公开(公告)号：US20170183630A1

公开(公告)日：2017-06-29

申请号：US15457956

申请日：2017-03-13

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: C12N5/071

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

公开(公告)号：US09593310B2

公开(公告)日：2017-03-14

申请号：US14840297

申请日：2015-08-31

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: C12N5/00 ,  C12N5/071

CPC classification number: C12N5/0676 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/40 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/70 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2533/90

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

Abstract translation: 本发明提供促进多能干细胞分化成胰岛素生成细胞的方法。 特别地，本发明提供了一种产生表达特征性胰岛内分泌谱系特异性标志物的方法，其共表达NKX6.1和胰岛素和最小量的胰高血糖素。

公开(公告)号：US11708562B2

公开(公告)日：2023-07-25

申请号：US16598920

申请日：2019-10-10

Applicant: Janssen Biotech, Inc.

Inventor： Alireza Rezania ,  Jean Xu

IPC: C12N5/071 ,  A61K35/39

CPC classification number: C12N5/0676 ,  A61K35/39 ,  C12N5/067 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2501/42 ,  C12N2501/70 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2533/90

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.

公开(公告)号：US20230151332A1

公开(公告)日：2023-05-18

申请号：US18099852

申请日：2023-01-20

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: C12N5/071

CPC classification number: C12N5/0676 ,  C12N2501/16 ,  C12N2501/40 ,  C12N2501/41 ,  C12N2501/70 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/385 ,  C12N2501/415 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2533/90

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

公开(公告)号：US20200291360A1

公开(公告)日：2020-09-17

申请号：US16892106

申请日：2020-06-03

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: C12N5/071

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

公开(公告)号：US10704025B2

公开(公告)日：2020-07-07

申请号：US15457956

申请日：2017-03-13

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: C12N5/071

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

公开(公告)号：US10471104B2

公开(公告)日：2019-11-12

申请号：US16134831

申请日：2018-09-18

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: A61K35/39

Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.

公开(公告)号：US20200030383A1

公开(公告)日：2020-01-30

申请号：US16582279

申请日：2019-09-25

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: A61K35/39 ,  C12N5/071

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.

公开(公告)号：US20160032250A1

公开(公告)日：2016-02-04

申请号：US14840297

申请日：2015-08-31

Applicant: Janssen Biotech, Inc.

Inventor： Jean Xu

IPC: C12N5/071

CPC classification number: C12N5/0676 ,  C12N2501/117 ,  C12N2501/119 ,  C12N2501/16 ,  C12N2501/385 ,  C12N2501/40 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2501/70 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2533/90

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express NKX6.1 and insulin and minimal amounts of glucagon.

Abstract translation: 本发明提供促进多能干细胞分化成胰岛素生成细胞的方法。 特别地，本发明提供了一种产生表达特征性胰岛内分泌谱系特异性标志物的方法，其共表达NKX6.1和胰岛素和最小量的胰高血糖素。