-
11.发明授权公开(公告)号：US08841077B2
公开(公告)日：2014-09-23
申请号：US11711518
申请日：2007-02-27
申请人： Lisa A. Paige , Matthew W. Mitchell , Anne Evans , Don Harvan , Kay A. Lawton , Robert Brown , Merit Cudkowicz
发明人： Lisa A. Paige , Matthew W. Mitchell , Anne Evans , Don Harvan , Kay A. Lawton , Robert Brown , Merit Cudkowicz
CPC分类号： G01N33/6896 , G01N2500/10 , G01N2800/28 , G01N2800/2835 , G01N2800/56 , Y10T436/24
摘要： The present invention provides various biomarkers of amyotrophic lateral sclerosis (ALS). The present invention also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of determining predisposition to ALS, methods of monitoring progression/regression of ALS, methods of assessing efficacy of compositions for treating ALS, methods of screening compositions for activity in modulating biomarkers of ALS, methods of treating ALS, as well as other methods based on biomarkers of ALS.
摘要翻译： 本发明提供各种肌萎缩性侧索硬化症（ALS）的生物标志物。 本发明还提供了使用生物标志物的各种方法，包括ALS诊断方法，ALS倾向性测定方法，ALS进展/回归监测方法，评估组合物治疗ALS功效的方法，筛选组合物的方法 调节ALS生物标志物的活性，治疗ALS的方法，以及基于ALS生物标志物的其他方法。
-
12.发明授权公开(公告)号：US08546098B2
公开(公告)日：2013-10-01
申请号：US13457620
申请日：2012-04-27
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： C12Q1/54
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance. These biomarkers may be used to monitor the progression or regression of insulin resistance or to monitor the efficacy of insulin resistance treatment. Also provided are suites of small molecule entities as biomarkers for insulin resistance.
摘要翻译： 提供了与胰岛素抵抗相关的生物标志物，以及使用这些生物标志物作为胰岛素抵抗的生物标志物的方法。 这些生物标志物可用于监测胰岛素抵抗的进展或消退或监测胰岛素抵抗治疗的功效。 还提供了小分子实体的套件作为胰岛素抵抗的生物标志物。
-
公开(公告)号：US20090075284A1
公开(公告)日：2009-03-19
申请号：US12192539
申请日：2008-08-15
CPC分类号： G01N33/4833 , G01N33/493 , G01N33/57434 , G01N33/6806 , Y02A90/22 , Y02A90/26
摘要： The present invention relates to cancer markers. In particular, the present invention provides metabolites that are differentially present in prostate cancer.
摘要翻译： 本发明涉及癌症标志物。 特别地，本发明提供在前列腺癌中差异存在的代谢物。
-
公开(公告)号：US09250225B2
公开(公告)日：2016-02-02
申请号：US14324689
申请日：2014-07-07
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： G01N33/487 , G01N33/68 , G01N33/483 , G01N33/50
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance are provided, as well as methods for using the same as biomarkers for insulin resistance. Also provided are suites of small molecule entities as biomarkers for insulin resistance.
摘要翻译： 提供了与胰岛素抵抗有关的生物标志物，以及将其用于胰岛素抵抗的生物标志物的方法。 还提供了小分子实体的套件作为胰岛素抵抗的生物标志物。
-
公开(公告)号：US20130338031A1
公开(公告)日：2013-12-19
申请号：US13966475
申请日：2013-08-14
申请人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
发明人： Yun Fu Hu , Costel Chirila , Danny Alexander , Michael Milburn , Matthew W. Mitchell , Walter Gall , Kay A. Lawton
IPC分类号： G01N33/483 , G01N33/50
CPC分类号： G01N33/5308 , G01N33/483 , G01N33/487 , G01N33/5091 , G01N33/6893 , G01N2800/04 , G01N2800/042 , G01N2800/044 , G01N2800/32 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： Biomarkers relating to insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy are provided, as well as methods for using such biomarkers as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy. In addition, methods for modulating the respective disorders or conditions of a subject are also provided. Also provided are suites of small molecule entities as biomarkers for insulin resistance, pre-diabetes, type-2 diabetes, metabolic syndrome, atherosclerosis, and cardiomyopathy.
-
公开(公告)号：US08518650B2
公开(公告)日：2013-08-27
申请号：US12441945
申请日：2007-09-18
IPC分类号： G01N33/53
CPC分类号： G01N33/68 , G01N33/57434 , G01N33/6812 , Y10T436/173845 , Y10T436/201666
摘要： Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.
摘要翻译： 提供了用于鉴定和评估用作用于早期预测前列腺癌，疾病分级，靶标鉴定/验证和药物功效监测的生物标志物的生物化学和/或基因实体的套件的方法。 还提供了小分子实体的套件作为前列腺癌的生物标志物。
-
公开(公告)号：US20100292331A1
公开(公告)日：2010-11-18
申请号：US12441945
申请日：2007-09-18
申请人： Matthew W. Mitchell , Alvin Berger , Kay A. Lawton
发明人： Matthew W. Mitchell , Alvin Berger , Kay A. Lawton
IPC分类号： A61K31/195 , C12Q1/02 , G01N33/00 , G01N33/53 , A61K31/194 , A61K31/132 , A61P35/04
CPC分类号： G01N33/68 , G01N33/57434 , G01N33/6812 , Y10T436/173845 , Y10T436/201666
摘要： Methods for identifying and evaluating suites of biochemical and/or gene entities useful as biomarkers for early prediction of prostate cancer, disease grading, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for prostate cancer.
