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公开(公告)号：US07847068B2
公开(公告)日：2010-12-07
申请号：US11598520
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
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公开(公告)号：US20090324605A1
公开(公告)日：2009-12-31
申请号：US12551250
申请日：2009-08-31
IPC分类号： A61K39/395 , C07K16/24 , A61P3/10 , A61P19/02 , C07H21/04 , C12N15/63 , C12N5/10 , A01K67/027 , C12N5/12
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。
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公开(公告)号：US09758593B2
公开(公告)日：2017-09-12
申请号：US11788808
申请日：2007-04-20
CPC分类号： C07K16/44 , A61K2039/505 , C07K2317/24 , C07K2317/92
摘要： Methods for treating a cocaine-related disorder in an individual include administering to the individual a therapeutic amount of an antibody comprising a human immunoglobulin gamma heavy chain and a murine lambda light chain. In another embodiment, the light chain includes a human kappa light chain at least partially derived from 1B3. Other embodiments are directed toward the antibodies themselves and methods of binding the antibodies.
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公开(公告)号：US08173779B2
公开(公告)日：2012-05-08
申请号：US12941617
申请日：2010-11-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： C12P21/08
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US20070059305A1
公开(公告)日：2007-03-15
申请号：US11598618
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
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公开(公告)号：US07741449B2
公开(公告)日：2010-06-22
申请号：US11009410
申请日：2004-12-10
IPC分类号： C07K16/00 , C07K16/24 , A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
摘要： The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
摘要翻译： 本发明提供分离的抗干扰素α单克隆抗体，特别是人单克隆抗体，其抑制多种干扰素（IFN）α亚型的生物学活性，但基本上不抑制IFNα21的生物活性或IFNβ的生物学活性 或IFNγ。 还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。 本发明还提供了使用本发明的抗体抑制IFNα的生物学活性的方法，以及通过施用本发明的抗体来治疗由IFNα介导的疾病或病症的方法，例如自身免疫疾病，移植排斥反应和移植物抗宿主病 本发明的抗体。
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公开(公告)号：US07667021B2
公开(公告)日：2010-02-23
申请号：US11598618
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes isolated nucleic acids encoding fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括编码针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体的分离的核酸。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US20080014197A1
公开(公告)日：2008-01-17
申请号：US11835791
申请日：2007-08-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395 , A61P35/00 , A61P9/10 , C07K16/22
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US07217796B2
公开(公告)日：2007-05-15
申请号：US10443466
申请日：2003-05-22
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US3965375A
公开(公告)日：1976-06-22
申请号：US560332
申请日：1975-03-21
CPC分类号： G02F1/3551
摘要： The nonlinear properties of LiClO.sub.4.3H.sub.2 O permit noncritical phase matching in the vicinity of 5200 Angstroms at room temperature. This material may be used as the essential element in second harmonic generators and other nonlinear devices which could then be operated at room temperature under noncritical phase-matched conditions.
摘要翻译： LiClO4.3H2O的非线性特性允许在室温下在5200埃附近进行非临界相匹配。 这种材料可以用作二次谐波发生器和其他非线性装置中的基本元件，然后可以在室温下在非临界相位匹配条件下操作。
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