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11.发明授权Apparatus for applying a tissue adhesive on the basis of human or animal proteins 失效用于在人或动物蛋白质的基础上施用组织粘合剂的装置
公开(公告)号：US4359049A
公开(公告)日：1982-11-16
申请号：US246431
申请日：1981-03-23
申请人： Heinz Redl , Gert Kriwetz
发明人： Heinz Redl , Gert Kriwetz
CPC分类号： A61B17/00491 , A61M5/19 , A61B2017/00495
摘要： An arrangement for applying a tissue adhesive on the basis of human or animal proteins for seamlessly or seam-supportingly connecting human or animal tissue or organ parts, sealing wounds, stopping bleedings and the like, which tissue adhesive is formed in situ by bringing together solutions of the proteins and of clot-promoting coagulation factors, includes a holding device for a plurality of syringe bodies ending in coni. In order to achieve a reliable mixing of the tissue adhesive components by single-hand operation with a premature hardening of the components prior to reaching the laceration site being prevented, the coni of the individual syringe bodies are connected by a collecting head having separated conveying channels for the components of the tissue adhesive emerging from the coni. A common actuating device is provided for the plungers of all syringe bodies.
摘要翻译： 用于基于人或动物蛋白质施用组织粘合剂的装置，用于无缝或缝合支撑地连接人或动物组织或器官部分，密封伤口，停止出血等，该组织粘合剂通过将溶液聚集在一起而形成 的蛋白质和促凝血凝血因子，包括用于以锥体终止的多个注射器体的保持装置。 为了通过单手操作实现组织粘合剂组分的可靠混合，在到达撕裂部位之前组件的过早硬化被阻止，各注射器主体的锥体通过具有分离的输送通道的收集头连接 用于从锥体出现的组织粘合剂的组分。 为所有注射器主体的柱塞提供常见的致动装置。
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公开(公告)号：US09179898B2
公开(公告)日：2015-11-10
申请号：US12650185
申请日：2009-12-30
申请人： Heinz Redl , Zafar Khakpour , Rene Fortelny
发明人： Heinz Redl , Zafar Khakpour , Rene Fortelny
CPC分类号： A61B17/00491 , A61B17/3474 , A61B2017/00495 , A61B2017/00522
摘要： A laparoscopic tissue sealant spray apparatus and system having a laparoscopic tissue sealant spray assembly combined with a trocar assembly, the tissue sealant spray assembly having an elongate delivery tube. A spray outlet at a distal end of the elongate delivery tube may be rounded or angled. A ring member provided at the distal end of the elongate delivery tube directs a spray cone toward a portion of a target tissue site, and the spray cone may be repositioned to a different portion of the target tissue site by rotation of the elongate delivery tube. The trocar assembly includes a vent opening that connects to a venting valve member that provides a vent path which passively opens upon operation of the tissue sealant spray assembly, avoiding excessive pressure build-up within a body cavity.
摘要翻译： 一种腹腔镜组织密封剂喷雾装置和系统，其具有与套管针组件结合的腹腔镜组织密封剂喷涂组件，所述组织密封剂喷涂组件具有细长的输送管。 在细长输送管的远端处的喷雾出口可以是圆形的或成角度的。 设置在细长输送管的远端处的环形构件将喷雾锥体朝向目标组织部位的一部分引导，并且可以通过细长输送管的旋转将喷雾锥体重新定位到目标组织部位的不同部分。 套管针组件包括连接到通气阀构件的通气口，该通气孔构件提供在组织密封剂喷涂组件的操作时被动打开的通气路径，从而避免体腔内过度的压力积聚。
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公开(公告)号：US08469289B2
公开(公告)日：2013-06-25
申请号：US13053201
申请日：2011-03-21
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： A tissue sealant applicator system includes a tissue sealant applicator having an elongate body forming a bore containing a tissue sealant component, a piston, and a spray adaptor in fluid communication with the bore and forming a gas flow path. The system also includes a control unit adapted to be connected to a gas source, and a first gas passageway connecting the gas flow path and the control unit. The applicator includes an actuating member cooperatively associated with the piston to eject the tissue sealant from the bore upon user actuation. The control unit is adapted to supply gas from the gas source to the first gas passageway essentially simultaneously with user actuation of the actuating member, and to permit the supply of gas to the spray adaptor from the gas source to continue to flow for a predetermined time delay after the user stops actuating the actuating member.
