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公开(公告)号：US20070104757A1
公开(公告)日：2007-05-10
申请号：US11539328
申请日：2006-10-06
申请人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
IPC分类号： A61F2/02
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US20060052460A1
公开(公告)日：2006-03-09
申请号：US11212930
申请日：2005-08-26
申请人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
IPC分类号： A61K31/12
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
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公开(公告)号：US20070082022A1
公开(公告)日：2007-04-12
申请号：US11539345
申请日：2006-10-06
申请人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
发明人： Patrick Guire , Aron Anderson , Richard Amos , Terrence Everson , Peter Duquette
CPC分类号： A61K31/12 , A61K31/74 , A61K47/6957 , A61L27/227 , A61L27/34 , A61L27/507 , A61L29/048 , A61L29/085 , A61L31/047 , A61L31/10 , A61L33/0011 , A61L33/0029 , A61L33/0082
摘要： A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
摘要翻译： 用于钝化生物材料表面的试剂和相关方法，所述试剂包括潜在反应性基团和双官能脂族酸（例如，脂肪酸），与间接基团组合，所述间隔基团以潜在的反应性基团与脂肪酸连接 这保留了每个组的所需功能。 一旦结合到表面，通过潜在的反应性基团，试剂以足以保持和定向白蛋白的方式（例如，浓度和取向）在体内将脂肪酸呈现给生理环境。
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公开(公告)号：US20060024350A1
公开(公告)日：2006-02-02
申请号：US11165884
申请日：2005-06-24
申请人： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
发明人： Signe Varner , Patrick Guire , Kristin Taton , Jie Wen , Nathan Beeley , Laurie Lawin , Robert Hergenrother , Ralph Chappa , Aron Anderson
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61F2210/0004 , A61L31/06 , C08L67/025
摘要： The invention provides implantable medical devices that are fabricated of biodegradable materials for delivery of bioactive agent to limited access regions of a patient's body, such as the eye. The invention further provides methods of treatment utilizing the devices.
摘要翻译： 本发明提供了由可生物降解材料制成的植入式医疗装置，用于将生物活性剂递送到患者身体如眼睛的有限进入区域。 本发明还提供了利用这些装置的治疗方法。
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公开(公告)号：US20060018948A1
公开(公告)日：2006-01-26
申请号：US11165993
申请日：2005-06-24
申请人： Patrick Guire , Kristin Taton , Jie Wen , David DeWitt , Robert Hergenrother , Aron Anderson
发明人： Patrick Guire , Kristin Taton , Jie Wen , David DeWitt , Robert Hergenrother , Aron Anderson
IPC分类号： A61F2/00
CPC分类号： A61L31/06 , A61L31/148 , C08L67/025 , C08L71/02
摘要： The invention provides implantable intraluminal medical devices that are fabricated of biodegradable materials. The invention further provides methods of treatment utilizing the devices.
摘要翻译： 本发明提供了由可生物降解材料制成的可植入管腔内医疗装置。 本发明还提供了利用这些装置的治疗方法。
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公开(公告)号：US20070003707A1
公开(公告)日：2007-01-04
申请号：US11423503
申请日：2006-06-12
申请人： Patrick Guire , Kristin Taton , Jie Wen
发明人： Patrick Guire , Kristin Taton , Jie Wen
IPC分类号： C08F2/48 , C07D239/02
CPC分类号： C07D251/30 , C07C275/10 , C07D251/34 , C09D139/08
摘要： The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
摘要翻译： 本发明描述了包含可光活化部分的新型交联化合物。 公开了几种化合物家族，其可以包括一种或多种有助于将化合物溶解在水性环境中的亲水部分。
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公开(公告)号：US5258041A
公开(公告)日：1993-11-02
申请号：US671621
申请日：1991-03-19
申请人： Patrick Guire , Shawn G. Dunkirk
发明人： Patrick Guire , Shawn G. Dunkirk
IPC分类号： A61F2/00 , A61K47/48 , A61L27/34 , A61L27/36 , A61L33/00 , C12N5/00 , C12N11/06 , G01N33/531 , G01N33/543 , A61F2/54
CPC分类号： A61L27/34 , A61F2/0077 , A61K47/48369 , A61L27/36 , A61L33/0011 , A61L33/0029 , C12N11/06 , C12N5/0068 , G01N33/531 , G01N33/543 , C12N2533/30 , C12N2533/54 , C12N2533/70 , C12N2533/78 , C12N2533/80 , Y10S623/901 , Y10S623/92
摘要： A method for attaching a biomolecule to a support having a hydrophobic surface, involving the use of a long chain chemical spacer having a hydrophobic guiding group capable of becoming embedded in the surface, and the biomolecule being covalently bound to the spacer at its opposite end.
