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    Stent Coating Nozzle Assembly
    11.
    发明申请
    Stent Coating Nozzle Assembly 有权
    支架喷涂组件

    公开(公告)号：US20080121175A1

    公开(公告)日：2008-05-29

    申请号：US12027077

    申请日：2008-02-06

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： B05C11/00

    CPC分类号： B05B7/061 ,  A61F2/82 ,  B05B13/0228 ,  B05D1/02 ,  B05D1/34

    摘要： A system, nozzle assembly, and method for coating a stent with a solvent and polymer are provided. The polymer can include a therapeutic substance or a drug. The polymer and solvent can be discharged from separate tubes disposed within another tube carrying moving air. The polymer and the solvent mix together when they are discharged and are atomized by the air. The ends of the tubes can be concentric with each other. The ends of the tubes can also be positioned relative to each other to prevent accumulation of polymer at the ends of the tubes.

    摘要翻译： 提供了一种用溶剂和聚合物涂覆支架的系统，喷嘴组件和方法。 聚合物可以包括治疗物质或药物。 聚合物和溶剂可以从设置在携带移动空气的另一个管中的单独的管排出。 当聚合物和溶剂排出并被空气雾化时，聚合物和溶剂混合在一起。 管的端部可以彼此同心。 管的端部也可以相对于彼此定位，以防止聚合物在管的端部积聚。

    Drug-eluting stent and delivery system with tapered stent in shoulder region
    13.
    发明授权
    Drug-eluting stent and delivery system with tapered stent in shoulder region 有权
    药物洗脱支架和带锥形支架的递送系统在肩部区域

    公开(公告)号：US07156869B1

    公开(公告)日：2007-01-02

    申请号：US10353219

    申请日：2003-01-27

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2250/0067 ,  Y10T29/49826

    摘要： A drug-eluting stent delivery system for the treatment of edge restenosis in a blood vessel. The drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent contacts a wall of the blood vessel to maintain the patency of the vessel. The drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent. A method for making the same is also disclosed herein.

    摘要翻译： 用于治疗血管中边缘再狭窄的药物洗脱支架递送系统。 药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个 锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。 药物洗脱支架接触血管的壁以维持血管的通畅。 药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分 气囊的第二端由锥形药物洗脱支架覆盖。 本文还公开了制备该方法的方法。

    Stent coating nozzle assembly
    16.
    发明授权
    Stent coating nozzle assembly 有权
    支架喷涂组件

    公开(公告)号：US08282024B2

    公开(公告)日：2012-10-09

    申请号：US12027077

    申请日：2008-02-06

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： B05B7/06

    CPC分类号： B05B7/061 ,  A61F2/82 ,  B05B13/0228 ,  B05D1/02 ,  B05D1/34

    摘要： A system, nozzle assembly, and method for coating a stent with a solvent and polymer are provided. The polymer can include a therapeutic substance or a drug. The polymer and solvent can be discharged from separate tubes disposed within another tube carrying moving air. The polymer and the solvent mix together when they are discharged and are atomized by the air. The ends of the tubes can be concentric with each other. The ends of the tubes can also be positioned relative to each other to prevent accumulation of polymer at the ends of the tubes.

    摘要翻译： 提供了一种用溶剂和聚合物涂覆支架的系统，喷嘴组件和方法。 聚合物可以包括治疗物质或药物。 聚合物和溶剂可以从设置在携带移动空气的另一个管中的单独的管排出。 当聚合物和溶剂排出并被空气雾化时，聚合物和溶剂混合在一起。 管的端部可以彼此同心。 管的端部也可以相对于彼此定位，以防止聚合物在管的端部积聚。

    DRUG-ELUTING STENT AND DELIVERY SYSTEM WITH TAPERED STENT IN SHOULDER REGION
    17.
    发明申请
    DRUG-ELUTING STENT AND DELIVERY SYSTEM WITH TAPERED STENT IN SHOULDER REGION 有权
    药物治疗手段和交付系统与肩膀区域的棘手

