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    MAGNETIC BEAD ACTUATION USING FEEDBACK FOR FTIR BIOSENSOR
    14.
    发明申请
    MAGNETIC BEAD ACTUATION USING FEEDBACK FOR FTIR BIOSENSOR 有权
    使用FTIR生物传感器反馈的磁珠执行

    公开(公告)号：US20100311183A1

    公开(公告)日：2010-12-09

    申请号：US12865864

    申请日：2009-02-02

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01N21/75

    CPC分类号： G01N33/54333 ,  G01N21/552 ,  G01N27/745 ,  G01N33/54373 ,  G01N35/0098

    摘要： The invention provides a method for controlling actuation of label particles in a biosensor device, in particular a biosensor device using frustrated total internal reflection. By applying a predetermined actuation force on the label particles and determining the effect of the applied actuation force in a binding volume or surface of a sensor cartridge of the biosensor device, a feedback control of the actuation force is applied. Furthermore, a biosensor device is provided which is adapted for forming the method according to the invention.

    摘要翻译： 本发明提供一种用于控制生物传感器装置中的标签颗粒致动的方法，特别是使用沮丧的全内反射的生物传感器装置。 通过对标签颗粒施加预定的致动力并确定所施加的致动力对生物传感器装置的传感器盒的装订体积或表面的影响，施加致动力的反馈控制。 此外，提供适于形成根据本发明的方法的生物传感器装置。

    EVANESCENT FIELD MODULATION IN A BIOSENSOR
    15.
    发明申请
    EVANESCENT FIELD MODULATION IN A BIOSENSOR 有权
    生物传感器中的EVANESCENT现场调制

    公开(公告)号：US20100290052A1

    公开(公告)日：2010-11-18

    申请号：US12810867

    申请日：2008-12-18

    申请人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Henricus Maria Kahlman

    发明人： Johannes Joseph Hubertina Barbara Schleipen ,  Dominique Maria Bruls ,  Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01N21/55

    CPC分类号： G01N21/552

    摘要： The present invention provides an FTIR system comprising a first light source emitting light of a first wavelength, a sample volume with an adjacent sensor surface, a detector for detecting light reflected at said sensor surface. The sensor surface is illuminated by said first light source fulfilling the condition of total internal reflection and generating an evanescent field with a decay length within the sample volume. The system further comprises means for changing the decay length of the evanescent field and means for correlating the detected signals with the change of the decay length of the evanescent field.

    摘要翻译： 本发明提供了一种FTIR系统，包括发射第一波长的光的第一光源，具有相邻传感器表面的样品体积，用于检测在所述传感器表面反射的光的检测器。 所述传感器表面由满足全内反射条件的所述第一光源照射，并产生具有在样品体积内的衰减长度的ev逝场。 该系统还包括用于改变ev逝场的衰减长度的装置和用于使检测到的信号与ev逝场的衰减长度变化相关联的装置。

    MAGNETIC SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES
    16.
    发明申请
    MAGNETIC SENSOR DEVICE FOR AND A METHOD OF SENSING MAGNETIC PARTICLES 审中-公开
    用于感应磁性颗粒的磁传感器装置和方法

    公开(公告)号：US20090278534A1

    公开(公告)日：2009-11-12

    申请号：US12305385

    申请日：2007-06-18

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01R33/09

    CPC分类号： G01R33/12 ,  B82Y25/00 ,  G01N15/0656 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/54373 ,  G01R33/09 ,  G01R33/093 ,  G01R33/1269

    摘要： A magnetic sensor device (300) for sensing magnetic particles (15), the magnetic sensor device (300) comprising a magnetic field generator unit (12) adapted for generating a plurality of different magnetic field configurations assigned to a plurality of different magnetic excitation states of the magnetic particles (15), a sensing unit (11) adapted for sensing a plurality of detection signals influenced by the magnetic particles (15) in the different magnetic field configurations, and a combining unit (30) adapted for combining the plurality of signals to thereby derive information indicative of the presence of the magnetic particles (15).

    摘要翻译： 一种用于感测磁性颗粒（15）的磁性传感器装置（300），该磁性传感器装置（300）包括一个适于产生分配给多个不同磁激励状态的多个不同磁场配置的磁场发生器单元（12） 的磁性颗粒（15）的感测单元（11），适用于感测由不同磁场结构中的磁性颗粒（15）影响的多个检测信号的感测单元（11），以及组合单元（30） 信号，从而导出指示磁性颗粒（15）的存在的信息。

    METHOD AND DEVICE FOR CHARACTERIZATION OF A MAGNETIC FIELD APPLIED TO A MAGNETIC SENSOR
    17.
    发明申请
    METHOD AND DEVICE FOR CHARACTERIZATION OF A MAGNETIC FIELD APPLIED TO A MAGNETIC SENSOR 审中-公开
    用于磁性传感器的磁场特性的方法和装置

    公开(公告)号：US20090243594A1

    公开(公告)日：2009-10-01

    申请号：US11721573

    申请日：2005-12-20

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01R33/09 ,  G01R35/00 ,  G01R33/02