摘要翻译： 组织密封剂施加器系统包括组织密封剂施加器，其具有细长主体，所述细长主体形成包含与所述孔流体连通并形成气体流路的组织密封剂组件，活塞和喷雾适配器的孔。 该系统还包括适于连接到气源的控制单元和连接气体流路和控制单元的第一气体通路。 施加器包括与活塞协作地关联的致动构件，以在用户致动时将组织密封剂从孔中排出。 控制单元适于在用户致动致动构件的同时基本同时将来自气体源的气体供应到第一气体通道，并且允许从气体源向喷雾适配器供应气体以继续流动预定时间 在用户停止致动致动构件之后延迟。
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公开(公告)号：US20100292717A1
公开(公告)日：2010-11-18
申请号：US12467616
申请日：2009-05-18
IPC分类号： A61B17/03
CPC分类号： A61B50/00 , A61B19/02 , A61B2019/4884 , A61B2050/002 , A61B2090/0816 , A61F2/0063 , A61F2/0077 , A61F2002/009 , A61L31/041
摘要： The present invention provides a method of fixating a mesh implant to a tissue of a subject comprising attaching said mesh implant to said tissue, covering said mesh implant by an antiadhesive barrier, wherein said antiadhesive barrier is attached to said mesh implant by a biocompatible adhesive.
摘要翻译： 本发明提供了一种将网状植入物固定到受试者的组织的方法，包括将所述网状植入物附着到所述组织，通过防粘附屏障覆盖所述网状植入物，其中所述防粘附屏障通过生物相容性粘合剂附着到所述网状植入物上。
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公开(公告)号：US20100203050A1
公开(公告)日：2010-08-12
申请号：US12449639
申请日：2008-02-20
申请人： Robert Weik , Thomas Hemetsberger , Heinz Redl
发明人： Robert Weik , Thomas Hemetsberger , Heinz Redl
IPC分类号： A61K39/395 , C12P21/08 , C12P21/06
CPC分类号： C07K14/505 , A61K38/1816 , C07K2319/30
摘要： The present invention relates to recombinant fusion proteins wherein erythropoietin (EPO) is linked via its C-terminus to an Fc fragment, and wherein said recombinant fusion proteins are further carbamoylated at the primary amines of the fusion protein. More specifically the invention relates to carbamoylated EPO-Fc fusion proteins, wherein at least one, preferably two or more, lysine amine residues and/or the N-terminal amino acid of said fusion protein are carbamoylated. The carbamoylated EPO-Fc fusion proteins of the present invention having a reduced hematopoietic activity whereas the tissue regenerative activity, i.e. the nerval cell regenerative activity remains unaltered or is even enhanced as compared to unmodified EPO-Fc fusion proteins. The invention further relates to a process for the manufacture of such fusion proteins and to pharmaceutical compositions containing them, as well as to the use of such fusion proteins and pharmaceutical compositions for medical therapy.