    公开(公告)号：US20120060969A1

    公开(公告)日：2012-03-15

    申请号：US13285627

    申请日：2011-10-31

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： B65B1/04

    CPC分类号： A61L31/16 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2/958 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2230/0013 ,  A61F2250/0067 ,  Y10T29/49826

    摘要： A drug-eluting stent delivery system has a balloon disposed about at least a portion of a catheter, the balloon having a first end and a second end and a working length therebetween, the first end and the second end each including a tapered portion, each tapered portion being attached to the catheter, the balloon being inflatable from a collapsed configuration to an inflated configuration. A drug-eluting stent has a first end and a second end, the first end and the second end each including a tapered portion, wherein the drug-eluting stent is disposed over the balloon such that at least a portion of the first end and the second end of the balloon are covered by the tapered drug-eluting stent.

    摘要翻译： 药物洗脱支架递送系统具有围绕导管的至少一部分设置的球囊，所述球囊具有第一端和第二端以及其间的工作长度，第一端和第二端各自包括锥形部分，每个包括锥形部分 锥形部分附接到导管，气囊可从折叠构型充气到膨胀构型。 药物洗脱支架具有第一端和第二端，第一端和第二端各自包括锥形部分，其中药物洗脱支架设置在气囊上方，使得第一端和第二端的至少一部分 气囊的第二端由锥形药物洗脱支架覆盖。

    Coatings for drug delivery devices
    18.
    发明授权
    Coatings for drug delivery devices 有权
    药物输送装置用涂料

    公开(公告)号：US08124119B2

    公开(公告)日：2012-02-28

    申请号：US12511919

    申请日：2009-07-29

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： A61F13/00 ,  A61F2/00

    CPC分类号： A61L31/10 ,  A61L27/16 ,  A61L27/30 ,  A61L27/54 ,  A61L31/16 ,  C09D129/04 ,  C09D129/06 ,  C08L29/02

    摘要： A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.

    摘要翻译： 一种基于聚烯烃衍生物的医疗器械聚合物涂层。 描述了各种聚合物以制备用于医疗装置的涂层，特别是用于药物递送支架。 聚合物包括具有至少一种烯烃衍生单元和至少一种衍生自乙烯醇，烯丙醇及其衍生物的单元的均聚物，共聚物和三元共聚物。

    Method of producing stent-balloon assembly
    20.
    发明授权
    Method of producing stent-balloon assembly 有权
    生产支架 - 球囊组件的方法

    公开(公告)号：US08011078B2

    公开(公告)日：2011-09-06

    申请号：US12692537

    申请日：2010-01-22

    申请人： Stephen Dirk Pacetti

    发明人： Stephen Dirk Pacetti

    IPC分类号： B23P11/00 ,  B23P25/00 ,  A61F2/82

    CPC分类号： A61F2/958 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2002/9522 ,  A61F2240/001 ,  A61L31/022 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/06 ,  B05C11/00 ,  B21D39/048 ,  Y10T29/49863 ,  Y10T29/49865 ,  Y10T29/49925 ,  Y10T29/49927 ,  Y10T29/53996

    摘要： A method of producing a stent-balloon assembly is disclosed which includes providing a stent having a polymeric component; exposing the stent to a relative humidity of 20% to 100%; and crimping the stent on a balloon of a catheter assembly. The polymeric component could be at least part of the material from which the stent is made or could be a constituent of a coating for the stent, such as a drug delivery coating. In lieu of or in addition to the application of humidity, a plasticizing agent can be applied to the polymeric component. A crimping device is also disclosed which allows the stent to be exposed to humidity during the crimping process.

    摘要翻译： 公开了一种制造支架 - 球囊组件的方法，其包括提供具有聚合物组分的支架; 将支架暴露于20％至100％的相对湿度; 并将支架卷曲在导管组件的气球上。 聚合物组分可以是制造支架的材料的至少一部分，或者可以是用于支架的涂层的成分，例如药物递送涂层。 除了施加湿度之外，还可以将增塑剂施加到聚合物组分上。 还公开了压接装置，其允许支架在压接过程期间暴露于湿度。