood treatment session, according to which treatment, a certain quantity of liquid is withdrawn from the blood which is compensated for by the injection of a substitute liquid into the extracorporeal circuit. A recirculation circuit is provided and pressure is monitored. A pressure deviation within the recirculation circuit reflects a change in the balance between the quantity of liquid withdrawn from the blood and the quantity of liquid injected into the blood, and injection and/or withdrawal rates are altered to obtain a desired balance. The device and method are especially applicable to haemofiltration, haemodiafiltration and plasmapheresis.
摘要翻译： 提供了一种用于在体外血液治疗期间控制流体平衡的装置和方法，根据该装置和方法，从血液中取出一定量的液体，通过将替代液体注射到体外循环来补偿。 提供再循环回路并监测压力。 再循环回路内的压力偏差反映了从血液中取出的液体的量与注入血液的液体的量之间的平衡变化，并且改变注射和/或撤出速率以获得期望的平衡。 该装置和方法特别适用于血液滤过，血液透析和血浆置换。
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13.发明授权Medical apparatus for extracorporeal blood treatment and method for determining a blood parameter value in a medical apparatus thereof 有权用于体外血液处理的医疗装置和用于确定其医疗装置中的血液参数值的方法公开(公告)号：US09002655B2
公开(公告)日：2015-04-07
申请号：US12772651
申请日：2010-05-03
申请人： Bernard Bene
发明人： Bernard Bene
CPC分类号： A61M1/1605 , A61M1/16 , A61M1/1613 , A61M1/3609 , A61M2202/0429 , A61M2205/3303 , A61M2205/3306 , A61M2205/50 , A61M2205/52 , A61M2205/583 , A61M2230/207
摘要： A medical apparatus for extracorporeal blood treatment and a method for determining blood parameter value have been provided. The medical apparatus has a control unit (9) configured for taking from a storage memory (10) a plurality of blood parameter value measures each made through the sensors (8) provided on the bloodline set of each of a machines plurality at different patient treatment sessions; all the blood parameter values relate to the same patient; receiving at least a corresponding laboratory measured value of the same blood parameter relating to the same patient and a laboratory measurement time; determining a correction factor function of a difference between a measured value made though the sensor and a laboratory measured value; obtaining an actual value of said blood parameter by varying at least the last measure made through the sensor by means of the correcting factor.
摘要翻译： 已经提供了体外血液处理用医疗装置和血液参数值的测定方法。 医疗装置具有控制单元（9），其被配置为从存储存储器（10）取出多个血液参数值测量值，所述多个血液参数值测量值通过设置在多个不同患者治疗的多个机器的血液线组上的传感器（8） 会议 所有血液参数值与同一患者相关; 至少接收与同一患者相关的血液参数相应的实验室测量值和实验室测量时间; 确定通过传感器测得的测量值与实验室测量值之间的差值的校正因子函数; 通过至少通过校正因子改变通过传感器进行的最后一个测量来获得所述血液参数的实际值。
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公开(公告)号：US08641656B2
公开(公告)日：2014-02-04
申请号：US12523311
申请日：2007-04-13
申请人： Bernard Bene
发明人： Bernard Bene
IPC分类号： A61M37/00
CPC分类号： A61M1/3656 , A61M1/3653 , A61M1/3655 , A61M1/3658 , G06F19/00 , G06F19/3481 , G16H50/30
摘要： The invention relates to a calculation and control system for the determination of the state of a vascular access of a patient intended to follow successive sessions of extracorporeal blood treatment by extraction and return of the blood via the vascular access, the system comprising: means for determining the value of at least one hemodynamic extracorporeal parameter of the patient for at least two sessions; means for determining the value of the purification effectiveness of the treatment for at least two sessions; programmed means for determining a risk score relating to the state of the vascular access of the patient as a function of at least two values of the hemodynamic extracorporeal parameter and of at least two determined values of the purification effectiveness.
摘要翻译： 本发明涉及一种计算和控制系统，用于通过经由血管通路提取和返回血液来确定旨在跟随体外血液处理的连续阶段的患者的血管通路的状态，所述系统包括：用于确定 至少一次患者的血液动力学体外参数的值至少两次; 用于确定治疗至少两次的净化效力的价值的手段; 用于根据血液动力学体外参数和至少两个确定的净化效力的值的至少两个值来确定与患者的血管通路状态相关的风险评分的程序化手段。
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公开(公告)号：US08512564B2
公开(公告)日：2013-08-20
申请号：US10526498
申请日：2003-09-04
申请人： Bernard Bene , Georges Vantard , Carl W. Reitz
发明人： Bernard Bene , Georges Vantard , Carl W. Reitz
IPC分类号： B01D29/00
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1617 , A61M2205/3317 , A61M2205/3324 , A61M2205/52 , A61M2230/65
摘要： It is disclosed a controller for a blood treatment equipment comprising at least a treatment unit including a semipermeable membrane separating the treatment unit in a first compartment for the circulation of blood and in a second compartment for the circulation a of a treatment liquid; the controller is adapted to receive one or more entries of measured information measured during the course of a treatment procedure, calculate from said measured information a value of at least a significant parameter indicative of the progress of an extracorporeal blood treatment carried out by the equipment, wherein the controller is also adapted to compare said calculated significant parameter to at least a prescribed reference value for the same parameter, and to generate at least one output control signal responsive to said comparison for automatically controlling one or more operations performed by the equipment. The invention relates also to an equipment comprising the controller and to a control method the controller can be programmed to carry out.
