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    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
    11.
    发明授权
    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 失效
    光栅传感器结合无标签结合检测和荧光放大和传感器读出系统

    公开(公告)号：US07790406B2

    公开(公告)日：2010-09-07

    申请号：US11818742

    申请日：2007-06-15

    申请人： Brian T. Cunningham ,  Peter Y. Li ,  Lance G. Laing ,  Gangadhar Jogikalmath

    发明人： Brian T. Cunningham ,  Peter Y. Li ,  Lance G. Laing ,  Gangadhar Jogikalmath

    IPC分类号： G01N33/551

    CPC分类号： G01N21/6452 ,  G01N21/648 ,  G01N21/76 ,  G01N21/7743 ,  G01N33/54373 ,  G01N33/6872 ,  Y10S436/805

    摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.

    摘要翻译： 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 描述了用于生物传感器的各种应用，包括用于评估药物化合物对细胞功能的影响的基于细胞的测定。 还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。 这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。 两种不同的发光技术可以组合在相同的生物传感器芯片上。

    GRATING BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESNCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR
    13.
    发明申请
    GRATING BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESNCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
    基于光栅的传感器组合无线绑定检测和荧光灯放大和读取传感器系统

    公开(公告)号：US20100143959A1

    公开(公告)日：2010-06-10

    申请号：US12451724

    申请日：2008-06-03

    申请人： Brian T Cunningham ,  Peter Y. Li ,  Lance G. Laing ,  Gangadhar Jogikalmath ,  Brant Binder

    发明人： Brian T Cunningham ,  Peter Y. Li ,  Lance G. Laing ,  Gangadhar Jogikalmath ,  Brant Binder

    IPC分类号： C12Q1/02 ,  C12M1/34

    CPC分类号： G01N21/6452 ,  G01N21/648 ,  G01N21/76 ,  G01N21/7743 ,  G01N33/54373 ,  G01N33/6872 ,  Y10S436/805

    摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.

    摘要翻译： 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 描述了用于生物传感器的各种应用，包括用于评估药物化合物，蛋白质，肽和其他材料对细胞功能的影响的基于细胞的测定。 还描述了针对两个不同波长的发光响应进行了优化的生物传感器实施例。 这种发光反应可以通过荧光（天然的或来自附着的荧光团），磷光，化学发光或其他发光技术产生。 两种不同的发光技术可以组合在相同的生物传感器芯片上。

    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
    15.
    发明授权
    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 有权
    光栅传感器结合无标签结合检测和荧光放大和传感器读出系统

    公开(公告)号：US07960170B2

    公开(公告)日：2011-06-14

    申请号：US12387391

    申请日：2009-04-30

    申请人： Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    发明人： Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    IPC分类号： C12M1/34

    CPC分类号： G01N21/648 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/7743 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/143333

    摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

    摘要翻译： 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。 其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。 在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。 在其他实施例中，至少一个检测器采用用于收集无标记数据的光谱仪的形式和用于收集ER数据的光电倍增管。 在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor
    16.
    发明申请
    Grating-based sensor combining label-free binding detection and fluorescence amplification and readout system for sensor 审中-公开
    光栅传感器结合无标签结合检测和荧光放大和传感器读出系统

    公开(公告)号：US20100329933A1

    公开(公告)日：2010-12-30

    申请号：US12804525

    申请日：2010-07-22

    申请人： Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    发明人： Stephen C. Schulz ,  Brian T. Cunningham ,  Lance G. Laing ,  Peter Y. Li ,  Brant Binder ,  Gangadhar Jogikalmath ,  Alex Borsody

    IPC分类号： G01N21/00

    CPC分类号： G01N21/648 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/7743 ,  Y10S435/808 ,  Y10S436/805 ,  Y10T436/143333

    摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label-free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is in the form of an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.

