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11.发明申请SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS 有权取代的二氢吡咯烷酮及其作为HIF-PROLYL-4-羟基酶抑制剂的用途公开(公告)号：US20120264704A1
公开(公告)日：2012-10-18
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/506 , C07D417/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/517 , A61K31/501 , A61K31/4709 , A61K31/497 , A61K31/55 , A61P7/10 , A61K31/616 , A61P31/04 , A61P35/00 , A61K31/7048 , A61P9/00 , A61P7/06 , A61P13/12 , C07D471/04 , A61K31/498 , A61K31/714 , C07D401/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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公开(公告)号：US08609698B2
公开(公告)日：2013-12-17
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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13.发明授权Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors 有权取代的二氢吡唑酮及其作为HIF-脯氨酰基-4-羟化酶抑制剂的用途公开(公告)号：US08524699B2
公开(公告)日：2013-09-03
申请号：US12447201
申请日：2007-10-26
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/501 , A61K31/4965 , A61K31/4725 , A61K31/4427 , A61K31/55 , C07D413/14 , C07D487/12 , C07D403/14 , C07D401/14 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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14.发明授权Substituted dihydropyrazolones for treating cardiovascular and hematological diseases 有权取代二氢吡唑酮用于治疗心血管和血液疾病公开(公告)号：US08653111B2
公开(公告)日：2014-02-18
申请号：US13356256
申请日：2012-01-23
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/4439 , C07D401/14
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新型取代的二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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15.发明申请SUBSTITUTED DIHYDROPYRAZOLONES FOR TREATING CARDIOVASCULAR AND HEMATOLOGICAL DISEASES 有权用于治疗心血管和血液病的替代二氢吡咯烷酮公开(公告)号：US20100305085A1
公开(公告)日：2010-12-02
申请号：US12447192
申请日：2007-10-12
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Joachim Schuhmacher , Hanno Wild , Peter Kolkhof , Hartmut Beck , Jörg Keldenich , Metin Akbaba , Mario Jeske
IPC分类号： A61K31/397 , C07D401/14 , A61K31/4439 , C07D413/14 , A61K31/5377 , A61K31/4545 , C07D403/14 , A61K31/506 , A61P9/00 , A61P13/12
CPC分类号： C07D487/04 , A61K31/427 , A61K31/4439 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： The invention relates to dihydropyrazolon-derivatives of formula (I), to methods for their production, to their use for treating and/or for preventing diseases and their use for producing medicaments for treating and/or for preventing diseases, in particular cardiovascular and haematological diseases, kidney diseases and for promoting the healing of wounds.
摘要翻译： 本发明涉及式（I）的二氢吡唑酮衍生物，其生产方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，特别是心血管和血液学 疾病，肾脏疾病和促进伤口愈合。
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公开(公告)号：US20100093803A1
公开(公告)日：2010-04-15
申请号：US12447207
申请日：2007-10-16
申请人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
发明人： Kai Thede , Ingo Flamme , Felix Oehme , Jens-Kerim Ergüden , Friederike Stoll , Hanno Wild , Peter Kolkhof , Hartmut Beck , Mario Jeske
IPC分类号： A61K31/444 , C07D401/14
CPC分类号： C07D401/14
摘要： The present application relates to novel substituted dipyridyldihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
摘要翻译： 本申请涉及新的取代二吡啶基二氢吡喃酮衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病，特别是心血管和血液疾病和肾脏的药物的用途 疾病和促进伤口愈合。
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17.发明申请Quinoxalinones and their use especially in the treatment of cardiovascular diseases 审中-公开喹喔啉酮及其用途特别用于治疗心血管疾病公开(公告)号：US20060247244A1
公开(公告)日：2006-11-02
申请号：US10503521
申请日：2003-01-27
申请人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
发明人： Jens-Kerim Ergüden , Peter Kolkhof , Julio Castro-Palomino , Alexander Kuhl , Raimund Kast , Johannes-Peter Stasch , Hanna Tinel , Klaus Münter , Klemens Lustig , Josef Pernerstorfer , Martin Bechem , Jörg Hüser
IPC分类号： A61K31/498 , C07D241/36
CPC分类号： C07D403/12 , C07D241/44 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to quinoxalinones and to methods for producing the same as well as the use thereof for preparing drugs for the treatment and/or prophylaxis of diseases, especially of cardiovascular diseases.
摘要翻译： 本发明涉及喹喔啉酮及其制备方法以及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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18.发明授权Substituted 2,5-diamidoindoles as ECE inhibitors for the treatment of cardiovascular diseases 失效取代的2,5-二氨基吲哚作为治疗心血管疾病的ECE抑制剂公开(公告)号：US07045544B2
公开(公告)日：2006-05-16
申请号：US10490821
申请日：2002-09-16
申请人： Jens-Kerim Ergüden , Thomas Krahn , Christian Schröder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
发明人： Jens-Kerim Ergüden , Thomas Krahn , Christian Schröder , Johannes-Peter Stasch , Stefan Weigand , Hanno Wild , Michael Brands
IPC分类号： A61K31/404 , A61K31/4439 , A61K31/433 , C07D209/40 , C07D405/12
CPC分类号： C07D401/12 , C07D209/42
摘要： The invention relates to compounds of formula (I), to a method for the production thereof, and to the use of the same as pharmaceuticals for the treatment of diseases in humans and/or animals
摘要翻译： 本发明涉及式（I）化合物，其制备方法及其用作药物治疗人和/或动物疾病的方法
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