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    Fluorescence biopsy specimen imager and methods
    11.
    发明授权
    Fluorescence biopsy specimen imager and methods 有权

    公开(公告)号：US10254227B2

    公开(公告)日：2019-04-09

    申请号：US15352427

    申请日：2016-11-15

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang

    IPC: H04N7/18 ,  G01N21/64 ,  G06T17/20 ,  G06T7/00 ,  H04N5/225 ,  G06T7/55 ,  G02B21/36 ,  G06T11/60 ,  G06T15/20 ,  H04N5/33 ,  G01N21/17

    Abstract: Biopsy imaging devices with an imaging stage configured to rotate and tilt a biological sample, as well as a method for using it, are described. The stage can use rotating bearings or extendible, telescoping arms. The device has a white light for taking normal pictures and a near-infrared laser light for causing a fluorescence-biomolecule probed sample to fluoresce for fluorescence images in a light-tight housing. A set of both types of pictures are taken from angles around, above, and below the biopsy sample with one or more cameras to generate a 3-D model in a computer of the biopsy with fluorescence markings. The 3-D model can then be rendered and viewed on a display by a surgeon to determine if sufficient margins were removed from the patient.

    Top-Down and Rotational Side View Biopsy Specimen Imager and Methods
    12.
    发明申请
    Top-Down and Rotational Side View Biopsy Specimen Imager and Methods 审中-公开

    公开(公告)号：US20180306720A1

    公开(公告)日：2018-10-25

    申请号：US15955567

    申请日：2018-04-17

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang ,  Lyle R. Middendorf

    IPC: G01N21/64

    CPC classification number: G01N21/6458 ,  G01N21/6428 ,  G01N2021/177 ,  G01N2021/1787 ,  G01N2021/6439 ,  G06T1/0007

    Abstract: Methods and devices are disclosed for the imaging of a biological sample with a top-down camera and a side-view camera. A biological sample is held on an imaging stage that is capable of rotation in two orthogonal axes. The top-down and side-view cameras can record a series of images of the sample using multiple imaging modalities at different rotational positions of the imaging stage. The top-down camera can be translated along its optical axis to affect the camera zoom and influence the resolution and field of view of the recorded images. Fluorescence excitation light sources can be positioned proximate to each of the top-down and side-view cameras to provide substantially uniform illumination of the sample for imaging with each camera.

    METHOD OF DETERMINING SURGICAL MARGINS USING FLUORESCENCE BIOPSY SPECIMEN IMAGER
    14.
    发明申请
    METHOD OF DETERMINING SURGICAL MARGINS USING FLUORESCENCE BIOPSY SPECIMEN IMAGER 审中-公开

    公开(公告)号：US20190353595A1

    公开(公告)日：2019-11-21

    申请号：US16529463

    申请日：2019-08-01

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang

    IPC: G01N21/64 ,  G02B27/22 ,  H04N5/225 ,  G06T7/55 ,  G06F3/0484 ,  G06F3/0485 ,  G02B21/16 ,  G06F3/0488

    Abstract: Methods for determining surgical margins using an imaging device are described that use multiple cameras to image a biological sample on a turntable bathed in white light or fluorescing due to a systemically administered dye. Fluorescence farther away from an excitation light source can be compensated upon determining a 3-D position of portions of the sample. The turntable is turned and tilted in order to take enough images to prepare an animation of the sample. In a graphical user interface, the animation can be stopped, zoomed, and tilted per a user's gesture, touch, tablet-tilting, or other commands. The image manipulation can be with touch gestures entered using a sterilizable or disposable touch pen.

    COMPLEMENTARY COLOR FLASHING FOR MULTICHANNEL IMAGE PRESENTATION
    15.
    发明申请
    COMPLEMENTARY COLOR FLASHING FOR MULTICHANNEL IMAGE PRESENTATION 审中-公开

    公开(公告)号：US20190209013A1

    公开(公告)日：2019-07-11

    申请号：US16359852

    申请日：2019-03-20

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang

    IPC: A61B5/00 ,  A61B1/06 ,  G06T11/00 ,  A61B1/04

    CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0073 ,  A61B6/032 ,  A61B6/5247 ,  G01N1/30 ,  G06K2209/05 ,  G06T11/00 ,  G06T11/001 ,  G06T2207/30004 ,  G06T2210/41

    Abstract: Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

    Complementary color flashing for multichannel image presentation
    16.
    发明授权
    Complementary color flashing for multichannel image presentation 有权

