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公开(公告)号：US08465922B2
公开(公告)日：2013-06-18
申请号：US13217112
申请日：2011-08-24
申请人： John Eid , Stephen Turner
发明人： John Eid , Stephen Turner
CPC分类号： G01N33/58 , B01J2219/00693 , B01J2219/00702 , C12Q1/6837 , C40B60/10 , C40B60/12 , C12Q2537/143 , C12Q2565/102
摘要： Methods and systems for monitoring reactions by observing signals deriving from those reactions, using signal processing that allows differentiation between signals that are otherwise optically overlapping by conventional detection methods. Centroid determination is used to identify signal sources that are presenting confounding overlapping signals due to their physical proximity, and/or to identify discrete signals from different reaction centers.
摘要翻译： 通过观察来自这些反应的信号来监测反应的方法和系统，使用允许通过常规检测方法光学重叠的信号之间的区别的信号处理。 质心确定用于识别由于其物理接近性而呈现混杂重叠信号的信号源，和/或识别来自不同反应中心的离散信号。
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公开(公告)号：US20120028250A1
公开(公告)日：2012-02-02
申请号：US13191256
申请日：2011-07-26
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译： 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
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公开(公告)号：US07998717B2
公开(公告)日：2011-08-16
申请号：US11293040
申请日：2005-12-02
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/10
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
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公开(公告)号：US07960116B2
公开(公告)日：2011-06-14
申请号：US12212313
申请日：2008-09-17
申请人： John Eid , Alex Dewinter
发明人： John Eid , Alex Dewinter
CPC分类号： C12Q1/6869 , C12Q2521/319
摘要： Sequencing methods that use an exonuclease that comprises template dependent nucleobase binding activity are provided. Related compositions and sequencing systems are also provided.
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公开(公告)号：US20120052490A1
公开(公告)日：2012-03-01
申请号：US13217112
申请日：2011-08-24
申请人： John Eid , Stephen Turner
发明人： John Eid , Stephen Turner
IPC分类号： C12Q1/68
CPC分类号： G01N33/58 , B01J2219/00693 , B01J2219/00702 , C12Q1/6837 , C40B60/10 , C40B60/12 , C12Q2537/143 , C12Q2565/102
摘要： Methods and systems for monitoring reactions by observing signals deriving from those reactions, using signal processing that allows differentiation between signals that are otherwise optically overlapping by conventional detection methods. Centroid determination is used to identify signal sources that are presenting confounding overlapping signals due to their physical proximity, and/or to identify discrete signals from different reaction centers.
摘要翻译： 通过观察来自这些反应的信号来监测反应的方法和系统，使用允许通过常规检测方法光学重叠的信号之间的区别的信号处理。 质心确定用于识别由于其物理接近性而呈现混杂重叠信号的信号源，和/或识别来自不同反应中心的离散信号。
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公开(公告)号：US20110256618A1
公开(公告)日：2011-10-20
申请号：US13068045
申请日：2011-04-28
申请人： John Eid , Alex Dewinter
发明人： John Eid , Alex Dewinter
IPC分类号： C12M1/34
CPC分类号： C12Q1/6869 , C12Q2521/319
摘要： Sequencing methods that use an exonuclease that comprises template dependent nucleobase binding activity are provided. Related compositions and sequencing systems are also provided.
摘要翻译： 提供了使用包含模板依赖性核碱基结合活性的外切核酸酶的测序方法。 还提供了相关的组合物和测序系统。
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公开(公告)号：US08415128B2
公开(公告)日：2013-04-09
申请号：US13191256
申请日：2011-07-26
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/10
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译： 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
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公开(公告)号：US08304191B2
公开(公告)日：2012-11-06
申请号：US13068045
申请日：2011-04-28
申请人： John Eid , Alex Dewinter
发明人： John Eid , Alex Dewinter
CPC分类号： C12Q1/6869 , C12Q2521/319
摘要： Sequencing methods that use an exonuclease that comprises template dependent nucleobase binding activity are provided. Related compositions and sequencing systems are also provided.
摘要翻译： 提供了使用包含模板依赖性核碱基结合活性的外切核酸酶的测序方法。 还提供了相关的组合物和测序系统。
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公开(公告)号：US08071346B2
公开(公告)日：2011-12-06
申请号：US11981626
申请日：2007-10-31
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/96
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译： 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
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公开(公告)号：US07993895B2
公开(公告)日：2011-08-09
申请号：US11566153
申请日：2006-12-01
申请人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
发明人： John Eid , Devon Murphy , Geoffrey Otto , Stephen Turner
IPC分类号： C12N9/10
CPC分类号： A61K38/446 , A61K38/063 , A61K38/443 , G01N33/582
摘要： Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating different observation regions of the reaction mixture for a period that is less than a photodamage threshold period.
摘要翻译： 用于通过一种或多种在反应混合物中掺入光损伤缓和剂和/或在反应混合物中询问不同观察区域一段时间来减少和/或防止一种或多种反应物在照明分析反应中的光损伤的组合物，装置，系统和方法 这小于光损伤阈值期。
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