摘要翻译： 公开了一种用于血液处理设备的控制器，其包括至少一个处理单元，该处理单元包括将用于血液循环的第一隔室中的处理单元和用于循环处理液体的第二隔室中的分离处理单元的处理单元; 所述控制器适于接收在治疗过程中测量的测量信息的一个或多个条目，从所述测量信息计算至少一个指示由所述设备执行的体外血液处理进展的显着参数的值， 其中所述控制器还适于将所述计算的有效参数与所述相同参数的至少规定的参考值进行比较，并且响应于所述比较生成至少一个输出控制信号，以自动控制由所述设备执行的一个或多个操作。 本发明还涉及包括控制器的设备和控制器可以被编程为执行的控制方法。
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公开(公告)号：US20100145250A1
公开(公告)日：2010-06-10
申请号：US12523311
申请日：2007-04-13
申请人： Bernard Bene
发明人： Bernard Bene
CPC分类号： A61M1/3656 , A61M1/3653 , A61M1/3655 , A61M1/3658 , G06F19/00 , G06F19/3481 , G16H50/30
摘要： The invention relates to a calculation and control system for the determination of the state of a vascular access of a patient intended to follow successive sessions of extracorporeal blood treatment by extraction and return of the blood via the vascular access, the system comprising: means for determining the value of at least one hemodynamic extracorporeal parameter of the patient for at least two sessions; means for determining the value of the purification effectiveness of the treatment for at least two sessions; programmed means for determining a risk score relating to the state of the vascular access of the patient as a function of at least two values of the hemodynamic extracorporeal parameter and of at least two determined values of the purification effectiveness.
摘要翻译： 本发明涉及一种计算和控制系统，用于通过经由血管通路提取和返回血液来确定旨在跟随体外血液处理的连续阶段的患者的血管通路的状态，所述系统包括：用于确定 至少一次患者的血液动力学体外参数的值至少两次; 用于确定治疗至少两次的净化效力的价值的手段; 用于根据血液动力学体外参数和至少两个确定的净化效力的值的至少两个值来确定与患者的血管通路状态相关的风险评分的程序化手段。
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17.发明授权
公开(公告)号：US6123847A
公开(公告)日：2000-09-26
申请号：US137120
申请日：1998-08-20
申请人： Bernard Bene
发明人： Bernard Bene
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/165 , A61M1/3437 , A61M1/3458 , A61M2205/3393
摘要： Dialysis apparatus including:structure (14) for preparing a dialysis liquid containing sodium, comprising structure (18) for regulating the sodium concentration;a dialysis liquid circuit comprising a feed line (12) and a discharge line (13), the feed line (12) having one end connected to the structure (14) for preparing dialysis liquid, and another end which can be connected to a dialyser (1), the discharge line (13) having an end which can be connected to the dialyser (1);structure (9, 10, 12) for infusing a patient with an infusion solution containing sodium and a substance A at determined concentrations [Na.sup.+ ]sol and [A]sol;structure (32) for determining the sodium concentration [Na.sup.+ ]dial of the dialysis liquid so that the patient's body tends towards a desired sodium concentration [Na.sup.+ ]des, as a function of the dialysance D of the dialyser (1) for sodium, of the desired sodium concentration [Na.sup.+ ]des inside the patient's body, of the infusion flow rate Qinf, and of the sodium concentration [Na.sup.+ ]sol of the infusion solution;control structure (32) for driving the structure (18) for regulating the sodium concentration of the dialysis liquid such that this concentration is equal to the determined concentration [Na.sup.+ ]dial.
