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    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
    12.
    发明授权
    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
    通过可插入热交换导管来控制患者体温的方法和系统

    公开(公告)号：US07879077B2

    公开(公告)日：2011-02-01

    申请号：US11674119

    申请日：2007-02-12

    申请人： Timothy R. MacHold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    发明人： Timothy R. MacHold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F7/00

    CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    摘要翻译： 包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。 控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。 加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。 提供了一种用于使体温上升或下降而没有过冲的温度控制方案。 一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。 可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元 。

    Endoscopic microsurgical instruments and methods
    16.
    发明授权
    Endoscopic microsurgical instruments and methods 失效
    内窥镜显微外科手术和方法

    公开(公告)号：US5618306A

    公开(公告)日：1997-04-08

    申请号：US560441

    申请日：1995-11-17

    申请人： Alex T. Roth ,  Scott H. Miller

    发明人： Alex T. Roth ,  Scott H. Miller

    IPC分类号： A61B17/00 ,  A61B17/04 ,  A61B17/12 ,  A61B17/128 ,  A61B17/28

    CPC分类号： A61B17/2909 ,  A61B17/1285 ,  A61B17/0469 ,  A61B2017/00243 ,  A61B2017/2845 ,  A61B2017/2912 ,  A61B2017/2919 ,  A61B2017/2926 ,  A61B2017/2946 ,  A61B2017/305

    摘要： The invention provides devices and method for performing extremely small-scale, minimally-invasive microsurgery such as thoracoscopic coronary artery bypass grafting. The instruments of the invention utilize a symmetrical, forcep-like actuator which provides extremely precise actuator and control of the instrument and which mimics the feel of instruments used in conventional open surgical procedures. The instruments generally include a pair of coaxially arranged shafts, an end-effector at the distal ends of the shafts, and an actuator at the proximal ends of the shafts. The actuator includes a pair of arms pivotally coupled to one of either the outer or inner shalt, and a pair of links pivotally coupled at one end to the arms, and at a second end to the other of the shafts. The links are coupled to a proximal portion of the arms to maximize mechanical advantage and reduce interference. The actuator may be easily adapted for either pull-type or push-type actuation, and for either outer shaft or inner shaft translation. The end-effectors may have a variety of configurations, including needle drivers, forceps, scissors, and clip appliers.

    摘要翻译： 本发明提供了用于进行极小规模，微创显微外科手术如胸腔镜冠状动脉旁路移植术的装置和方法。 本发明的仪器使用对称的强力致动器，其提供极其精确的致动器和仪器的控制，并模拟常规开放式外科手术中使用的仪器的感觉。 仪器通常包括一对同轴布置的轴，在轴的远端处的末端执行器和在轴的近端处的致动器。 致动器包括一对臂，其可枢转地联接到外部或内部之一中的一个，以及在一端枢转地联接到臂的一对连杆，并且在另一端处连接到另一个轴。 连杆联接到臂的近端部分以最大化机械优点并减少干扰。 致动器可以容易地适用于拉式或推式致动，以及用于外轴或内轴平移。 末端执行器可以具有各种配置，包括针驱动器，镊子，剪刀和夹具装置。

    Gel electrophoresis system
    17.
    发明授权
    Gel electrophoresis system 失效
    凝胶电泳系统

    公开(公告)号：US5410412A

    公开(公告)日：1995-04-25

    申请号：US178035

    申请日：1994-01-06

    申请人： Erich A. Gombocz ,  Robert R. Clappier ,  Wilhelm Kerth ,  David H. Rammler ,  Alex T. Roth

    发明人： Erich A. Gombocz ,  Robert R. Clappier ,  Wilhelm Kerth ,  David H. Rammler ,  Alex T. Roth

    IPC分类号： G01N27/447 ,  G01N21/25

    CPC分类号： G01N27/44721 ,  G01N27/44704 ,  G01N27/44782

    摘要： An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring is provided so as to monitor the progress of the electrophoretic separation and vary conditions to change the progress as desired. A computer is employed which receives the signals from the electrophoretic and photometric apparatuses and regulates temperature and voltage to either maintain conditions, or change the conditions to vary the progress of the electrophoresis. Gel molds are provided for forming the lanes in a gel plate, as well as a light module, for reading the bands present in the gel lanes with the photometer.

    摘要翻译： 提供了一种电泳系统，其允许进行电泳，同时监测和调节凝胶中的温度和电场梯度。 此外，提供光度监测以监测电泳分离的进展并改变条件以根据需要改变进展。 使用计算机，其接收来自电泳和光度测量装置的信号并调节温度和电压以维持条件，或改变条件以改变电泳进程。 提供凝胶模具用于在凝胶板中形成通道以及光模块，用于通过光度计读取凝胶通道中存在的条带。

    Gel electrophoresis system including optical stage, sample applicator and sample retriever
    18.
    发明授权
    Gel electrophoresis system including optical stage, sample applicator and sample retriever 失效
    凝胶电泳系统，包括光学平台，样品涂布器和样品回收器

    公开(公告)号：US5275710A

    公开(公告)日：1994-01-04

    申请号：US837067

    申请日：1992-02-14

    申请人： Erich A. Gombocz ,  Alex T. Roth

    发明人： Erich A. Gombocz ,  Alex T. Roth

    IPC分类号： G01N27/447 ,  G01N27/26 ,  B01D57/02

    CPC分类号： G01N27/44704 ,  G01N27/44721 ,  G01N27/44782

    摘要： An electrophoretic system is provided which allows for carrying out electrophoresis while monitoring and regulating the temperature and the electrical field gradient in the gel. In addition, photometric monitoring, including use of an optical stage, is provided so as to monitor the progress of the electrophoretic separation and vary conditions to change the progress as desired. A computer is employed which receives the signals from the electrophoretic and photometric apparatuses and regulates temperature and voltage to either maintain conditions, or change the conditions to vary the progress of the electrophoresis and to store the separation results. A sample applicator and a sample retriever are also provided, to provide even and consistent application of sample to the gel and to allow recovery of portions of the sample without destroying or removing pieces from the gel. Gel molds are provided for forming the lanes in a gel plate, as well as a light module, for reading the bands present in the gel lanes with the photometer.

    摘要翻译： 提供了一种电泳系统，其允许进行电泳，同时监测和调节凝胶中的温度和电场梯度。 此外，提供包括使用光学级的光度监测，以监视电泳分离的进展并改变条件以根据需要改变进展。 接收来自电泳和测光装置的信号并调节温度和电压以维持条件或改变条件以改变电泳进程并存储分离结果的计算机。 还提供样品施加器和样品回收器，以将样品均匀且一致地应用于凝胶并允许回收部分样品而不破坏或从凝胶中除去碎片。 提供凝胶模具用于在凝胶板中形成通道以及光模块，用于通过光度计读取凝胶通道中存在的条带。

    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
    19.
    发明授权
    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权

    公开(公告)号：US10085880B2

    公开(公告)日：2018-10-02

    申请号：US13164648

    申请日：2011-06-20

    申请人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    发明人： Timothy R. Machold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F7/00 ,  A61F7/12 ,  A61M25/10 ,  A61B17/00 ,  A61B17/22 ,  A61F7/10

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.