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23 条记录 (耗时 0.048 秒)

    Biarylurea derivatives
    13.
    发明申请
    Biarylurea derivatives 失效
    双芳脲衍生物

    公开(公告)号：US20070027147A1

    公开(公告)日：2007-02-01

    申请号：US11002422

    申请日：2004-12-03

    申请人： Takashi Hayama ,  Kyoko Hayashi ,  Teruki Honma ,  Ikuko Takahashi

    发明人： Takashi Hayama ,  Kyoko Hayashi ,  Teruki Honma ,  Ikuko Takahashi

    IPC分类号： A61K31/538 ,  A61K31/4545 ,  A61K31/4439 ,  C07D413/14 ,  C07D403/14

    CPC分类号： C07D213/75 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D231/40 ,  C07D239/42 ,  C07D241/20 ,  C07D277/48 ,  C07D277/54 ,  C07D277/56 ,  C07D277/82 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

    摘要： The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

    摘要翻译： 本发明涉及式（I）化合物及其制备方法及其用途：式（I）其中：Ar为含氮杂芳环; X和Z各自为碳原子，等等; Y是CO，等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子，等等; “img id =”custom-character-00001“he =”3.13mm“wi =”6.01mm“file =”US20070027147A1-20070201-P00001.TIF“alt =”custom character“img-content =”character“ img-format =“tif”/>是单键或双键。 根据本发明，本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂，因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。

    Pyrazinone derivatives
    14.
    发明授权
    Pyrazinone derivatives 失效
    吡嗪酮衍生物

    公开(公告)号：US07148224B2

    公开(公告)日：2006-12-12

    申请号：US11105534

    申请日：2005-04-14

    申请人： Takashi Hayama ,  Nobuhiko Kawanishi ,  Tooru Takaki

    发明人： Takashi Hayama ,  Nobuhiko Kawanishi ,  Tooru Takaki

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D471/00

    CPC分类号： C07D213/75 ,  C07D277/48 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

    摘要： The present invention relates to a compound of the general formula (I): [Ar1 is aryl fused to the adjacent pyrazinone ring at the 5th and 6th positions, etc., X is CO, etc., Y is CH, etc., Z is CH, etc., V is CH, etc., Wn is —(CH2)n— (n is zero to four), R1, is H or optionally substituted lower alkyl, etc., R2 is H, etc., R3 and R4 are the same or different and are each H, etc., R5 and R6 are the same or different and are each H, hydroxy, etc.] or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition, an inhibitor of Cdk4 and/or Cdk6 or an anti-cancer agent, containing the same as an active ingredient; and a process for preparing them.

    摘要翻译： 本发明涉及通式（I）的化合物：[Ar 1]在第5和6位与相邻的吡嗪酮环稠合的芳基等，X是CO等， Y是CH等，Z是CH等，V是CH等，W n是 - （CH 2）n

    Plant which belongs to the genus limonium and a method for creating the same
    16.
    发明授权
    Plant which belongs to the genus limonium and a method for creating the same 失效
    属于lim草的植物及其生产方法

    公开(公告)号：US06310276B1

    公开(公告)日：2001-10-30

    申请号：US09144037

    申请日：1998-08-31

    申请人： Masahiro Nakagawa ,  Takashi Hayama

    发明人： Masahiro Nakagawa ,  Takashi Hayama

    IPC分类号： A01H500

    CPC分类号： A01H6/30 ,  A01H5/02

    摘要： A plant which belongs to the genus Limonium, having a characteristic of undergoing flower bud differentiation and flower stalk development within 50 days from seeding even without low temperatures of 25° C. or below; and a method for creating the plant are disclosed.

    摘要翻译： 属于Limonium属的植物，即使没有25℃或更低的低温，也能播种后的50天内进行花芽分化和花茎发育的特征; 并且公开了一种用于创建植物的方法。

    Biarylurea derivatives
    18.
    发明授权
    Biarylurea derivatives 失效
    双芳脲衍生物

    公开(公告)号：US07354946B2

    公开(公告)日：2008-04-08

    申请号：US11002422

    申请日：2004-12-03

    申请人： Takashi Hayama ,  Kyoko Hayashi ,  Teruki Honma ,  Ikuko Takahashi

    发明人： Takashi Hayama ,  Kyoko Hayashi ,  Teruki Honma ,  Ikuko Takahashi

    IPC分类号： C07D498/04 ,  C07D405/12 ,  A61K31/423 ,  A61K31/424

    CPC分类号： C07D213/75 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D231/40 ,  C07D239/42 ,  C07D241/20 ,  C07D277/48 ,  C07D277/54 ,  C07D277/56 ,  C07D277/82 ,  C07D401/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

    摘要： The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof:Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

    摘要翻译： 本发明涉及式（I）化合物及其制备方法及其用途：式（I）其中：Ar为含氮杂芳环; X和Z各自为碳原子，等等; Y是CO，等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子，等等; “img id =”CUSTOM-CHARACTER-00001“he =”3.13mm“wi =”6.01mm“file =”US07354946-20080408-​​P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/>是单键或双键。 根据本发明，本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂，因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。