-
公开(公告)号：US11890304B2
公开(公告)日：2024-02-06
申请号：US16582279
申请日：2019-09-25
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
CPC classification number: A61K35/39 , C12N5/0676 , C12N2500/34 , C12N2501/115 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/21 , C12N2501/23 , C12N2501/335 , C12N2501/385 , C12N2501/40 , C12N2501/415 , C12N2501/42 , C12N2501/70 , C12N2501/999 , C12N2506/02 , C12N2533/90
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
-
公开(公告)号：US20200048614A1
公开(公告)日：2020-02-13
申请号：US16598920
申请日：2019-10-10
Applicant: Janssen Biotech, Inc.
Inventor： Alireza Rezania , Jean Xu
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
-
公开(公告)号：US20240002807A1
公开(公告)日：2024-01-04
申请号：US18210821
申请日：2023-06-16
Applicant: Janssen Biotech, Inc.
Inventor： Alireza Rezania , Jean Xu
CPC classification number: C12N5/0676 , C12N5/067 , A61K35/39 , C12N2501/115 , C12N2501/16 , C12N2501/385 , C12N2501/727 , C12N2501/70 , C12N2506/02 , C12N2533/90 , C12N2501/119 , C12N2501/42 , C12N2501/415
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
-
4.发明申请公开(公告)号：US20230061503A1
公开(公告)日：2023-03-02
申请号：US17740665
申请日：2022-05-10
Applicant: Janssen Biotech, Inc. , Legend Biotech USA Inc.
Inventor： Muhammad S. AKRAM , Kevin C. De Braganca , Jenna Goldberg , Carolyn Chang Jackson , Erin C. Lee , Nikoletta Lendvai , Maria Marquez de Mondelo , Yunsi Olyslager , Jun Qiu , Enrique Zudaire Ubani , Jean Xu
IPC: A61K35/17 , A61P35/00 , A61K31/573 , A61K45/06 , G01N33/68
Abstract: The present disclosure relates to methods of early identification and detection of neurotoxicity associated with the administration of chimeric antigen receptor (CAR) T cell therapy and mitigation strategies to reduce the occurrence and/or severity of treatment associated neurotoxicity.
-
公开(公告)号：US20220296653A1
公开(公告)日：2022-09-22
申请号：US17830739
申请日：2022-06-02
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: A61K35/39
Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
-
Patent Agency Ranking
公开(公告)号：US20190030086A1
公开(公告)日：2019-01-31
申请号：US16134831
申请日：2018-09-18
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: A61K35/39
CPC classification number: A61K35/39
Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
-
公开(公告)号：US20170327793A1
公开(公告)日：2017-11-16
申请号：US15669461
申请日：2017-08-04
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: C12N5/071 , A61K35/12 , C12N5/0735
CPC classification number: C12N5/0678 , A61K35/12 , A61K35/545 , A61P3/10 , C12N5/0606 , C12N5/0676 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/727 , C12N2501/998 , C12N2506/02
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells expressing markers characteristic of the pancreatic endoderm lineage, wherein greater than 50% of the cells in the population co-express PDX1 and NKX6.1.
-
公开(公告)号：US11369642B2
公开(公告)日：2022-06-28
申请号：US16539401
申请日：2019-08-13
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: A61K35/39
Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
-
公开(公告)号：US20200030382A1
公开(公告)日：2020-01-30
申请号：US16539401
申请日：2019-08-13
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
IPC: A61K35/39
Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
-
公开(公告)号：US10456424B2
公开(公告)日：2019-10-29
申请号：US15660885
申请日：2017-07-26
Applicant: Janssen Biotech, Inc.
Inventor： Jean Xu
Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells. The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer.
-
-
-
-
-
-
-
-
-
Search Results
19
records
(took 0.025 seconds)
