公开(公告)号：US07744613B2

公开(公告)日：2010-06-29

申请号：US10734547

申请日：2003-12-12

申请人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney A. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

发明人： Richard C. Ewers ,  Vahid Saadat ,  Kenneth J. Michlitsch ,  Chris A. Rothe ,  Rodney A. Brenneman ,  Cang C. Lam ,  Eugene G. Chen

IPC分类号： A61B17/08 ,  A61B17/04

CPC分类号： A61B1/0055 ,  A61B1/00135 ,  A61B1/018 ,  A61B1/2736 ,  A61B1/31 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/062 ,  A61B17/0625 ,  A61B17/0644 ,  A61B17/29 ,  A61B17/295 ,  A61B17/3421 ,  A61B17/3468 ,  A61B17/3478 ,  A61B2017/00269 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2017/00827 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0443 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/06176 ,  A61B2017/0649 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/2943 ,  A61B2017/3445 ,  A61B2017/3488 ,  A61B2090/3614 ,  A61F5/0086

摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

公开(公告)号：US08216253B2

公开(公告)日：2012-07-10

申请号：US12107701

申请日：2008-04-22

申请人： Vahid Saadat ,  Richard C. Ewers ,  Cang C. Lam ,  Robert A. Vaughan ,  Chris Rothe ,  Kenneth J. Michlitsch

发明人： Vahid Saadat ,  Richard C. Ewers ,  Cang C. Lam ,  Robert A. Vaughan ,  Chris Rothe ,  Kenneth J. Michlitsch

IPC分类号： A61B17/00 ,  A61B17/10

CPC分类号： A61F5/0086 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0483 ,  A61B17/0487 ,  A61B17/06 ,  A61B17/06066 ,  A61B17/064 ,  A61B17/08 ,  A61B17/10 ,  A61B17/12013 ,  A61B17/1285 ,  A61B17/29 ,  A61B2017/00867 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0445 ,  A61B2017/0446 ,  A61B2017/045 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0456 ,  A61B2017/0458 ,  A61B2017/0459 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0475 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/081 ,  A61B2017/3488

摘要： Apparatus for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

摘要翻译： 本文描述了用于操纵和固定组织的装置。 在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于 所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。 稳定构件可以适于相对于细长管状构件的纵向轴线成角度。 此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

公开(公告)号：US20120027872A1

公开(公告)日：2012-02-02

申请号：US13174049

申请日：2011-06-30

申请人： Stevan Nielsen ,  Bodo Quint ,  Randolf Von Oepen ,  Kenneth J. Michlitsch ,  Gerd Seibold ,  Tommy Conzelmann ,  Ib Erling Joergensen

发明人： Stevan Nielsen ,  Bodo Quint ,  Randolf Von Oepen ,  Kenneth J. Michlitsch ,  Gerd Seibold ,  Tommy Conzelmann ,  Ib Erling Joergensen

IPC分类号： A61K38/39 ,  A61P17/02 ,  C07K14/78 ,  C01G3/10 ,  A61K33/00 ,  A61K33/34

CPC分类号： A61B17/00491 ,  A61B17/0057 ,  A61B2017/00654 ,  A61B2017/0472

摘要： Apparatus is provided for sealing a vascular puncture by causing a reduction in the circumference of the puncture tract through delivery of a closure agent into tissue surrounding the puncture tract. A resultant inflammatory response and volumetric increase cause the tissue to swell into the puncture tract, thereby sealing it.

摘要翻译： 提供了用于通过将封闭剂递送到穿刺道周围的组织中引起穿刺道周围的减少来密封血管穿刺的装置。 产生的炎症反应和体积增加导致组织溶胀到穿刺道中，从而将其密封。

公开(公告)号：US20110190772A1

公开(公告)日：2011-08-04

申请号：US13078376

申请日：2011-04-01

申请人： Vahid Saadat ,  Jeffery L. Bleich ,  Kenneth J. Michlitsch ,  John E. Ashley

发明人： Vahid Saadat ,  Jeffery L. Bleich ,  Kenneth J. Michlitsch ,  John E. Ashley

IPC分类号： A61B17/56

CPC分类号： A61B17/1659 ,  A61B17/1671

摘要： A device for modifying tissue in a spine may include: a shah having a proximal portion and a distal portion, the distal portion having dimensions which allow h to be passed into an epidural space of the spine and between target and non-target tissues at least one distal force application member extending from the distal portion of the shall and configured to facilitate application of at least one of anchoring force and tensioning force to the shaft; at least one movable tissue modifying member coupled with the shaft at or near its distal portion; at least one drive member coupled with the at least one tissue modifying member to activate the at least one tissue modifying member; and at least one power transmission member coupled with the at least one drive member to deliver power to the at least one drive member.