    CPC分类号： G01R33/093 ,  B82Y25/00 ,  G01N27/745 ,  G01N35/0098 ,  G01R33/09 ,  G01R33/12 ,  G01R33/1269

    摘要： The present invention provides a magnetic sensor device comprising a plurality of magnetic sensor elements having a sensitive direction. At least one of the magnetic sensor elements (43) is provided with a flux-guide (44) for concentrating onto the sensor element in its sensitive direction a magnetic field applied to the magnetic sensor device. The applied magnetic field is thus bent into the sensitive direction of the magnetic sensor element by the flux-guide. In that way, the field strength and/or orientation of the applied magnetic field can be measured in the absence of magnetic particles. This may be used for, for example, calibration of magnetic sensor devices.

    摘要翻译： 本发明提供一种包括具有敏感方向的多个磁传感器元件的磁传感器装置。 磁传感器元件（43）中的至少一个设置有磁通（44），用于在其敏感方向上将传感器元件集中在施加到磁传感器装置的磁场上。 所施加的磁场因此通过磁通引导件弯曲成磁传感器元件的敏感方向。 以这种方式，可以在没有磁性颗粒的情况下测量施加的磁场的场强和/或取向。 这可以用于例如磁传感器装置的校准。

    SENSOR DEVICE WITH ADAPTIVE FIELD COMPENSATION
    19.
    发明申请
    SENSOR DEVICE WITH ADAPTIVE FIELD COMPENSATION 审中-公开
    具有自适应场补偿的传感器装置

    公开(公告)号：US20090184706A1

    公开(公告)日：2009-07-23

    申请号：US12302046

    申请日：2007-05-11

    申请人： Haris Duric ,  Josephus Arnoldus Henricus Maria Kahlman

    发明人： Haris Duric ,  Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： G01N27/72 ,  G01R35/00

    CPC分类号： G01R33/093 ,  B82Y25/00 ,  G01N27/745 ,  G01N33/54326 ,  G01R33/12 ,  G01R33/1269

    摘要： The invention relates to a magnetic sensor device comprising an excitation wire for the generation of an alternating magnetic excitation field (Bi) and a GMR sensor (12) for sensing reaction fields (B2) generated by magnetized particles (2) in reaction to the excitation fields. Moreover, it comprises a compensator (15) for the generation of a magnetic compensation field (B3) that adaptively cancels predetermined spectral components of all magnetic fields (B2, B3) which lie in the sensitive direction of the magnetic sensor element (12). Measurements of the GMR sensor (12) are thus made robust against gain variations of the sensor.

    摘要翻译： 本发明涉及一种磁传感器装置，包括用于产生交变磁场（Bi）的激励线和用于感测由激磁颗粒（2）产生的反应场（B2）的GMR传感器（12） 领域。 此外，它包括用于产生磁补偿场（B3）的补偿器（15），其自动地消除位于磁传感器元件（12）的敏感方向上的所有磁场（B2，B3）的预定频谱分量。 因此，GMR传感器（12）的测量对于传感器的增益变化是鲁棒的。

    Bit-detection arrangement and apparatus for reproducing information
    20.
    发明授权
    Bit-detection arrangement and apparatus for reproducing information 失效
    位检测装置和用于再现信息的装置

    公开(公告)号：US07430239B2

    公开(公告)日：2008-09-30

    申请号：US10496709

    申请日：2002-10-24

    申请人： Josephus Arnoldus Henricus Maria Kahlman

    发明人： Josephus Arnoldus Henricus Maria Kahlman

    IPC分类号： H04B14/06

    CPC分类号： H04L7/0334 ,  H03L7/0991

    摘要： A preprocessing unit converts an analog signal to a processed signal at a sample rate controlled by a first clock signal. A digital phase locked loop locks on the processed signal and outputs a phase signal using the first clock signal. A bit decision unit outputs a digital signal and a third clock signal using the phase signal, the first clock signal and an output signal from the preprocessing unit. A clock divider produces the first clock signal from the second clock signal. A quantizer produces the output signal by quantizing the analog signal amplitude. A phase detector determines a phase difference between the output signal and the second clock signal to feed an amplitude that indicates a phase difference. A sample and hold unit samples the output signal using the second clock signal and holds samples of the output signal for a clock period of first clock signal.

    摘要翻译： 预处理单元以由第一时钟信号控制的采样率将模拟信号转换为处理的信号。 数字锁相环锁定处理后的信号，并使用第一个时钟信号输出相位信号。 位判定单元使用相位信号，第一时钟信号和来自预处理单元的输出信号输出数字信号和第三时钟信号。 时钟分频器从第二个时钟信号产生第一个时钟信号。 量化器通过量化模拟信号幅度来产生输出信号。 相位检测器确定输出信号和第二时钟信号之间的相位差，以馈送指示相位差的幅度。 采样和保持单元使用第二时钟信号对输出信号进行采样，并在第一时钟信号的时钟周期内保持输出信号的采样。