摘要翻译： 提供了用于鉴定和评估用作用于早期预测前列腺癌，疾病分级，靶标鉴定/验证和药物功效监测的生物标志物的生物化学和/或基因实体的套件的方法。 还提供了小分子实体的套件作为前列腺癌的生物标志物。
-
公开(公告)号：US20140343865A1
公开(公告)日：2014-11-20
申请号：US14362943
申请日：2012-12-07
申请人： Meredith V. Brown , Kay A. Lawton , Bruce Neri , Yang Chen
发明人： Meredith V. Brown , Kay A. Lawton , Bruce Neri , Yang Chen
IPC分类号： G01N33/574 , G06F19/12
CPC分类号： G01N33/57438 , G01N33/5011 , G01N2800/52 , G01N2800/56 , G01N2800/60 , G16B5/00
摘要： Methods for identifying and evaluating biochemical entities useful as biomarkers for kidney cancer, target identification/validation, and monitoring of drug efficacy are provided. Also provided are suites of small molecule entities as biomarkers for kidney cancer.
摘要翻译： 提供了用于鉴定和评估可用作肾癌生物标志物的生物化学实体的方法，靶标鉴定/验证和药物疗效监测。 还提供了小分子实体的套件作为肾癌的生物标志物。
-
公开(公告)号：US08658351B2
公开(公告)日：2014-02-25
申请号：US13148082
申请日：2010-02-05
申请人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
发明人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
IPC分类号： C12Q1/00
CPC分类号： G01N33/5014 , G01N33/5067 , G01N33/5088
摘要： The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant.
摘要翻译： 本发明提供用于肝毒性的各种生物标志物和使用生物标志物的各种方法本发明范围内的一些生物标志物是胆酸，甘油脱氧胆酸，甘氨胆酸，牛磺酸，3-羟基-2-乙基丙酸酯，4-咪唑乙酸酯，酪胺，邻氨基苯甲酸酯， 2'-脱氧胞苷，N-乙酰天冬氨酸（NAA），β-羟基己酸酯和肌氨酸（N-甲基甘氨酸）使用生物标志物的方法包括将第一肝细胞培养物暴露于测试试剂，并比较其中一种或多种 在第一肝细胞培养物中获得的更多生物标志物在没有测试剂的第二肝细胞培养物中获得的一种或多种生物标志物的水平，其中第一肝细胞培养物中的一种或多种生物标志物的差异水平与第二次肝细胞培养物中的水平相比 肝细胞培养表明试验剂是肝毒性剂。
-
公开(公告)号：US20110300571A1
公开(公告)日：2011-12-08
申请号：US13148082
申请日：2010-02-05
申请人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
发明人： Michael Milburn , Lining Guo , Jacob Edward Wulff , Kay A. Lawton
CPC分类号： G01N33/5014 , G01N33/5067 , G01N33/5088
摘要： The present invention provides various biomarkers for hepatotoxicity and various methods of using the biomarkers Some of the biomarkers within the scope of this invention are cholate, glycochenodeoxycholate, glycocholate, taurine, 3-hyroxy-2-ethylpropionate, 4-imidazoleacetate, tyramine, anthranilate, 2′-deoxycytidine, N-acetyl aspartate (NAA), beta-hydroxy-hexanoate, and sarcosine (N-methylglycine) The methods of using the biomarkers include exposing a first hepatocyte culture to a test agent and comparing the levels of the one or more biomarkers obtained in the first hepatocyte culture to the levels of the one or more biomarkers obtained in a second hepatocyte culture without the test agent, where differential levels of the one or more biomarkers in the first hepatocyte culture as compared to the levels in the second hepatocyte culture is indicative of the test agent being a hepatotoxicant.
摘要翻译： 本发明提供用于肝毒性的各种生物标志物和使用生物标志物的各种方法本发明范围内的一些生物标志物是胆酸，甘油脱氧胆酸，甘氨胆酸，牛磺酸，3-羟基-2-乙基丙酸酯，4-咪唑乙酸酯，酪胺，邻氨基苯甲酸酯， 2'-脱氧胞苷，N-乙酰天冬氨酸（NAA），β-羟基己酸酯和肌氨酸（N-甲基甘氨酸）使用生物标志物的方法包括将第一肝细胞培养物暴露于测试试剂，并比较其中一种或多种 在第一肝细胞培养物中获得的更多生物标志物在没有测试剂的第二肝细胞培养物中获得的一种或多种生物标志物的水平，其中第一肝细胞培养物中的一种或多种生物标志物的差异水平与第二次肝细胞培养物中的水平相比 肝细胞培养表明试验剂是肝毒性剂。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.055 秒)