摘要翻译： 透析装置，包括：用于制备含有钠的透析液的结构（14），其包含用于调节钠浓度的结构（18） 透析液体回路，包括进料管线（12）和排出管线（13），所述进料管线（12）的一端连接到用于制备透析液体的结构（14），另一端可连接到透析器 （1），所述排出管（13）具有可连接到所述透析器（1）的端部; 结构（9,10,12），用于向患者注入含有浓度为[Na +]溶胶和[A]溶胶的钠和物质A的输液; 用于确定透析液的钠浓度[Na +]表盘的结构（32），以使得患者的身体倾向于所需的钠浓度[Na +] des，作为钠透析器（1）的透析度D的函数 输液流量Qinf中的所需钠浓度[Na +] des，输液溶液的钠浓度[Na +]溶液） 用于驱动用于调节透析液的钠浓度的结构（18）的控制结构（32），使得该浓度等于确定的浓度[Na +]表盘。
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18.发明授权
公开(公告)号：US5744031A
公开(公告)日：1998-04-28
申请号：US942460
申请日：1992-09-09
申请人： Bernard Bene
发明人： Bernard Bene
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/165 , A61M1/3458 , Y10S210/929
摘要： An artificial kidney includes measurement structure for measuring at least one physical characteristic of a fresh dialysis liquid and of used liquid. The measurement structure are disposed in a line portion common to a branch circuit to the feeder line of fresh dialysis liquid and to a branch circuit to the discharge line for the used liquid. Occluding structure permit the liquid to circulate exclusively in one or the other branch circuit. Due to this arrangement, it is possible to obtain the value of the physical characteristics of a patient's blood by calculation as frequently as desired, and to adjust the operation of the kidney permanently to a therapeutic objective set by the physician.
摘要翻译： 人造肾包括用于测量新鲜透析液和二手液体的至少一种物理特性的测量结构。 测量结构设置在与新鲜透析液的供给管线的分支电路相同的直线部分中，并配置到用于所使用的液体的排出管线的分支电路。 封闭结构允许液体专门在一个或另一个分支回路中循环。 由于这种安排，可以通过根据需要频繁地计算来获得患者血液的物理特性的值，并且将肾脏的操作永久地调整为由医生设定的治疗目标。
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19.发明授权
公开(公告)号：US5567320A
公开(公告)日：1996-10-22
申请号：US358175
申请日：1994-12-16
申请人： Nicolas Goux , Bernard Bene
发明人： Nicolas Goux , Bernard Bene
CPC分类号： A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1617
摘要： A method for determining a significant parameter (Cb, D, K, Kt/V) of the progress of an extracorporeal blood treatment carried-out using a membrane exchanger, includes the steps of successively circulating three treatment fluids through the exchanger. Each fluid has a characteristic Cd linked to at least one of the significant parameters of the treatment (Cb, D, K, Kt/V). The value of the characteristic in the first fluid upstream of the exchanger is different from the value of the characteristic in the second fluid upstream of the exchanger, the latter being itself different from the value of the characteristic in the third fluid upstream of the exchanger. Two values for each of the three treatment fluids are measured, respectively upstream and downstream of the exchanger, and at least one value of at least one significant parameter of the progress of the treatment (Cb, D, K, Kt/V) is calculated from the measured values.
摘要翻译： 用于确定使用膜交换器进行的体外血液处理进展的显着参数（Cb，D，K，Kt / V）的方法包括以下步骤：通过交换器连续循环三种处理流体。 每种流体具有与至少一种治疗的重要参数（Cb，D，K，Kt / V）连接的特征性Cd。 在交换器上游的第一流体中的特性值与交换器上游的第二流体中的特性值不同，后者本身不同于交换器上游的第三流体中的特性值。 分别在交换器的上游和下游测量三种处理流体中的每一种的两个值，并且计算处理进展（Cb，D，K，Kt / V）的至少一个有效参数的至少一个值 从测量值。
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公开(公告)号：US09144639B2
公开(公告)日：2015-09-29
申请号：US13642404
申请日：2011-04-14
申请人： Georges Vantard , Bernard Bene
发明人： Georges Vantard , Bernard Bene
CPC分类号： A61M1/1656 , A61M1/16 , A61M1/1607 , A61M1/1609 , A61M1/1613 , A61M1/1617 , A61M1/1647 , A61M1/1666 , A61M1/3403 , A61M5/168 , A61M5/16831 , A61M5/172 , A61M5/1723 , A61M2005/1726 , A61M2205/33 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2210/12 , A61M2230/20 , A61M2230/65
摘要： Dialysis apparatus including a blood treatment unit having a dialysate chamber and a blood chamber separated by a semipermeable membrane, a dialysate circuit presenting a supply line and a discharge line connected to the blood treatment unit, a preparation device for preparing a dialysate containing a substance present in the blood too and a regulator regulating the concentration of the substance in the dialysate. A blood circuit to circulate extracorporeal blood through the blood chamber; a controller that determines a value representative of the concentration of the substance in the blood and are programmed for driving the regulator as a function of the determined value representative of the substance concentration in the blood such that the substance concentration in the dialysate tends towards the substance concentration in the blood.
摘要翻译： 包括具有透析液室的血液处理单元和由半透膜隔开的血液室的透析装置，具有与血液处理单元连接的供给管线和排出管线的透析液回路，制备含有物质的透析液的制备装置 在血液中也是调节调节透析液中物质浓度的调节剂。 通过血液室循环体外血液的血液回路; 控制器，其确定表示血液中物质浓度的值，并且被编程为用于驱动调节器作为代表血液中物质浓度的确定值的函数，使得透析液中的物质浓度倾向于物质 血液中的浓度
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