    摘要翻译： 公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。 公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。 其他实施方案针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。 还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。 还公开了一种用于这种传感器的读出系统。 一个实施例包括优化用于收集无标记检测数据的第一光源，为采集ER荧光放大数据而优化的第二光源和至少一个检测器。 在一个实施例中，检测器是成像系统的形式，并且包括用于收集ER和无标签数据的CCD照相机。 在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。 在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

    HIGH STRENGTH PAPER
    19.
    发明申请
    HIGH STRENGTH PAPER 有权
    高强度纸

    公开(公告)号：US20120152476A1

    公开(公告)日：2012-06-21

    申请号：US13331861

    申请日：2011-12-20

    申请人： Gangadhar Jogikalmath ,  Patrick D. Kincaid ,  Lynn Reis ,  David S. Soane

    发明人： Gangadhar Jogikalmath ,  Patrick D. Kincaid ,  Lynn Reis ,  David S. Soane

    IPC分类号： D21H17/33 ,  D21H23/00 ,  D21H17/63 ,  D21H11/00 ,  D21H17/29

    CPC分类号： D21H17/455 ,  D21H17/29 ,  D21H17/375 ,  D21H17/41 ,  D21H17/42 ,  D21H17/44 ,  D21H17/56 ,  D21H21/18

    摘要： Disclosed herein are systems and methods for attaching particulate additives to a population of cellulose fibers dispersed in an aqueous solution. The cellulose fibers are treated with an activator that forms complexes with them. The particulate additive is attached to a tether that is capable of interacting with the activator, thereby forming a tether-bearing particulate additive. The tether-bearing particulate additive can be added to the activated suspension of cellulose fibers. The resulting interaction between the tether and the activator forms durable complexes that attach the particulate additive to the cellulose fibers. Using these systems and methods, useful additives like starches can be attached to cellulose fibers, imparting advantageous properties such as increased strength to paper products formed thereby. These systems and methods are particularly useful for papermaking involving virgin pulp fibers, recycled fibers, or any combination thereof.

    摘要翻译： 本文公开了用于将微粒添加剂附着到分散在水溶液中的纤维素纤维群体的系统和方法。 纤维素纤维用与它们形成复合物的活化剂处理。 颗粒状添加剂连接到能够与活化剂相互作用的系链上，从而形成带束缚的微粒添加剂。 可将带状的颗粒添加剂加入到纤维素纤维的活化悬浮液中。 所产生的系链和活化剂之间的相互作用形成将颗粒添加剂附着到纤维素纤维上的耐久复合物。 使用这些系统和方法，可以将有用的添加剂如淀粉粘附到纤维素纤维上，赋予有利的性质，例如由此形成的纸产品的强度增加。 这些系统和方法对于涉及原浆纸浆纤维，再循环纤维或其任何组合的造纸特别有用。

    Retention Systems and Methods for Papermaking
    20.
    发明申请
    Retention Systems and Methods for Papermaking 失效
    造纸保留系统和方法

    公开(公告)号：US20100263818A1

    公开(公告)日：2010-10-21

    申请号：US12761620

    申请日：2010-04-16

    申请人： Lynn Reis ,  Gangadhar Jogikalmath ,  David S. Soane

    发明人： Lynn Reis ,  Gangadhar Jogikalmath ,  David S. Soane

    IPC分类号： D21H17/35 ,  D21H21/30 ,  D21H17/33 ,  D21H17/54

    CPC分类号： D21H17/35 ,  D21H17/33 ,  D21H21/10 ,  D21H21/30 ,  D21H21/32

    摘要： Compositions and methods of producing an optically-enhanced paper-based material are disclosed. The composition can include an optical brightening agent and an additive having an aromatic portion, where the aromatic portion is associated with an optical brightening agent. The paper-based material can exhibit a higher capacity for the optical brightening agent relative to a paper-based material that lacks the additive. Techniques for increasing optical brightening agent retention in a paper-based material are also disclosed. The techniques include using an additive having an aromatic portion, where the aromatic portion associates with an optical brightening agent so that the retention of the optical brightening agent is improved.

    摘要翻译： 公开了制备光学增强的纸基材料的组合物和方法。 组合物可以包括荧光增白剂和具有芳族部分的添加剂，其中芳族部分与荧光增白剂相关联。 相对于缺乏添加剂的纸基材料，纸基材料可以显示出对于增亮剂的较高容量。 还公开了用于增加纸基材料中光学增亮剂保留的技术。 这些技术包括使用具有芳族部分的添加剂，其中芳族部分与荧光增白剂缔合，从而提高了荧光增白剂的保留性。