摘要翻译： 用于修改脊柱中的组织的装置可以包括：具有近端部分和远端部分的髋部，所述远端部分具有允许h至少进入脊柱的硬膜外腔和靶和非靶组织之间的尺寸 从远端部分延伸的一个远端力施加构件应构造成便于将锚固力和张紧力中的至少一个施加到轴上; 至少一个可动组织修改构件，其在远端部分处或其附近与所述轴联接; 至少一个驱动构件与所述至少一个组织修改构件联接以激活所述至少一个组织修改构件; 以及与所述至少一个驱动构件联接的至少一个动力传递构件，以向所述至少一个驱动构件输送动力。

公开(公告)号：US07955340B2

公开(公告)日：2011-06-07

申请号：US10734562

申请日：2003-12-12

申请人： Kenneth J. Michlitsch ,  Vahid C. Saadat ,  Richard C. Ewers ,  Chris Rothe ,  Rodney Brenneman ,  Cang C. Lam ,  Eugene C. Chen

发明人： Kenneth J. Michlitsch ,  Vahid C. Saadat ,  Richard C. Ewers ,  Chris Rothe ,  Rodney Brenneman ,  Cang C. Lam ,  Eugene C. Chen

IPC分类号： A61B17/10 ,  A61B17/08 ,  A61B1/00

CPC分类号： A61B1/0055 ,  A61B1/00135 ,  A61B1/018 ,  A61B1/2736 ,  A61B1/31 ,  A61B17/00234 ,  A61B17/0218 ,  A61B17/0401 ,  A61B17/0469 ,  A61B17/0482 ,  A61B17/0487 ,  A61B17/062 ,  A61B17/0625 ,  A61B17/0644 ,  A61B17/29 ,  A61B17/3421 ,  A61B17/3468 ,  A61B17/3478 ,  A61B2017/00269 ,  A61B2017/003 ,  A61B2017/00353 ,  A61B2017/00827 ,  A61B2017/0404 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0443 ,  A61B2017/0451 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0461 ,  A61B2017/0462 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/061 ,  A61B2017/06176 ,  A61B2017/0649 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/2943 ,  A61B2017/3445 ,  A61B2017/3488 ,  A61B2090/3614 ,  A61F5/0086

摘要： Apparatus and methods are provided for forming a gastrointestinal tissue fold by engaging tissue at a first tissue contact point and moving the first tissue contact point from a position initially distal to, or in line with, a second tissue contact point to a position proximal of the second contact point, thereby forming the tissue fold, and extending an anchor assembly through the tissue fold from a vicinity of the second tissue contact point. Adjustable anchor assemblies; as well as anchor delivery systems, shape-lockable guides and methods for endoluminally performing medical procedures, such as gastric reduction, treatment of gastroesophageal reflux disease, resection of lesions, and treatment of bleeding sites; are also provided.

摘要翻译： 提供了设备和方法，用于通过在第一组织接触点处接合组织并使第一组织接触点从最初远端或与第二组织接触点一致的位置移动到位于第二组织接触点附近的位置来形成胃肠组织折叠 第二接触点，从而形成组织折叠，并且从第二组织接触点的附近延伸锚固组件穿过组织折叠。 可调锚固组件; 以及锚定递送系统，可锁定形状的导管和用于内窥镜执行医学程序的方法，例如胃减压，治疗胃食管反流疾病，切除病变和治疗出血部位; 也提供。

公开(公告)号：US20080172083A1

公开(公告)日：2008-07-17

申请号：US11953816

申请日：2007-12-10

申请人： Ib Erling Joergensen ,  Gerd Seibold ,  Bodo Stefan Josef Quint ,  Kenneth J. Michlitsch ,  Martina Stueven ,  Randolf von Oepen

发明人： Ib Erling Joergensen ,  Gerd Seibold ,  Bodo Stefan Josef Quint ,  Kenneth J. Michlitsch ,  Martina Stueven ,  Randolf von Oepen

IPC分类号： A61M29/00

CPC分类号： A61M25/104 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0069

摘要： Apparatus and methods for providing distal protection during a medical procedure that include a vascular filter having a self-expanding, porous foam body that conformably seals against a vessel wall and captures emboli within one or more recesses. The filter is coupled to a distal region of an elongated member, such as a guide wire. Delivery systems for use with filters of the present invention and methods of using the apparatus of the present invention also are provided.