摘要翻译： 本发明涉及其中促红细胞生成素（EPO）通过其C-末端连接到Fc片段的重组融合蛋白，并且其中所述重组融合蛋白在融合蛋白的伯胺进一步氨基甲酰化。 更具体地，本发明涉及氨基甲酰化EPO-Fc融合蛋白，其中所述融合蛋白的至少一个，优选两个或更多个赖氨酸残基和/或N-末端氨基酸被氨基甲酰化。 与未修饰的EPO-Fc融合蛋白相比，具有降低的造血活性的本发明的氨基甲酰化EPO-Fc融合蛋白，而组织再生活性即神经细胞再生活性保持不变或甚至增强。 本发明还涉及制备这种融合蛋白的方法和含有它们的药物组合物的方法，以及这种融合蛋白和药物组合物在医学治疗中的用途。
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公开(公告)号：US07537174B2
公开(公告)日：2009-05-26
申请号：US11331243
申请日：2006-01-12
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： The present invention is generally directed to various structures for applying a sealant to a work surface. In one aspect of the invention, a sealant applicator assembly is provided for use with an apparatus of the type having an elongated body defining an interior bore and having a piston movably positioned in the bore and a pusher member operatively associated with the piston. The assembly comprises a spray adaptor adapted to communicate with the bore of the body and defining a distal outlet. A first gas passageway is cooperatively associated with the distal outlet and configured to direct gas to create a spray discharge of the sealant. An actuating member is adapted to be cooperative associated with a pusher member to eject sealant through the distal outlet and is operative to simultaneously actuate a supply of gas to the first gas passageway for creating a spray discharge of sealant.
摘要翻译： 本发明一般涉及用于向工作表面施加密封剂的各种结构。 在本发明的一个方面，提供密封剂施加器组件，用于具有限定内孔的细长主体并具有可移动地定位在孔中的活塞的类型的装置，以及与活塞可操作地相关联的推动构件。 组件包括适于与主体的孔连通并限定远侧出口的喷雾适配器。 第一气体通道与远端出口协作地相关联并且构造成引导气体以产生密封剂的喷射排出。 致动构件适于与推动器构件协作关联以通过远端出口喷射密封剂，并且可操作以同时致动向第一气体通道供应气体，以产生密封剂的喷射排放。
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公开(公告)号：US20060177812A1
公开(公告)日：2006-08-10
申请号：US10533255
申请日：2003-10-30
申请人： Guntram Schnetz , Heinz Redl , Kurt Zatloukal
发明人： Guntram Schnetz , Heinz Redl , Kurt Zatloukal
摘要： The invention relates to a method and a device for manipulating samples, in particular tissue samples, comprising at least one needle (2) for punching holes (34) in sample carriers (4) and at least one further needle (3) for punching samples out of preparations (5), wherein a device for detecting the position of the surface of the sample carriers (4) is provided. According to the invention, the device for detecting the position of the surface of the sample carriers (4) or preparations (5) is formed by suction lines (9) opening into the needles (2, 3), whereby the suction lines (9) are connected with a unit (11) for detecting negative pressure so that the approach of the needles (2, 3) to the surface of the sample carriers (4) or the preparations (5) is detectable by the resulting negative pressure and that a drive unit (7) is provided for displacing the needles (2, 3) relative to the sample carrier (4) or preparation (5) from the detected position of the surface to a predefined punching depth (D).
摘要翻译： 本发明涉及用于操纵样品，特别是组织样本的方法和装置，其包括至少一个针（2），用于在样品载体（4）中冲孔（34）和至少一个另外的针（3），用于冲压样品 （5），其中提供了用于检测样品载体（4）的表面的位置的装置。 根据本发明，用于检测样品载体（4）或制剂（5）的表面的位置的装置由通向针（2,3）的吸入管线（9）形成，由此吸入管线（9） ）与用于检测负压的单元（11）连接，使得针（2,3）到样品载体（4）或制剂（5）的表面的接近可由所得到的负压检测到， 提供驱动单元（7），用于使针（2,3）相对于样品载体（4）或准备物（5）从表面的检测位置移动到预定的冲孔深度（D）。
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公开(公告)号：US06713453B2
公开(公告)日：2004-03-30
申请号：US09963156
申请日：2001-09-25
申请人： Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
发明人： Heinz Redl , Walter Fuerst , Rudolf Kneidinger , Sam L. Helgerson , Douglas Looker , Elisabeth M. Inman , Jane P. Richards , Catalina Wong
IPC分类号： A61K3818
CPC分类号： C07K14/745 , A61K38/00 , A61K47/64 , A61K47/6435 , A61K47/665 , B82Y5/00
摘要： A fibrin/fibrinogen binding conjugate for forming a depot for the sustained release of a pharmaceutically active substance from a fibrin clot. The conjugate comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF165 C-terminal domain fused to a wound-healing substance such as leptin.
