公开(公告)号：US20130251723A1

公开(公告)日：2013-09-26

申请号：US13823999

申请日：2011-10-03

Applicant: Christian Rohlff ,  Alasdair Stamps ,  Jonathan Alexander Terrett

Inventor： Christian Rohlff ,  Alasdair Stamps ,  Jonathan Alexander Terrett

IPC: C07K16/40

CPC classification number: C07K16/40 ,  C07K16/005 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/77

Abstract: The invention provides antibodies which bind to the extracellular domain of the Tyrosine-protein kinase transmembrane receptor ROR1. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of cancer, including non-small cell lung carcinoma, B-cell chronic lymphocytic leukemia and colon cancer.

Abstract translation: 本发明提供结合酪氨酸 - 蛋白激酶跨膜受体ROR1的细胞外结构域的抗体。 还提供了编码抗体的核酸分子，表达载体，宿主细胞和用于表达抗体的方法。 抗体可用于治疗癌症，包括非小细胞肺癌，B细胞慢性淋巴细胞白血病和结肠癌。

公开(公告)号：US08535677B2

公开(公告)日：2013-09-17

申请号：US12958373

申请日：2010-12-01

Applicant: Christian Rohlff ,  Jonathan Alexander Terrett

Inventor： Christian Rohlff ,  Jonathan Alexander Terrett

IPC: A61K39/00

CPC classification number: G01N33/6893 ,  G01N33/57419 ,  G01N2500/04

Abstract: The present invention provides methods and compositions for the treatment of and for screening, diagnosis and prognosis of colorectal cancer, for monitoring the effectiveness of colorectal cancer treatment, and for drug development.

Abstract translation: 本发明提供了用于治疗结直肠癌筛查，诊断和预后的方法和组合物，用于监测结肠直肠癌治疗和药物开发的有效性。

公开(公告)号：US20120093826A1

公开(公告)日：2012-04-19

申请号：US13254752

申请日：2010-03-05

Applicant: Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

Inventor： Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

IPC: A61K39/395 ,  C12N15/13 ,  C12N15/63 ,  A61P35/02 ,  C12P21/08 ,  C12N5/16 ,  A61P35/00 ,  C07K16/28 ,  C12N5/10

CPC classification number: C07K16/3007 ,  A61K33/24 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  A61K2300/00

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

Abstract translation: 本公开内容提供分离的单克隆抗体，特别是人单克隆抗体，更特别是工程化的抗体，其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子，表达载体，宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法，以及用于治疗各种癌症的方法，包括肺癌和胰腺癌。

公开(公告)号：US20090246201A1

公开(公告)日：2009-10-01

申请号：US11893095

申请日：2007-08-14

Applicant: Edward Alexander McKenzie ,  Alasdair Craig Stamps ,  Jonathan Alexander Terrett ,  Kerry Louise Tyson

Inventor： Edward Alexander McKenzie ,  Alasdair Craig Stamps ,  Jonathan Alexander Terrett ,  Kerry Louise Tyson

IPC: A61K39/395 ,  C12N9/10 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  C12N5/06 ,  C12P21/02 ,  A61K38/45 ,  C12Q1/48

CPC classification number: C12Y302/01166 ,  C12N9/2402

Abstract: The present invention provides a homologue to heparanase which is present in three splice variants.

Abstract translation: 本发明提供了存在于三个剪接变体中的乙酰肝素酶的同源物。

公开(公告)号：US08680247B2

公开(公告)日：2014-03-25

申请号：US12668965

申请日：2008-07-17

Applicant: Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

Inventor： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Haichun Huang ,  Dapeng Yao ,  Chin Pan ,  Heidi Leblanc ,  Timothy Sproul ,  Mark Yamanaka

IPC: C07K16/30 ,  A61K39/395 ,  A61K39/44 ,  C07K16/46

CPC classification number: C07K16/28 ,  A61K39/00 ,  C07K16/303 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Glypican-3 with high affinity. Nucleic acid molecules encoding Glypican-3 antibodies, expression vectors, host cells and methods for expressing the Glypican-3 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the Glypican-3 antibodies are also provided. Methods for detecting Glypican-3, as well as methods for treating various Glypican-3-related conditions, including hepatocellular cancer, are disclosed.

Abstract translation: 本公开提供分离的单克隆抗体，特别是以高亲和力特异性结合磷脂酰肌醇蛋白聚糖-3的人单克隆抗体。 还提供了编码磷脂酰肌醇蛋白聚糖-3抗体的核酸分子，表达载体，宿主细胞和用于表达糖蛋白聚糖-3抗体的方法。 还提供了免疫偶联物，双特异性分子和包含磷脂酰肌醇蛋白聚糖-3抗体的药物组合物。 公开了检测磷酸三钙-3的方法，以及用于治疗各种磷酸三钙3相关病症（包括肝细胞癌）的方法。

公开(公告)号：US08420084B2

公开(公告)日：2013-04-16

申请号：US13254752

申请日：2010-03-05

Applicant: Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

Inventor： Jonathan Alexander Terrett ,  Heidi Leblanc ,  Haichun Huang ,  Erika Meaddough ,  Chin Pan ,  Bingliang Chen ,  Chetana Rao-Naik

IPC: A61K39/395 ,  C07K16/00 ,  C07K16/46

CPC classification number: C07K16/3007 ,  A61K33/24 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/3023 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  A61K2300/00

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, more particularly engineered antibodies resulting in increased binding to Fc receptors and/or increased potency for ADCC or immunoconjugates, which specifically bind to CADM1 with high affinity. Nucleic acid molecules encoding CADM1 antibodies, expression vectors, host cells and methods for expressing the CADM1 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the CADM1 antibodies are also provided. Methods for detecting CADM1, as well as methods for treating various cancers, including lung cancer and pancreatic cancer, are disclosed.

