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公开(公告)号：US20100093709A1
公开(公告)日：2010-04-15
申请号：US12622548
申请日：2009-11-20
申请人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/5415 , C07D413/02 , C07D413/14 , C07D417/14 , A61K31/538
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环δ-阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20090264474A1
公开(公告)日：2009-10-22
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/4439 , C07D333/66 , A61K31/381 , C07D417/12 , C07D409/12 , A61K31/4196 , A61K31/427 , C07D401/14
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US20080318937A1
公开(公告)日：2008-12-25
申请号：US12196865
申请日：2008-08-22
申请人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steven J. Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： A61K31/5415 , C07D417/14 , C07D413/14 , A61K31/538 , A61P25/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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公开(公告)号：US20100015053A1
公开(公告)日：2010-01-21
申请号：US12500334
申请日：2009-07-09
IPC分类号： A61K51/04 , C07D333/66 , C12Q1/02 , C07C29/14
CPC分类号： A61K51/0431
摘要： The present invention is directed to radiolabelled ligands, useful for the labeling and imaging of TRP M8 (transient receptor potential M8 channel) functionality. The present invention is further directed to pharmaceutical compositions comprising the radiolabelled ligands and methods for the preparation of the radiolabelled ligands.
摘要翻译： 本发明涉及用于标记和成像TRP M8（瞬时受体电位M8通道）功能的放射性标记的配体。 本发明还涉及包含放射性标记的配体的药物组合物和用于制备放射性标记的配体的方法。
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公开(公告)号：US20090298867A1
公开(公告)日：2009-12-03
申请号：US12536635
申请日：2009-08-06
申请人： John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
发明人： John R. Carson , Ellen Codd , Christine M. Razler , Andrea Works , Mark McDonnell , James J. McNally
IPC分类号： A61K31/46 , C07D451/02 , A61P29/00
CPC分类号： C07D405/04 , C07D405/14 , C07D409/14 , C07D471/08
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
摘要翻译： 本发明涉及Δ阿片样物质受体调节剂。 更具体地，本发明涉及三环类阿片样物质调节剂。 还描述了使用本发明的化合物治疗轻度至重度疼痛和各种疾病的药物和兽医组合物和方法。
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16.发明申请公开(公告)号：US20080300236A1
公开(公告)日：2008-12-04
申请号：US12174017
申请日：2008-07-16
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： A61K31/47 , C07D215/38 , A61K31/55 , A61P9/00 , A61P25/00 , C07D401/14
CPC分类号： C07D215/38 , C07D215/60 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/10
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的喹啉衍生的酰胺，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。
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公开(公告)号：US07439239B2
公开(公告)日：2008-10-21
申请号：US11313635
申请日：2005-12-21
申请人： Steve Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
发明人： Steve Coats , Scott L. Dax , Bart DeCorte , Li Liu , Mark McDonnell , James J. McNally
IPC分类号： C07D413/08 , C07D413/14 , A61K31/538
CPC分类号： C07D451/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases and conditions, including pain. Such compounds are represented by Formula I as follows: wherein A, G, Y, R3-R5 are defined herein.
摘要翻译： 公开了用于治疗各种疾病和病症（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，G，Y，R 3〜R 5在本文中定义。
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公开(公告)号：US06984647B2
公开(公告)日：2006-01-10
申请号：US10438477
申请日：2003-05-15
IPC分类号： A61K31/47 , C07D211/06 , C07D217/22
CPC分类号： C07D213/40 , C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2601/02 , C07C2602/10 , C07D215/38 , C07D217/02 , C07D217/08 , C07D217/22 , C07D217/24 , C07D233/64 , C07D237/28 , C07D239/74 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/32 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
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19.发明授权Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful as platelet aggregation inhibitors 失效用作血小板聚集抑制剂的取代的噻唑基氨基四氢吡啶并嘧啶衍生物
公开(公告)号：US5405848A
公开(公告)日：1995-04-11
申请号：US171581
申请日：1993-12-22
IPC分类号： C07D471/04 , A61K31/425 , C07D413/00 , C07D471/00
CPC分类号： C07D471/04
摘要： This invention relates to substituted thiazolylaminotetrahydropyridopyrimidines derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients.
摘要翻译： 本发明涉及以下通式的取代的噻唑基氨基四氢吡啶并嘧啶衍生物，其取代基如本说明书中所定义：这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并且可以在药物组合物中提供 以及治疗患者再灌注血栓形成的方法。
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公开(公告)号：US08569505B2
公开(公告)日：2013-10-29
申请号：US12692128
申请日：2010-01-22
申请人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
发明人： Ellen Codd , Scott L. Dax , Michele Jetter , Mark McDonnell , James J. McNally , Mark Youngman
IPC分类号： C07D217/02 , C07C275/28
CPC分类号： C07C275/26 , C07C275/28 , C07C275/32 , C07C335/14 , C07C2602/10 , C07D217/02 , C07D217/08
摘要： This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.
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