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公开(公告)号：US20100041102A1
公开(公告)日：2010-02-18
申请号：US12312401
申请日：2007-11-02
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
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公开(公告)号：US08344114B2
公开(公告)日：2013-01-01
申请号：US13242744
申请日：2011-09-23
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（PCSK9）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，在治疗与PCSK9活性相关的病症中使用期望的拮抗剂是有用的。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20120082679A1
公开(公告)日：2012-04-05
申请号：US13242744
申请日：2011-09-23
IPC分类号： A61K39/395 , C12N15/13 , C12N15/63 , C12N5/10 , A61P3/00 , C12N1/21 , C12N1/19 , A61P7/00 , A61P9/00 , C07K16/40 , C12P21/02
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
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公开(公告)号：US20120077964A1
公开(公告)日：2012-03-29
申请号：US13246219
申请日：2011-09-27
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，在治疗与PCSK9活性相关的病症中使用期望的拮抗剂是有用的。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20100150937A1
公开(公告)日：2010-06-17
申请号：US12312399
申请日：2007-11-02
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，在治疗与PCSK9活性相关的病症中使用期望的拮抗剂是有用的。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。
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公开(公告)号：US20100136028A1
公开(公告)日：2010-06-03
申请号：US12312397
申请日：2007-11-02
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
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公开(公告)号：US20100040610A1
公开(公告)日：2010-02-18
申请号：US12312383
申请日：2007-11-02
申请人： Ayesha Sitlani , Carl P. Sparrow , Shilpa Pandit , Jon H. Condra , Dana D. Wood , Timothy S. Fisher
发明人： Ayesha Sitlani , Carl P. Sparrow , Shilpa Pandit , Jon H. Condra , Dana D. Wood , Timothy S. Fisher
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/74 , C12N5/07 , C12P21/02 , G01N33/53 , A61P35/00
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
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公开(公告)号：US20120082680A1
公开(公告)日：2012-04-05
申请号：US13242831
申请日：2011-09-23
申请人： Ayesha Sitlani , Carl P. Sparrow , Shilpa Pandit , Jon H. Condra , Dana D. Wood , Timothy S. Fisher
发明人： Ayesha Sitlani , Carl P. Sparrow , Shilpa Pandit , Jon H. Condra , Dana D. Wood , Timothy S. Fisher
IPC分类号： A61K39/395 , C12N15/13 , A61P7/00 , A61P9/00 , G01N21/64 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12Q1/02 , C07K16/40 , A61P3/00
CPC分类号： C07K16/40 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
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公开(公告)号：US20120219558A1
公开(公告)日：2012-08-30
申请号：US13497663
申请日：2010-09-15
申请人： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon , Fubao Wang
发明人： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon , Fubao Wang
CPC分类号： C07K16/40 , C07K2317/76
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (PCSK9) are disclosed. Said antagonists are effective in the inhibition of PCSK9 function and thereby provide compositions of matter useful for the treatment of conditions associated with PCSK9 activity. The present invention further discloses nucleic acids encoding PCSK9 antagonists as well as methods of making and using PCSK9 antagonists.
摘要翻译： 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（PCSK9）的拮抗剂。 所述拮抗剂在抑制PCSK9功能方面是有效的，从而提供可用于治疗与PCSK9活性相关的病症的物质组合物。 本发明还公开了编码PCSK9拮抗剂的核酸以及制备和使用PCSK9拮抗剂的方法。
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公开(公告)号：US20110306060A1
公开(公告)日：2011-12-15
申请号：US13139045
申请日：2009-12-02
申请人： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon
发明人： Yan Ni , Ayesha Sitlani , Shilpa Pandit , Dale Lewis , Xun Shen , Sharon Lobo , Timothy McCabe , Jon Condra , Rose Cubbon
IPC分类号： G01N33/573
CPC分类号： C07K16/40 , C07K2317/55 , G01N33/543 , G01N33/573 , G01N2333/96433
摘要： Methods of using PCSK9 antagonists More specifically, methods for measuring circulating PCSK9 levels in a bio-logical sample by means of an immunoassay The immunoassay used can be a solid phase immunoassay, such as a dissociation-enhanced lanthanide fluorescence immunoassay utilizing an E07 capture antibody or coating and a G08 or H23 detecting antibody.
摘要翻译： 使用PCSK9拮抗剂的方法更具体地，通过免疫测定法测量生物逻辑样品中的循环PCSK9水平的方法所用的免疫测定可以是固相免疫测定法，例如利用E07捕获抗体的解离增强镧系荧光免疫测定法 涂层和G08或H23检测抗体。
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