摘要:
A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要:
The integration of a myriad of modern and legacy systems into a unified logical view is provided. Modern software systems are dependent upon the interaction with and extraction of data from a multitude of distributed systems each generally being accessed by unique credentials using proprietary or vendor-specific protocols. Users faced with the extraction and manipulation of data from these disparate sources must manage multiple login accounts, simultaneously run multiple applications for access and manipulation of data from said sources, and develop new or utilize existing tools for correlation and reporting of data. The present invention provides a single-point interface through which multiple, disparate systems interoperate. User security, communications, information management, searching, reporting, logging, and system maintenance can be performed on any of these systems from a single point provided by this invention. In short, this invention allows users to present a tailored view or representation of the underlying systems it integrates, and is built upon an extensible framework that facilitates rapid deployment of new or changes to the existing subsystems it integrates. The IDSM Processor framework provides XML-based interaction with IDSM clients, validation of client-supplied messages, IDSM data store access, and the management of process flow through the system including identification and invocation of versioned service processing logic. Service processing logic is necessarily dependent upon the requirements associated with said service; therefore, design and implementation details are outside the context of this framework document and will be included in service-specific artifacts.
摘要:
A method for suppressing the expression of a selected gene in a cell the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
摘要:
An electrostatic powder spray coating method and apparatus for producing evenly coated continuous films of thermoplastic and thermosetting powders on substrates or parts having electrically conductive geometric complex surfaces enables the use, without the occurrence of "cobwebbing," of significantly higher charging voltages for the spray gun in the spray coating of preheated substrates and parts, thus allowing faster coating lines. The invention features the use of a grounded electrically conductive ring for grounding the ionized field in the powder discharge region of the spray gun.
摘要:
A license plate frame has a pattern formed on a first side. At least one light source is embedded within the license plate frame. A power source is connected to the light source. Light emitted by the light source only escapes from the pattern.
摘要:
A high voltage propellant isolator includes at least two different types of isolator rings or segments, in alternating lateral arrangement, that direct the flow of propellant, such as xenon gas, in a tortuous path through the isolator.
摘要:
This power supply system for a D.C. electrical load, such as an illuminated sign, is normally energized by batteries. A central processing unit monitors the battery voltage and when it falls below a predetermined magnitude, the central processing unit then activates a starter motor which cranks an engine coupled to it. The central processing unit also actuates a valve and fuel pump to pass fuel to the engine. The engine drives an alternator which produces A.C. voltage which is then rectified by aa rectifier to recharge the batteries. When the batteries are fully charged the central processing unit stops the engine. The central processing unit employs a microprocessor chip to control operations of the system.