    公开(公告)号：US10278586B2

    公开(公告)日：2019-05-07

    申请号：US15630776

    申请日：2017-06-22

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang

    IPC: G02B21/36 ,  A61B5/00 ,  A61B1/04 ,  A61B1/06 ,  G06T11/00 ,  A61B6/03 ,  A61B6/00 ,  G01N1/30

    Abstract: Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

    Complementary Color Flashing for Multichannel Image Presentation
    17.
    发明申请
    Complementary Color Flashing for Multichannel Image Presentation 审中-公开

    公开(公告)号：US20170367582A1

    公开(公告)日：2017-12-28

    申请号：US15630776

    申请日：2017-06-22

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang

    IPC: A61B5/00 ,  A61B1/06 ,  A61B1/04 ,  A61B6/00 ,  A61B6/03 ,  G01N1/30

    CPC classification number: A61B5/0071 ,  A61B1/043 ,  A61B1/0646 ,  A61B5/0073 ,  A61B6/032 ,  A61B6/5247 ,  G01N1/30 ,  G06K2209/05 ,  G06T11/00 ,  G06T11/001 ,  G06T2207/30004 ,  G06T2210/41

    Abstract: Methods are provided for the highlighting of features in composite images through the alternating of images having complementary colors. An image having a feature of interest is used to generate one or more pseudo color images. A series of a pseudo color images and one or more additional pseudo color or original color images are then alternately displayed so that the differently colored regions among the series of images are easily recognizable to an operator. The differently colored regions differ in having hues that are complementary to one another. The methods are particularly useful for the display of information using two or more imaging modalities and channels, such as is the case for some medical applications in which a natural-light image of pink or light-red tissue with deeper red or blue vasculature is overlaid with another functional image. In these cases, a feature present in the functional image can be more easily perceived when displayed in a composite overlay with an underlying image from another imaging modality or channel.

    SIMULTANEOUS TOP-DOWN AND ROTATIONAL SIDE-VIEW FLUORESCENCE IMAGER FOR EXCISED TISSUE
    19.
    发明申请
    SIMULTANEOUS TOP-DOWN AND ROTATIONAL SIDE-VIEW FLUORESCENCE IMAGER FOR EXCISED TISSUE 有权

    公开(公告)号：US20210341389A1

    公开(公告)日：2021-11-04

    申请号：US16865044

    申请日：2020-05-01

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang ,  Lyle R. Middendorf

    IPC: G01N21/64

    Abstract: An imager for simultaneously taking full color pictures and fluorescence images from the same perspectives, top-down and side views, is presented that uses multiple cameras looking at the same stage through a beamsplitter and light sources for each view. The imager is configured to work with a particular fluorophore, or at least a predetermined fluorescence excitation wavelength and emission wavelength. A broadband white light source projects through a shortpass or other filter with a cut-off wavelength either lower than or between the excitation and emission wavelengths. Another shortpass or other filter is in front of a color camera with a cut-off wavelength below that of the emission wavelength, while a monochrome fluorescence camera may or may not have additional filters to bring out the fluorescence. These filters may be built into a dichroic mirror of the beamsplitter. In addition, digital processing may boost frequencies in the color image that were dampened by the filters.

    Motion-Adaptive Interactive Imaging
    20.
    发明申请
    Motion-Adaptive Interactive Imaging 有权

    公开(公告)号：US20210219843A1

    公开(公告)日：2021-07-22

    申请号：US17213235

    申请日：2021-03-26

    Applicant: LI-COR, Inc.

    Inventor： Han-Wei Wang ,  Lyle R. Middendorf

    IPC: A61B5/00 ,  H04N5/232 ,  A61B6/00 ,  H04N5/235 ,  G06T1/00

    Abstract: Methods and systems are provided for the detecting and presenting of faint signals from a real-time interactive imager. A real-time view of a subject is controlled by a user by entering commands that move the subject or a camera used to record the real-time view. The rate of this movement is monitored, and when the rate descends below a preset value, a trigger is sent to the camera. In response to the trigger, the camera switches to a lower frame frequency for capturing the real-time view of the subject, thereby increasing the amount of light collected in each frame, and increasing the sensitivity of the camera to faint signals. The methods and systems are particularly relevant for surgical or biopsy imaging, in which both a higher frame rate preview image of a subject for 3D visualization, and a higher sensitivity fluorescence image of the subject for tumor margin assessment, are desired.

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