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11.发明申请公开(公告)号：US20080081064A1
公开(公告)日：2008-04-03
申请号：US11904925
申请日：2007-09-28
申请人： Bruce Jelle , John Wall , Aron Anderson
发明人： Bruce Jelle , John Wall , Aron Anderson
CPC分类号： A61K9/0024 , A61F2250/0068 , A61K9/0092 , A61L27/54 , A61L27/56 , A61L31/146 , A61L31/16 , A61L2300/45
摘要： An implantable medical device for the release of bioactive agents at desired rates is described. The device includes a body member with two or more aperture sets and an inner space. The bioactive agents are arranged within the inner space of the body member so that each bioactive agent present in the inner space is individually releasable through their respective aperture set. The aperture sets modulate the release of the bioactive agents from the body member. Arrangement of apertures and bioactive agents within the inner portion chosen to provide desired and independent release rates from the device.
摘要翻译： 描述了用于以所需速率释放生物活性剂的可植入医疗装置。 该装置包括具有两个或更多孔径组件和内部空间的本体构件。 生物活性剂布置在主体构件的内部空间内，使得存在于内部空间中的每个生物活性剂可以通过它们各自的孔组件单独地释放。 孔径组调节生物活性剂从身体成分的释放。 内部部分中的孔和生物活性剂的布置被选择以从装置提供期望的和独立的释放速率。
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公开(公告)号：US20080038354A1
公开(公告)日：2008-02-14
申请号：US11824340
申请日：2007-06-28
申请人： Joram Slager , Aron Anderson
发明人： Joram Slager , Aron Anderson
IPC分类号： A61K9/00 , A61K38/00 , A61K39/395
CPC分类号： A61L27/48 , A61L27/54 , A61L31/129 , A61L31/16 , A61L2300/252 , A61L2300/256 , A61L2300/622 , C08L71/02 , C08L31/04 , C08L33/10
摘要： The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.
摘要翻译： 本发明涉及用于控制释放亲水生物活性剂的聚合物基质。 通常，洗脱控制基质包括具有第一聚合物和包含亲水生物活性剂的多个微粒的聚合物基质。 在一个实施方案中，基质包括包含亲水和疏水部分的聚合物。 在另一个实施方案中，微粒包括交联的亲水性聚合物。
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公开(公告)号：US20070082022A1
公开(公告)日：2007-04-12
申请号：US11539345
申请日：2006-10-06
申请人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
摘要翻译： 用于钝化生物材料表面的试剂和相关方法，所述试剂包括潜在反应性基团和双官能脂族酸（例如，脂肪酸），与间接基团组合，所述间隔基团以潜在的反应性基团与脂肪酸连接 这保留了每个组的所需功能。 一旦结合到表面，通过潜在的反应性基团，试剂以足以保持和定向白蛋白的方式（例如，浓度和取向）在体内将脂肪酸呈现给生理环境。
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公开(公告)号：US20070275027A1
公开(公告)日：2007-11-29
申请号：US11652852
申请日：2007-01-12
申请人： Jie Wen , Aron Anderson
发明人： Jie Wen , Aron Anderson
CPC分类号： A61K9/1635 , A61K9/0024 , A61K9/0051 , A61K9/1647 , A61K9/5026 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/622
摘要： Polymeric matrices including microparticles that provide sustained release of a hydrophilic bioactive agent are described. The matrices can be in the form of a coating on the surface of an implantable medical article or an in situ formed matrix. The microparticles of the matrix include a first polymer and a second polymer that modulates release of the hydrophilic bioactive agent from the matrix.
摘要翻译： 描述了包括提供亲水生物活性剂持续释放的微粒的聚合物基质。 基质可以是可植入医疗制品的表面上的涂层形式或原位形成的基质。 基质的微粒包括调节亲水生物活性剂从基质释放的第一聚合物和第二聚合物。
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公开(公告)号：US20050244453A1
公开(公告)日：2005-11-03
申请号：US11090655
申请日：2005-03-25
申请人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
发明人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
IPC分类号： A61F2/00 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
摘要翻译： 本发明提供了用于向医疗制品提供生物相容性表面的方法和组合物。 特别地，本发明提供具有肝素活性的生物相容性涂层。 在一些方面，本发明的生物相容性涂层能够释放生物活性剂。 可以使用生物稳定或可生物降解的聚合物材料和光反应性基团形成涂层。 本发明还提供了通过进行生物相容性涂料组合物的预辐射来提高含生物活性剂的涂层的质量的方法。
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公开(公告)号：US20060067968A1
公开(公告)日：2006-03-30
申请号：US11281845
申请日：2005-11-17
申请人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
发明人： Stephen Chudzik , Aron Anderson , Ralph Chappa , Timothy Kloke
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/606 , C08L33/06
摘要： A coating composition for use in coating implantable medical devices to improve their ability to release bioactive agents in vivo. The coating composition is particularly adapted for use with devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a mixture of a first polymer component such as poly(butyl methacrylate) and a second polymer component such as poly(ethylene-co-vinyl acetate).
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公开(公告)号：US20070104757A1
公开(公告)日：2007-05-10
申请号：US11539328
申请日：2006-10-06
申请人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
IPC分类号： A61F2/02
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US20060052460A1
公开(公告)日：2006-03-09
申请号：US11212930
申请日：2005-08-26
申请人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US20060216324A1
公开(公告)日：2006-09-28
申请号：US11440524
申请日：2006-05-25
申请人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
发明人： Sean Stucke , Ralph Chappa , Joseph Chinn , Aron Anderson
CPC分类号： A61L31/16 , A61L27/34 , A61L27/54 , A61L31/10 , A61L33/0011 , A61L2300/406 , A61L2300/416 , A61L2300/42 , A61L2300/608 , C08L33/10 , C08L29/04 , C08L39/06
摘要： The invention provides methods and compositions for providing biocompatible surfaces to medical articles. In particular the invention provides biocompatible coatings with heparin activity. In some aspects, the biocompatible coatings of the invention are able to release a bioactive agent. The coatings can be formed using biostable or biodegradable polymeric material and photoreactive groups. The invention also provides methods for improving the quality of bioactive agent-containing coatings by performing pre-irradiation of biocompatible coating compositions.
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公开(公告)号：US20060018948A1
公开(公告)日：2006-01-26
申请号：US11165993
申请日：2005-06-24
申请人： Patrick Guire , Kristin Taton , Jie Wen , David DeWitt , Robert Hergenrother , Aron Anderson
发明人： Patrick Guire , Kristin Taton , Jie Wen , David DeWitt , Robert Hergenrother , Aron Anderson
IPC分类号： A61F2/00
CPC分类号： A61L31/06 , A61L31/148 , C08L67/025 , C08L71/02
摘要： The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices.
摘要翻译： 本发明提供了由可生物降解材料制成的可植入管腔内医疗装置。 本发明还提供了利用这些装置的治疗方法。
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