摘要:
Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.
摘要:
Compounds of Formula (I): I in which B, R1, R1a, R2, R3, R4, R5, R6, R7, R10 and R11 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要:
Compounds having the formula I wherein A, m and R1 are herein defined are Hepatitis C virus polymerase inhibitors. Also disclosed are compositions and methods for treating diseases mediated by HCV and for inhibiting hepatitis replication. Also disclosed are processes for making the compounds and synthetic intermediates used in the process
摘要:
The present Application discloses pesticidally active compounds of formula (I):Q(CH.sub.2).sub.a (O).sub.b Q.sup.1 CR.sup.2 =CR.sup.3 CR.sup.4 =CR.sup.5 CXNR.sup.1 R.sup.xor a salt or propesticide thereof, wherein Q is an optionally substituted aromatic monocyclic or fused bicyclic ring system in which at least one ring is aromatic, or Q is a dihalovinyl group or a group R.sup.6 --C=C--where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halo or hydrogen; Q.sup.1 is a 1,2-cyclopropyl ring optionally substituted by one or more groups selected from C.sub.1-3 alkyl, halo, C.sub.1-3 haloalkyl, C.sub.2-3 alkynyl, or cyano; or Q.sup.1 is (CH.sub.2).sub.7 ; a=0 or 1; b=0 or 1; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; X is oxygen or sulphur;R.sup.1 is phenyl optionally substituted by 1-5 substituents chosen from: a) C.sub.1-4 alkyl, C.sub.1-4 alkoxy, phenoxy and methylenedioxy, each optionally substituted by 1 to 5 halo; b) halo, cyano, nitro, formyl, C.sub.1-5 acyl; c) C.sub.2-3 alkynyl, C.sub.2-3 alkenyl, each optionally substituted by 1 to 5 halo; d) a group S(O).sub.n R.sup.7 wherein n=0, 1, 2 and R.sup.7 is C.sub.1-4 alkyl, halo or NR.sup.8 R.sup.9 wherein R.sup.8 and R.sup.9 are independently selected from hydrogen, C.sub.1-4 alkyl and C.sub.1-4 acyl; and a group e) NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 are as defined above; R.sup.X is hydrogen or an optionally substituted C.sub.1-8 alkyl or benzyl group, their preparation, pesticidal compositions containing them and their use against pests.
摘要翻译:本申请公开了式(I)的杀虫活性化合物:Q(CH2)a(O)bQ1 CR2 = CR3 CR4 = CR5 CXNR1Rx或其盐或农药,其中Q是任选取代的芳族单环或稠合双环体系 其中至少一个环是芳族的,或Q是二卤代乙烯基或基团R6-C = C-,其中R6是C1-4烷基,三C1-4烷基甲硅烷基,卤素或氢; Q1是任选被一个或多个选自C 1-3烷基,卤素,C 1-3卤代烷基,C 2-3炔基或氰基的基团取代的1,2-环丙基环; 或Q 1为(CH 2)7; a = 0或1; b = 0或1; R 2,R 3,R 4和R 5相同或不同,至少一个为氢,其余独立地选自氢,卤素,C 1-4烷基或C 1-4卤代烷基; X是氧或硫; R1是任选被1-5个选自下列的取代基取代的苯基:a)C 1-4烷基,C 1-4烷氧基,苯氧基和亚甲二氧基,各自任选被1至5个卤素取代; b)卤素,氰基,硝基,甲酰基,C 1-5酰基; c)C2-3炔基,C2-3烯基,各自任选被1至5个卤素取代; d)基团S(O)n R 7,其中n = 0,1,2且R 7是C 1-4烷基,卤素或NR 8 R 9,其中R 8和R 9独立地选自氢,C 1-4烷基和C 1-4酰基; 和基团e)NR 8 R 9,其中R 8和R 9如上所定义; RX是氢或任选取代的C 1-8烷基或苄基,它们的制备方法,含有它们的杀虫组合物及其对害虫的用途。
摘要:
A process for the manufacture of a printed circuit board is disclosed in which, during the process, conductive tracks 6 are tested for defects 8 relating to their conductivity and any detected defect 8 is repaired by securing a conductive bridge-piece 9 across the defect 8 by a reflow soldering operation. The repair is encapsulated with a protective layer 16 and the manufacturing process, which includes the further application of heat to the circuit board, is continued.
摘要:
Compounds of Formula I and II: I II having the chemical names cis-6-fluoro-8-(3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline and 6-fluoro-8-(trans-3-fluoropiperidin-4-yloxy)-2-(7-(2-methoxyethoxy)imidazo[1,2-a]pyridin-3-yl)quinoline, respectively, and enantiomers and pharmaceutically acceptable salts thereof, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. The compounds of this invention have also been found to be inhibitors of Pim-1.
摘要:
Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1.
摘要:
Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1.
摘要:
The present invention discloses pesticidally active compounds of formula (II) ##STR1## or a salt thereof, wherein Q is an monocyclic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each ring system being optionally substituted, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halogen or hydrogen; R.sup.2, R.sup.3 , R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; and R.sup.1 is selected from hydrogen and C.sub.1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C.sub.1-6 alkoxy and X.sup.1 is hydrogen, fluoro or chloro.
摘要:
A cue tip chalk retention system wherein openings are formed on cue tip surfaces and chalk is rubbed into the openings. The openings are formed with a penetrating device comprising a housing with a cavity containing multiple outwardly extending pin members. The pin members have a base portion secured to the cavity lower region and a free end portion located in the cavity upper region. The free end portion includes an exposed pointed end which is used to cleanly penetrate the cue tip surfaces and form the desired chalk retention openings.