Abstract translation: 本公开内容提供分离的单克隆抗体，特别是人单克隆抗体，更特别是工程化的抗体，其导致与Fc受体的增加的结合和/或增加对具有高亲和力特异性结合CADM1的ADCC或免疫偶联物的效力。 还提供编码CADM1抗体的核酸分子，表达载体，宿主细胞和用于表达CADM1抗体的方法。 还提供了包含CADM1抗体的双特异性分子和药物组合物。 公开了用于检测CADM1的方法，以及用于治疗各种癌症的方法，包括肺癌和胰腺癌。

公开(公告)号：US20120114672A1

公开(公告)日：2012-05-10

申请号：US13265517

申请日：2010-04-20

Applicant: Christian Rohlff ,  Jonathan Alexander Terrett

Inventor： Christian Rohlff ,  Jonathan Alexander Terrett

IPC: A61K39/395 ,  C12N15/13 ,  C12N15/63 ,  C12N1/19 ,  C12P21/02 ,  A61P35/00 ,  C12N1/21 ,  C07K16/18 ,  C12N5/10

CPC classification number: C07K16/28 ,  A61K39/00 ,  A61K47/6817 ,  A61K47/6849 ,  A61K47/6851 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/77 ,  C07K2317/80

Abstract: The present disclosure provides antibodies, including isolated monoclonal antibodies, which specifically bind to Cadherin-17 with high affinity. Nucleic acid molecules encoding Cadherin-17 antibodies, expression vectors, host cells and methods for expressing the Cadherin-17 antibodies are also provided. Bispecific molecules and pharmaceutical compositions comprising the Cadherin-17 antibodies are also provided. Methods for detecting Cadherin-17, as well as methods for treating various cancers, including colorectal cancer, are disclosed.

Abstract translation: 本公开提供了抗体，包括分离的单克隆抗体，其以高亲和力特异性结合钙粘着蛋白-17。 还提供了编码钙粘蛋白-17抗体的核酸分子，表达载体，宿主细胞和用于表达钙粘着蛋白-17抗体的方法。 还提供了包含钙黏着蛋白-17抗体的双特异性分子和药物组合物。 公开了用于检测Cadherin-17的方法，以及用于治疗各种癌症的方法，包括结肠直肠癌。

公开(公告)号：US20100285017A1

公开(公告)日：2010-11-11

申请号：US12701566

申请日：2010-02-07

Applicant: Christian Rohlff ,  Jonathan Alexander Terrett

Inventor： Christian Rohlff ,  Jonathan Alexander Terrett

IPC: A61K39/395 ,  C07K16/30 ,  C07K14/435 ,  A61P35/00 ,  C07H21/04 ,  C12N15/63 ,  C12P21/08 ,  G01N33/573 ,  A61K38/17 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68

CPC classification number: G01N33/573 ,  C12Q1/37 ,  G01N33/574 ,  G01N2333/96433

Abstract: The present invention provides methods and compositions for treatment, screening, diagnosis, prognosis and therapy of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer, for monitoring the effectiveness of breast cancer, colorectal cancer, esophageal cancer, gastric cancer, prostate cancer and uterine cancer treatment, and for drug development.

Abstract translation: 本发明提供乳腺癌，结肠直肠癌，食管癌，胃癌，前列腺癌和子宫癌的治疗，筛选，诊断，预后和治疗的方法和组合物，用于监测乳腺癌，结肠直肠癌，食管癌， 胃癌，前列腺癌和子宫癌治疗，以及药物开发。

公开(公告)号：US09505845B2

公开(公告)日：2016-11-29

申请号：US13442499

申请日：2012-04-09

Applicant: Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

Inventor： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

IPC: A61K39/395 ,  C07K16/30 ,  C07K16/40 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/77

Abstract: The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Abstract translation: 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。

公开(公告)号：US09102738B2

公开(公告)日：2015-08-11

申请号：US13468624

申请日：2012-05-10

Applicant: Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

Inventor： Jonathan Alexander Terrett ,  Li-Sheng Lu ,  Chin Pan

IPC: C07K16/40 ,  C07K16/00 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/30 ,  A61K2039/505 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/77

Abstract: The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PTK7 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PTK7, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PTK7 antibodies.

Abstract translation: 本发明提供了以高亲和力特异性结合PTK7的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供用于检测PTK7的方法，以及使用抗PTK7抗体治疗各种疾病（包括癌症和感染性疾病）的方法。