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11.发明公开公开(公告)号：US20240115680A1
公开(公告)日：2024-04-11
申请号：US18541798
申请日：2023-12-15
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
CPC分类号： A61K39/001102 , A61K38/1796 , A61K39/0011 , A61P35/00 , C07K14/723 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/892
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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12.发明授权公开(公告)号：US11865166B2
公开(公告)日：2024-01-09
申请号：US16328404
申请日：2017-08-29
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
CPC分类号： A61K39/001102 , A61K38/1796 , A61K39/0011 , A61P35/00 , C07K14/723 , A61K2039/5256 , A61K2039/53 , A61K2039/572 , A61K2039/892
摘要： Provided herein is an immunogenic composition comprising a synthetic consensus antigen to Follicle Stimulating Hormone Receptor (FSHR) protein which is abundant in many ovarian cancer sub-types. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
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公开(公告)号：US20230203133A1
公开(公告)日：2023-06-29
申请号：US17997963
申请日：2021-05-06
发明人： Kar Muthumani , David Weiner
CPC分类号： C07K16/082 , A61P31/20 , C12N15/63 , A61K45/06
摘要： Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Hepatitis B viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Hepatitis B virus infection in a subject using said composition and method of generation.
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公开(公告)号：US20220370598A1
公开(公告)日：2022-11-24
申请号：US17662141
申请日：2022-05-05
发明人： Jian Yan , Kate Broderick , David Weiner , Kar Muthumani , Ami Patel
IPC分类号： A61K39/215 , A61P31/14 , A61K9/00
摘要： Provided herein are methods of inducing an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in a subject in need thereof by administering an immunogenic composition to the subject, wherein the subject exhibits: an increase in antigen-specific cellular immune response as measured by Interferon-gamma (IFN-γ) Enzyme-linked Immunospot (ELISpot) assay relative to baseline; and/or an increase in neutralizing antibody response as measured by a pseudovirus neutralizing assay relative to baseline.
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15.发明申请公开(公告)号：US20220098324A1
公开(公告)日：2022-03-31
申请号：US17427434
申请日：2020-01-30
摘要： Disclosed herein are compositions comprising a recombinant nucleic acid sequence encoding a bispecific immune cell engaging antibody (DICE), a recombinant nucleic acid sequence encoding a bispecific T cell engaging (DBiTE) antibody, a fragment thereof, a variant thereof, or a combination thereof.
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公开(公告)号：US20220054620A1
公开(公告)日：2022-02-24
申请号：US17416199
申请日：2019-12-20
发明人： Kar Muthumani , David Weiner , Hyeree Choi , Sagar B. Kudchodkar
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing at least one Powassan virus (POWV) antigen that elicits an immune response in a mammal against POWV virus, and methods of use thereof.
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17.发明申请公开(公告)号：US20190290751A1
公开(公告)日：2019-09-26
申请号：US16465691
申请日：2017-12-01
发明人： David Weiner , Ami Patel , Sarah Elliott
IPC分类号： A61K39/12 , A61P31/14 , A61P37/04 , C07K14/005
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
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公开(公告)号：US20240269267A1
公开(公告)日：2024-08-15
申请号：US18566859
申请日：2022-06-03
发明人： David Weiner , Pratik Bhojnagarwala , Ebony Gary
IPC分类号： A61K39/295 , A61K39/00 , A61P31/16 , A61P31/22
CPC分类号： A61K39/295 , A61P31/16 , A61P31/22 , A61K2039/53 , A61K2039/572 , C12N2710/16134 , C12N2710/16634 , C12N2730/10134 , C12N2740/13034 , C12N2760/16134 , C12N2760/18534 , C12N2760/20234 , C12N2770/24234
摘要： Disclosed herein is a composition comprising one or more viral antigen or a recombinant nucleic acid sequence that encodes one or more viral antigen with enhanced immunogenicity in vivo. Also disclosed herein is a method of generating an immune response in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a viral infection in a subject using said composition and methods.
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19.发明公开公开(公告)号：US20240148854A1
公开(公告)日：2024-05-09
申请号：US18552635
申请日：2022-03-28
发明人： David Weiner , Kevin Liaw , Daniel Kulp , Nicholas Tursi , Ziyang Xu
IPC分类号： A61K39/12 , A61K41/00 , A61P31/20 , A61P37/04 , C07K14/005
CPC分类号： A61K39/12 , A61K41/0047 , A61P31/20 , A61P37/04 , C07K14/005
摘要： Disclosed herein are nanoparticles comprising one or more Human papillomavirus (HPV) antigen and nucleic acid molecules encoding the same. Also disclosed herein is a method of treating a HPV infection or treating or preventing a disease or disorder associated therewith in a subject in need thereof, by administering the nanoparticles, or encoding nucleic acid molecules, to the subject.
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20.发明公开公开(公告)号：US20240131154A1
公开(公告)日：2024-04-25
申请号：US18477785
申请日：2023-09-28
申请人： The Trustees of the University of Pennsylvania , Inovio Pharmaceuticals, Inc. , The Wistar Institute of Anatomy and Biology
发明人： David Weiner , Karuppiah Muthumani , Jian Yan
CPC分类号： A61K39/42 , A61K39/12 , A61P31/14 , C07K14/18 , C07K16/10 , C07K16/1081 , A61K2039/53
摘要： Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
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