摘要翻译： 一种用于将生物分子附着到具有疏水性表面的载体上的方法，涉及使用具有能够嵌入表面的疏水性引导基团的长链化学间隔物，并且生物分子在其相对端共价结合到间隔物。
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8.发明授权公开(公告)号：US08691983B2
公开(公告)日：2014-04-08
申请号：US12714911
申请日：2010-03-01
申请人： Jie Wen , Laurie R. Lawin , Patrick Guire
发明人： Jie Wen , Laurie R. Lawin , Patrick Guire
IPC分类号： A01N43/66 , A61K31/53 , C07D251/00
CPC分类号： A61L29/085 , A61F2/30767 , A61F2/3094 , A61F2002/30673 , A61L27/00 , A61L27/34 , A61L27/50 , A61L31/10 , A61L2430/24 , C09D4/00 , Y10T428/31855 , Y10T428/31935
摘要： The invention provides compositions that include crosslinking agents having multiple photoactivatable groups, such as diaryl ketones, or a diaryl ketone, such as benzophenone, and at least one polymerizable monomer, such as a zwitterionic monomer. The compositions are useful as surface coating agents that provide brush type polymeric coatings. These polymeric coatings can be used on medical devices, such as artificial joints, to reduce wear and tear between the components of the joint and thus reduce or eliminate debris generated by friction between the joint components.
摘要翻译： 本发明提供了包括具有多个可光活化基团的交联剂的组合物，例如二芳基酮或二芳基酮，例如二苯甲酮，和至少一种可聚合单体，例如两性离子单体。 该组合物可用作提供刷式聚合物涂层的表面涂层剂。 这些聚合物涂层可用于诸如人造关节的医疗装置上，以减少接头部件之间的磨损和撕裂，从而减少或消除由接头部件之间的摩擦产生的碎屑。
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公开(公告)号：US07989619B2
公开(公告)日：2011-08-02
申请号：US11457170
申请日：2006-07-13
申请人： Patrick Guire , Kristin Taton , Jie Wen , Laurie R. Lawin
发明人： Patrick Guire , Kristin Taton , Jie Wen , Laurie R. Lawin
IPC分类号： C07D251/32 , C07D251/34 , C08K5/3492 , C09K11/06
CPC分类号： C09D7/1233 , C08K5/0025 , C09D7/63 , Y10T428/31507 , Y10T428/31511 , Y10T428/31551 , Y10T428/31678 , Y10T428/31721 , Y10T428/31725 , Y10T428/31855 , Y10T428/31989 , Y10T428/31993
摘要： The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.
摘要翻译： 本发明描述了包含交联化合物，聚合物和任选具有氧化物层的1nm至约25微米尺寸的颗粒的新型组合物。 特别地，颗粒是二氧化硅和已经用硅烷预处理的颗粒。
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10.发明授权公开(公告)号：US07772393B2
公开(公告)日：2010-08-10
申请号：US11423503
申请日：2006-06-12
申请人： Patrick Guire , Kristin Taton , Jie Wen
发明人： Patrick Guire , Kristin Taton , Jie Wen
IPC分类号： C07D251/32 , C07D251/34 , C08K5/3492 , C09K11/06
CPC分类号： C07D251/30 , C07C275/10 , C07D251/34 , C09D139/08
摘要： The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
摘要翻译： 本发明描述了包含可光活化部分的新型交联化合物。 公开了几种化合物家族，其可以包括一种或多种有助于将化合物溶解在水性环境中的亲水部分。
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