摘要翻译： 在医疗过程中提供远端保护的装置和方法，其包括血管过滤器，所述血管过滤器具有自膨胀多孔泡沫体，所述自扩张多孔泡沫体适形地密封血管壁并在一个或多个凹部内捕获栓塞。 过滤器联接到诸如导丝的细长构件的远侧区域。 还提供了与本发明的过滤器一起使用的输送系统和使用本发明的装置的方法。

公开(公告)号：US07347863B2

公开(公告)日：2008-03-25

申请号：US10955245

申请日：2004-09-29

申请人： Chris Rothe ,  Richard C. Ewers ,  Cang C. Lam ,  Vahid Saadat ,  Kenneth J. Michlitsch

发明人： Chris Rothe ,  Richard C. Ewers ,  Cang C. Lam ,  Vahid Saadat ,  Kenneth J. Michlitsch

IPC分类号： A61B17/10 ,  A61B17/00 ,  A61B17/08

CPC分类号： A61B1/0014 ,  A61B17/0401 ,  A61B17/06066 ,  A61B17/29 ,  A61B17/295 ,  A61B2017/00867 ,  A61B2017/00876 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0419 ,  A61B2017/0496 ,  A61B2017/06052 ,  A61B2017/06076 ,  A61B2017/3488 ,  A61B2090/037

摘要： Apparatus and methods for manipulating and securing tissue are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. The stabilizing members can be adapted to become angled relative to a longitudinal axis of the elongate tubular member. Moreover, one or all the articulation controls and functions can be integrated into a singular handle assembly connectable to the tissue manipulation assembly via a rigid or flexible tubular body.

摘要翻译： 本文描述了用于操纵和固定组织的装置和方法。 在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，位于 所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。 稳定构件可以适于相对于细长管状构件的纵向轴线成角度。 此外，一个或所有关节运动控制和功能可以集成到通过刚性或柔性管状体连接到组织操作组件的单个手柄组件中。

公开(公告)号：US08425553B2

公开(公告)日：2013-04-23

申请号：US13615551

申请日：2012-09-13

申请人： Kenneth J. Michlitsch

发明人： Kenneth J. Michlitsch

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672

摘要： The apparatus is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

摘要翻译： 该装置用于通过在穿刺管内形成自体塞子并将该塞子挤压到穿刺管中来密封血管穿刺道。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件，以在与血液凝结剂混合期间将抽取的血液与血管隔离，并且便于相对于血管的装置放置。

公开(公告)号：US08398630B2

公开(公告)日：2013-03-19

申请号：US13620173

申请日：2012-09-14

申请人： Denise Demarais ,  Hanson Gifford, III ,  Mark Deem ,  Nicolas Zadno ,  Benjamin J. Clark ,  Andrew Wu ,  Kenneth J. Michlitsch

发明人： Denise Demarais ,  Hanson Gifford, III ,  Mark Deem ,  Nicolas Zadno ,  Benjamin J. Clark ,  Andrew Wu ,  Kenneth J. Michlitsch

IPC分类号： A61B18/12

摘要： Methods and apparatus are provided for non-continuous circumferential treatment of a body lumen. Apparatus may be positioned within a body lumen of a patient and may deliver energy at a first lengthwise and angular position to create a less-than-full circumferential treatment zone at the first position. The apparatus also may deliver energy at one or more additional lengthwise and angular positions within the body lumen to create less-than-full circumferential treatment zone(s) at the one or more additional positions that are offset lengthwise and angularly from the first treatment zone. Superimposition of the first treatment zone and the one or more additional treatment zones defines a non-continuous circumferential treatment zone without formation of a continuous circumferential lesion. Various embodiments of methods and apparatus for achieving such non-continuous circumferential treatment are provided.

公开(公告)号：US08323311B2

公开(公告)日：2012-12-04

申请号：US12853139

申请日：2010-08-09

申请人： Kenneth J. Michlitsch

发明人： Kenneth J. Michlitsch

IPC分类号： A61B17/08

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00659 ,  A61B2017/00672

摘要： The apparatus is provided for sealing a vascular puncture tract by forming the autologous plug within the puncture tract, and extruding that plug into the puncture tract. The apparatus of the present invention forms an autologous blood plug by drawing blood into the apparatus from a vessel, mixing a blood congealing agent with the drawn blood, and ejecting a plug formed from the clotted blood within the puncture tract. Also provided are various closure elements to isolate the drawn blood from the vessel during mixture with the blood congealing agent, and to facilitate placement of the apparatus relative to the vessel.

摘要翻译： 该装置用于通过在穿刺管内形成自体塞子并将该塞子挤压到穿刺管中来密封血管穿刺道。 本发明的装置通过从血管中将血液吸入装置，将血液凝固剂与抽取的血液混合，并在穿刺管内喷出由凝血血液形成的塞子，形成自体血栓。 还提供了各种封闭元件，以在与血液凝结剂混合期间将抽取的血液与血管隔离，并且便于相对于血管的装置放置。