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公开(公告)号：US4631055A
公开(公告)日：1986-12-23
申请号：US705725
申请日：1985-02-26
申请人： Heinz Redl , Georg Habison
发明人： Heinz Redl , Georg Habison
IPC分类号： A61L24/00 , A61B17/00 , A61B17/04 , A61L26/00 , A61M3/00 , A61M5/178 , A61M35/00 , B05B7/04 , A61M5/00
CPC分类号： A61B17/00491 , A61M3/005 , A61B2017/00495
摘要： There is disclosed an arrangement for applying a tissue adhesive based on human or animal proteins to seamlessly or seam-supportingly connect human or animal tissue or organ parts, to seal wounds, stop bleedings and the like. The tissue adhesive is formed in situ by combining solutions of the proteins and of blood-clot-promoting coagulation factors. The arrangement includes a plurality of containers ending in joining pieces for accommodating the components to be applied. A connecting head is attachable to the joining pieces of the containers, which includes a separate conveying channel for each of the components to be applied. In order to design an arrangement of the above defined kind to be troublefree and to render it usable even for hardly accessible application sites, without requiring an exchange of parts of the arrangement at an interruption of the component flow, and to be able to use it with and without the help of an endoscope, the connecting head includes an additional conveying channel for a medicinal gas. This channel leads to the front side of the connecting head parallel and closely adjacent the remaining conveying channels. The connecting head is continued in either a multi-lumen catheter containing a gas-conveying channel or in a mixing needle.
摘要翻译： 公开了一种用于施用基于人或动物蛋白质的组织粘合剂以无缝或缝合支撑地连接人或动物组织或器官部分，以密封伤口，停止出血等的布置。 组合粘合剂通过组合蛋白质溶液和促凝血凝血因子在原位形成。 该装置包括多个容器，其以接合件结束，以容纳要施加的部件。 连接头可附接到容器的连接件，其包括用于要施加的每个部件的单独输送通道。 为了设计上述定义类型的布置是无故障的，并且即使对于难以访问的应用场所也可使其可用，而不需要在部件流程中断时更换部件，并且能够使用它 在没有内窥镜的帮助下，连接头包括用于医用气体的附加输送通道。 该通道通向连接头的前侧平行并紧邻其余输送通道。 连接头在包含气体输送通道的多腔导管中或在混合针中连续。
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公开(公告)号：US07909267B2
公开(公告)日：2011-03-22
申请号：US12390014
申请日：2009-02-20
CPC分类号： B05B7/0408 , A61B17/00491 , A61B2017/00495 , B05B7/0483 , B05C17/00516 , B05C17/00553 , B05C17/015
摘要： An applicator includes a bore for containing a sealant component, a piston moveably positioned in the bore, a plunger member connected to the piston with a distal end disposed within the bore and a proximal end depending from the bore, a distal outlet communicating with the bore and connectable to a gas source, and an actuating member carried by the proximal end of the plunger member to move with the plunger member as the plunger member moves along the bore. The applicator may be used in a system with a gas source connected to the distal outlet, and a control unit connected to the actuating member and the gas source, the control unit adapted to supply gas to the distal outlet from the gas source essentially simultaneous with a force applied to the actuating member.
摘要翻译： 施加器包括用于容纳密封剂部件的孔，可移动地定位在所述孔中的活塞，连接到所述活塞的柱塞构件，其远端设置在所述孔内以及从所述孔悬垂的近端，远端与所述孔连通 并且可连接到气体源，以及由柱塞构件的近端承载的致动构件，随着柱塞构件沿着孔移动，与柱塞构件一起移动。 施用器可以用在具有连接到远端出口的气源的系统中，以及连接到致动构件和气源的控制单元，所述控制单元适于从气源向远端出口提供气体，基本上与 施加到致动构件的力。
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