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公开(公告)号：US20070059305A1
公开(公告)日：2007-03-15
申请号：US11598618
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
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公开(公告)号：US20070059241A1
公开(公告)日：2007-03-15
申请号：US11598520
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K51/00 , A61K39/395 , A61K31/7072 , A61K31/704 , A61K31/7048 , A61K38/21 , A61K38/16
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
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公开(公告)号：US20080014197A1
公开(公告)日：2008-01-17
申请号：US11835791
申请日：2007-08-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395 , A61P35/00 , A61P9/10 , C07K16/22
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US07851181B2
公开(公告)日：2010-12-14
申请号：US11835791
申请日：2007-08-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： C12P21/02
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US07847068B2
公开(公告)日：2010-12-07
申请号：US11598520
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
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公开(公告)号：US08173779B2
公开(公告)日：2012-05-08
申请号：US12941617
申请日：2010-11-08
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： C12P21/08
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US07667021B2
公开(公告)日：2010-02-23
申请号：US11598618
申请日：2006-11-13
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes isolated nucleic acids encoding fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括编码针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体的分离的核酸。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US07217796B2
公开(公告)日：2007-05-15
申请号：US10443466
申请日：2003-05-22
申请人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
发明人： Yan Wang , Robert Greenberg , Leonard Presta , Jonathan A. Pachter , Judith Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Diane Feingersh
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2869 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention includes fully human, neutralizing, monoclonal antibodies against human Insulin-like Growth Factor Receptor-I (IGFR1). The antibodies are useful for treating or preventing cancer in a subject. Also included are methods of using and producing the antibodies of the invention.
摘要翻译： 本发明包括针对人胰岛素样生长因子受体-I（IGFR1）的完全人，中和的单克隆抗体。 抗体可用于治疗或预防受试者的癌症。 还包括使用和产生本发明的抗体的方法。
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公开(公告)号：US20110014117A1
公开(公告)日：2011-01-20
申请号：US12663651
申请日：2008-06-25
申请人： Yan Wang , Jonathan A. Pachter , Judith Anne Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Mary Diane Feingersh
发明人： Yan Wang , Jonathan A. Pachter , Judith Anne Hailey , Peter Brams , Denise Williams , Mohan Srinivasan , Mary Diane Feingersh
IPC分类号： A61K51/00 , C07K16/00 , A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/20 , A61P35/00 , A61P35/04 , A61K49/00 , C12N5/12 , C12P21/04 , A61K9/127
CPC分类号： C07K16/2863 , A61K47/6803 , A61K47/6849 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： The present invention relates in part to anti-IGF1R antibodies and antigen-binding compositions thereof along with methods of use thereof. For example, methods of treating medical disorders such as cancer are covered.
摘要翻译： 本发明部分地涉及抗IGF1R抗体及其抗原结合组合物及其使用方法。 例如，涵盖治疗诸如癌症的医学病症的方法。
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公开(公告)号：US20050136063A1
公开(公告)日：2005-06-23
申请号：US10993395
申请日：2004-11-19
申请人： Yan Wang , Jonathan Pachter , Walter Bishop
发明人： Yan Wang , Jonathan Pachter , Walter Bishop
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2863 , A61K39/39541 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/565 , A61K2300/00
摘要： The present invention provides combinations including a binding composition, such as an anti-IGFR1 antibody, in association with a chemotherapeutic agent. Methods for using the combinations to treat medical conditions, such as cancer, are also provided.
摘要翻译： 本发明提供了包括与化疗剂相关的结合组合物，例如抗IGFR1抗体的组合。 还提供了使用组合治疗诸如癌症等医疗状况的方法。
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