公开(公告)号：US20070270366A1

公开(公告)日：2007-11-22

申请号：US11612904

申请日：2006-12-19

申请人： James Karras ,  Susan Gregory ,  Andrew Watt ,  Jeffrey Crosby

发明人： James Karras ,  Susan Gregory ,  Andrew Watt ,  Jeffrey Crosby

IPC分类号： A61K48/00 ,  C07H21/00

CPC分类号： C12N15/1138 ,  C07H21/02 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/3521

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

公开(公告)号：US20060258610A1

公开(公告)日：2006-11-16

申请号：US11432834

申请日：2006-05-11

申请人： James Karras ,  Jeffrey Crosby ,  Brett Monia ,  Susan Freier

发明人： James Karras ,  Jeffrey Crosby ,  Brett Monia ,  Susan Freier

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6533

CPC分类号： C12N15/113 ,  A61K48/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.

摘要翻译： 本文公开了用于调节STAT6在细胞，组织或动物中的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗与STAT6表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。

公开(公告)号：US20060234972A1

公开(公告)日：2006-10-19

申请号：US11390894

申请日：2006-03-27

申请人： James Karras ,  Kenneth Dobie

发明人： James Karras ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of TARC in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of TARC, airway hyperresponsiveness, and/or pulmonary inflammation.

公开(公告)号：US20060099613A1

公开(公告)日：2006-05-11

申请号：US11223337

申请日：2005-09-09

申请人： C. Bennett ,  Alexander Borchers ,  James Karras

发明人： C. Bennett ,  Alexander Borchers ,  James Karras

IPC分类号： C40B40/08 ,  C12Q1/68

CPC分类号： C12N15/1136 ,  C12N15/1034 ,  Y02P20/582

摘要： A method for identifying one or more genes involved in a phenotype of cells, tissues or organisms, comprising the steps of contacting cells, tissues or organisms which exhibit the phenotype with a library of antisense oligonucleotides and performing a primary phenotypic assay to determine which antisense oligonucleotides in the library attenuate the phenotype. These antisense oligonucleotides correspond to genes involved in the phenotype. The method may be used to identify genes involved in various disease states.

公开(公告)号：US20050215506A1

公开(公告)日：2005-09-29

申请号：US11071788

申请日：2005-03-02

申请人： C. Bennett ,  Thomas Condon ,  Susan Freier ,  James Karras ,  Susan Fitch ,  Ravi Jain ,  Kenneth Dobie

发明人： C. Bennett ,  Thomas Condon ,  Susan Freier ,  James Karras ,  Susan Fitch ,  Ravi Jain ,  Kenneth Dobie

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

CPC分类号： C07H21/02 ,  A61K38/00 ,  C07H21/04 ,  C12N15/1137 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y114/18001 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of tyrosinase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding tyrosinase. Methods of using these compounds for modulation of tyrosinase expression and for diagnosis and treatment of disease associated with expression of tyrosinase are provided

摘要翻译： 提供化合物，组合物和方法用于调节酪氨酸酶的表达。 组合物包含靶向编码酪氨酸酶的核酸的寡核苷酸。 提供了使用这些化合物调节酪氨酸酶表达和诊断和治疗与酪氨酸酶表达相关的疾病的方法

公开(公告)号：US20050101013A1

公开(公告)日：2005-05-12

申请号：US10704263

申请日：2003-11-06

申请人： Susan Freier ,  James Karras

发明人： Susan Freier ,  James Karras

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07K14/47 ,  C12N15/113

CPC分类号： C07K14/4702 ,  C07H21/02 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for modulating the expression of STAT5. The compositions comprise oligonucleotides, targeted to nucleic acid encoding STAT5. Methods of using these compounds for modulation of STAT5 expression and for diagnosis and treatment of diseases and conditions associated with expression of STAT5 are provided.

摘要翻译： 提供化合物，组合物和方法用于调节STAT5的表达。 组合物包含针对编码STAT5的核酸的寡核苷酸。 提供了使用这些化合物调节STAT5表达和用于诊断和治疗与STAT5表达相关的疾病和病症的方法。

公开(公告)号：US20080051359A1

公开(公告)日：2008-02-28

申请号：US11829279

申请日：2007-07-27

申请人： James Karras

发明人： James Karras

IPC分类号： A61K31/7105 ,  A61P35/00 ,  C07H21/02

CPC分类号： C12N15/1135 ,  A61K38/00 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

摘要： Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.

摘要翻译： 提供化合物，组合物和方法用于抑制人STAT3的表达。 组合物包含靶向编码STAT3的核酸的反义寡核苷酸。 提供了使用这些寡核苷酸抑制STAT3表达和促进细胞凋亡的方法。 还提供了治疗与过表达或STAT3的组成型激活相关的疾病，特别是炎性疾病和癌症的方法。

公开(公告)号：US20070161594A1

公开(公告)日：2007-07-12

申请号：US11548657

申请日：2006-10-11

申请人： James Karras ,  Susan Gregory ,  Susan Freier ,  Kenneth Dobie

发明人： James Karras ,  Susan Gregory ,  Susan Freier ,  Kenneth Dobie

IPC分类号： A61K48/00 ,  C07F9/6533 ,  C07H21/02

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

摘要翻译： 本文公开了用于调节细胞，组织或动物中IL-4Rα的表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗与IL 4R-α表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。

公开(公告)号：US20070161593A1

公开(公告)日：2007-07-12

申请号：US11548650

申请日：2006-10-11

申请人： James Karras ,  Susan Gregory ,  Susan Freier ,  William Gaarde ,  Mausumee Guha

发明人： James Karras ,  Susan Gregory ,  Susan Freier ,  William Gaarde ,  Mausumee Guha

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6533

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

公开(公告)号：US20070135364A1

公开(公告)日：2007-06-14

申请号：US10558216

申请日：2004-05-19

申请人： C. Bennett ,  Timothy Vickers ,  James Karras ,  Susan Freier

发明人： C. Bennett ,  Timothy Vickers ,  James Karras ,  Susan Freier

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6533

CPC分类号： C12N15/1138 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3341 ,  Y02P20/582 ,  C12N2310/3525

摘要： Anti sense oligonucleotide compositions which specifically hybridize with nucleic acids encoding B7 proteins, and use of these compositions for inhibiting expression of B7 mRNA.

摘要翻译： 与编码B7蛋白的核酸特异性杂交的反义寡核苷酸组合物，以及这些组合物用于抑制B7 mRNA表达的反义寡核苷酸组合物。