-
11.发明申请公开(公告)号：US20100008929A1
公开(公告)日：2010-01-14
申请号：US12464057
申请日：2009-05-11
申请人： Jan G. J. van de Winkel , Marcus A. van Dijk , Edward Halk , Arnout F. Gerritsen , Jorgen Petersen , Ole Baadsgaard
发明人： Jan G. J. van de Winkel , Marcus A. van Dijk , Edward Halk , Arnout F. Gerritsen , Jorgen Petersen , Ole Baadsgaard
CPC分类号： C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56966
摘要： Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与人EGFR特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US20080166347A1
公开(公告)日：2008-07-10
申请号：US11827306
申请日：2007-07-11
申请人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
发明人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
IPC分类号： A61K39/00
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
摘要翻译： 公开了与IL-15（例如人IL-15）特异性结合的分离的人单克隆抗体以及相关的基于抗体的组合物和分子。 人抗体可以通过经历V-D-J重组和同种型转换而在能够产生人单克隆抗体多重同种型的转染瘤或非人转基因动物例如转基因小鼠中产生。 还公开了包含人抗体，非人转基因动物和产生人抗体的杂交瘤的药物组合物，以及使用人抗体的治疗和诊断方法。
-
公开(公告)号：US20080166802A1
公开(公告)日：2008-07-10
申请号：US11827195
申请日：2007-07-11
申请人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
发明人： Jan G.J. van de Winkel , Marcus A. van Dijk , Janine Schuurman , Arnout F. Gerritsen , Ole Baadsgaard , Jorgen Petersen
CPC分类号： C07K16/24 , A01K2217/05 , A61K2039/505 , C07K16/244 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , Y10S514/885
摘要： Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
-
公开(公告)号：US20130171148A1
公开(公告)日：2013-07-04
申请号：US13700246
申请日：2011-05-27
申请人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
发明人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了与人表皮生长因子受体2（HER2）结合的分离的单克隆抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
-
公开(公告)号：US08586041B2
公开(公告)日：2013-11-19
申请号：US12464057
申请日：2009-05-11
申请人： Jan G. J. van de Winkel , Marcus Antonius van Dijk , Edward Halk , Arnout F. Gerritsen , Jorgen Petersen , Ole Baadsgaard
发明人： Jan G. J. van de Winkel , Marcus Antonius van Dijk , Edward Halk , Arnout F. Gerritsen , Jorgen Petersen , Ole Baadsgaard
IPC分类号： A61K39/395 , C12P21/08 , C07K16/28
CPC分类号： C07K16/2863 , A01K2217/05 , A01K2217/075 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56966
摘要： Isolated human monoclonal antibodies which specifically bind to human EGFR, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
-
公开(公告)号：US09714294B2
公开(公告)日：2017-07-25
申请号：US13700246
申请日：2011-05-27
申请人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
发明人： Bart De Goeij , Edward Norbert Van Den Brink , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , David Satijn , Jan Van De Winkel , Paul Parren
IPC分类号： C07K16/30 , A61K39/395 , C07K16/32 , A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/32 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , Y02A50/472
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
-
公开(公告)号：US09040050B2
公开(公告)日：2015-05-26
申请号：US12442808
申请日：2007-09-26
申请人： Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人： Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号： A61K39/395 , C07K16/28 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要： The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.
摘要翻译： 本发明涉及使用包含结合CD38的抗体，皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
-
公开(公告)号：US20100092489A1
公开(公告)日：2010-04-15
申请号：US12442808
申请日：2007-09-26
申请人： Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
发明人： Jan Van De Winkel , Paul Parren , Yvo Graus , Judith Oprins , Michel De Weers , Martine Van Vugt , Ole Baadsgaard , Steen Lisby
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/2896 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/34 , A61K2300/00
摘要： The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non- corticosteroid chemotherapeutic agent.
摘要翻译： 本发明涉及使用包含结合CD38的抗体，皮质类固醇和非皮质类固醇化学治疗剂的组合疗法治疗癌症的新方法。
-
公开(公告)号：US09150658B2
公开(公告)日：2015-10-06
申请号：US13133811
申请日：2009-12-09
申请人： Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
发明人： Sandra Verploegen , David P. E. Satijn , Rene Hoet , Paul Parren , Jan Van De Winkel , Vibeke Miller Breinholt , Eva Ehrnrooth , Ole Baadsgaard , Tom Vink , Willem Karel Bleeker , Mischa Houtkamp , Maroeska Oudshoorn , Rob N. De Jong
IPC分类号： C07K16/36 , A61K39/395
CPC分类号： C07K16/36 , A61K39/395 , A61K2039/505 , C07K2317/21 , C07K2317/31 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了结合人TF和相关的基于抗体的组合物和分子的分离的人单克隆抗体。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
-
公开(公告)号：US20130189271A1
公开(公告)日：2013-07-25
申请号：US13700341
申请日：2011-05-27
申请人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
发明人： Bart De Goeij , Simone De Haij , Thilo Riedl , Rene Hoet , Ole Baadsgaard , Jan Van De Winkel , David Satijn , Paul Parren , Aran Frank Labrijn , Joyce I. Meesters , Janine Schuurman , Edward Norbert Van Den Brink
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related anti-body-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
摘要翻译： 公开了与人表皮生长因子受体2（HER2）结合的分离的单克隆抗体以及相关的抗体基组合物和分子。 还公开了包含抗体的药物组合物和使用抗体的治疗和诊断方法。
-
-
-
-
-
-
-
-
-
搜索结果
35 条记录 (耗时 0.036 秒)
