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45 条记录 (耗时 0.044 秒)

    Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists
    13.
    发明授权
    Cyclic amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists 失效
    取代喹喔啉2,3-二酮的环胺衍生物作为谷氨酸受体拮抗剂

    公开(公告)号：US6110911A

    公开(公告)日：2000-08-29

    申请号：US272482

    申请日：1999-03-19

    申请人： Brian Edward Kornberg ,  Sham Shridhar Nikam ,  Michael Francis Rafferty ,  Po-Wai Yuen

    发明人： Brian Edward Kornberg ,  Sham Shridhar Nikam ,  Michael Francis Rafferty ,  Po-Wai Yuen

    IPC分类号： C07D241/44 ,  A61K31/4985 ,  A61K31/55

    CPC分类号： C07D241/44

    摘要： A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, seizure disorders, pain, Alzheimer's, Parkinson's, and Huntington's Diseases.

    摘要翻译： 教导了一系列用作神经保护剂的取代喹喔啉2,3-二酮。 还教导了新的中间体，制备方法和含有这些化合物的药物组合物。 这些化合物是谷氨酸拮抗剂，可用于治疗由血栓栓塞或出血性脑卒中，脑血管痉挛，低血糖症，心脏骤停，癫痫持续状态，围产期窒息，缺氧，癫痫发作，疼痛，阿尔茨海默病， 帕金森病和亨廷顿疾病。

    Therapeutic pyrazolo[3,4-B]pyridines and indazoles
    17.
    发明申请
    Therapeutic pyrazolo[3,4-B]pyridines and indazoles 有权
    治疗吡唑并[3,4-B]吡啶和吲唑

    公开(公告)号：US20060116376A1

    公开(公告)日：2006-06-01

    申请号：US11287759

    申请日：2005-11-28

    申请人： Robert Schelkun ,  Po-Wai Yuen

    发明人： Robert Schelkun ,  Po-Wai Yuen

    IPC分类号： A61K31/5377 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/416 ,  C07D413/14 ,  C07D471/02 ,  C07D403/02

    CPC分类号： C07D231/56 ,  C07D401/04 ,  C07D403/12 ,  C07D413/12 ,  C07D471/04

    摘要： The present invention provides for compounds of Formula I: wherein R2, R3, R4, R5, R6, R7, X, and L have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of central nervous disorders and conditions including attention deficit hyperactivity disorder, neuropathic pain, urinary incontinence, anxiety, depression, and schizophrenia and fibromyalgia. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.

    摘要翻译： 本发明提供式I化合物：其中R 2，R 3，R 4，R 5， R 6，R 7，X和L具有说明书中定义的任何值及其药学上可接受的盐，其可用作治疗 中枢神经障碍和包括注意缺陷多动障碍，神经性疼痛，尿失禁，焦虑，抑郁和精神分裂症以及纤维肌痛的疾病。 还提供了包含一种或多种式I化合物的药物组合物。

    Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof
    20.
    发明授权
    Substituted quinolines and isoquinolines as calcium channel blockers, their preparation and the use thereof 失效
    取代的喹啉和异喹啉作为钙通道阻滞剂，其制备及其用途

    公开(公告)号：US5932573A

    公开(公告)日：1999-08-03

    申请号：US40177

    申请日：1998-03-17

    申请人： Po-Wai Yuen

    发明人： Po-Wai Yuen

    IPC分类号： C07D217/04 ,  C07D217/10 ,  A61K31/535 ,  C07D498/00

    CPC分类号： C07D217/04 ,  C07D217/10

    摘要： The present invention relates to novel substituted quinolines and isoquinolines and derivatives thereof useful in the treatment of neurological disorders. Methods of preparing the compounds, intermediates useful in the preparation and pharmaceutical compositions containing the compounds are also included. The compounds are useful in treating pain, cerebral ischemia, and other cerebrovascular disorders.

    摘要翻译： 本发明涉及用于治疗神经障碍的新型取代喹啉和异喹啉及其衍生物。 制备化合物的方法，可用于制备的中间体和含有化合物的药物组合物也包括在内。 该化合物可用于治疗疼痛，脑缺血和其他脑血管障碍。