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    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
    1.
    发明授权
    Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter 有权
    通过可插入热交换导管来控制患者体温的方法和系统

    公开(公告)号：US07879077B2

    公开(公告)日：2011-02-01

    申请号：US11674119

    申请日：2007-02-12

    申请人： Timothy R. MacHold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    发明人： Timothy R. MacHold ,  Wade A. Keller ,  Alex T. Roth ,  Nicole Denise Bloom

    IPC分类号： A61F7/00

    CPC分类号： A61F7/0085 ,  A61B2017/00092 ,  A61B2017/00119 ,  A61B2017/00123 ,  A61B2017/00199 ,  A61B2017/22051 ,  A61F7/0097 ,  A61F7/10 ,  A61F7/123 ,  A61F2007/0054 ,  A61F2007/0096 ,  A61F2007/126 ,  A61M25/10 ,  A61M25/1011 ,  A61M2025/1072 ,  A61M2025/1086 ,  A61M2205/12 ,  A61M2205/127

    摘要： Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15″ cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.

    摘要翻译： 包括诱导低温的状态的患者的温度改变方法和装置，或其选定区域。 使用在其中流体热交换介质循环的内部热交换导管来实现温度改变。 几个公开的变型中的任何一个的热交换盒附接到导管的循环导管，热交换盒的尺寸适于接合各种所描述的可重复使用的控制单元之一内的空腔。 控制单元包括加热器/冷却器装置，用户输入装置和连接以接收来自身体和系统周围的各种传感器的输入的处理器。 加热器/冷却器装置可以是热电，以使得能够基于极性进行加热和15“冷却。 提供了一种用于使体温上升或下降而没有过冲的温度控制方案。 一次性热交换盒可以包括与可再使用的控制单元内的泵驱动机构接合的整体泵头。 可以提供多于一个控制单元以接收相同的热交换盒，使得例如最初可以使用大容量控制单元，并且一旦患者达到期望的目标温度，可以取代较小的电池供电的单元 。

    Heat exchange catheter with discrete heat exchange elements
    6.
    发明授权
    Heat exchange catheter with discrete heat exchange elements 有权
    带有离散热交换元件的换热导管

    公开(公告)号：US06264679B1

    公开(公告)日：2001-07-24

    申请号：US09378578

    申请日：1999-08-20

    申请人： Wade E. Keller ,  Timothy R. MacHold ,  Mark A. Saab

    发明人： Wade E. Keller ,  Timothy R. MacHold ,  Mark A. Saab

    IPC分类号： A61F700

    CPC分类号： A61F7/12 ,  A61F2007/126

    摘要： A catheter for exchanging heat with a body fluid is disclosed. The catheter includes a main shaft and a heat exchange region having a plurality of heat exchange elements each having a length and opposed ends. Each of the elements is attached on at least one of its ends to the shaft and disposed so that when inserted in a fluid body cavity having body fluid therein, the body fluid may circumferentially surround each heat exchange element along a portion of the length of the heat exchange element. The catheter includes a fluid circulation path therein, which desirably includes the hollow lumen within each of heat exchange elements. The heat exchange elements may be connected at two points along the shaft using manifolds that are in fluid communication with fluid flow paths within the shaft. Alternatively, the heat exchange elements may be connected at only one point and be permitted to float in a proximal or distal direction with respect to the catheter. The heat exchange region may be formed on a distal portion of the catheter, or may be formed along the entire length thereof. In the former configuration, an insulating member, such as a balloon, may be provided along the shaft proximal to the heat exchange region. Ribs may be provided on each heat exchange element to disrupt flow therearound and increase heat exchange. Each of the heat exchange elements may be non-circular in cross-section, and may extend in an undulating path with respect to the catheter shaft.

    摘要翻译： 公开了一种用于与体液交换热量的导管。 导管包括主轴和具有多个热交换元件的热交换区域，每个热交换元件具有长度和相对端。 每个元件的至少一个端部连接到轴上并且被设置为使得当插入其中具有体液的流体体腔中时，体液可以沿着长度方向的一部分周向地围绕每个热交换元件 热交换元件 导管包括其中的流体循环路径，其理想地包括在每个热交换元件内的中空腔。 热交换元件可以使用与轴内的流体流动路径流体连通的歧管在轴的两个点处连接。 或者，热交换元件可以仅在一个点处连接并且允许相对于导管在近端或远端方向上浮动。 热交换区域可以形成在导管的远端部分上，或者可以沿其整个长度形成。 在前一种构造中，可以沿着靠近热交换区域的轴设置绝缘构件，例如气球。 可以在每个热交换元件上提供肋以破坏其周围的流动并增加热交换。 每个热交换元件的横截面可以是非圆形的，并且可以相对于导管轴在起伏的路径中延伸。