公开(公告)号：US20050053588A1

公开(公告)日：2005-03-10

申请号：US10493536

申请日：2002-10-18

申请人： Li Yin

发明人： Li Yin

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61L27/00 ,  A61P3/10 ,  C12N5/02 ,  C12N5/071 ,  C12N5/10 ,  C12P21/00 ,  A61K48/00 ,  C12N5/08

CPC分类号： C12N5/0676 ,  A61K35/12 ,  C12N2500/25 ,  C12N2500/36 ,  C12N2500/38 ,  C12N2501/105 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/12 ,  C12N2501/13 ,  C12N2501/148 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2501/165 ,  C12N2501/24 ,  C12N2501/335 ,  C12N2501/345 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/998 ,  C12N2506/03 ,  C12N2506/14 ,  C12N2510/00 ,  C12N2510/02

摘要： The subject invention a method for converting liver stem/progenitor cells to a pancreatic functional cell by transfecting said liver cells with a pancreatic development gene and/or by culturing with pancreatic differentiation factors. The resulting cells produce and secrete insulin protein in response to glucose stimulation.

摘要翻译： 本发明公开了通过用胰腺发育基因转染所述肝细胞和/或通过用胰分化因子培养来将肝脏/祖细胞转化为胰腺功能细胞的方法。 所得细胞响应葡萄糖刺激产生和分泌胰岛素蛋白。

公开(公告)号：US08326669B2

公开(公告)日：2012-12-04

申请号：US11737249

申请日：2007-04-19

申请人： Madhukar R. Korupolu ,  Sandeep M. Uttamchandani ,  Kaladhar Voruganti ,  Li Yin

发明人： Madhukar R. Korupolu ,  Sandeep M. Uttamchandani ,  Kaladhar Voruganti ,  Li Yin

IPC分类号： G06F9/44

CPC分类号： G06Q10/06312 ,  G06F11/0793 ,  G06Q10/06 ,  G06Q10/06316 ,  G06Q10/0635

摘要： Disclosed is a storage management framework that integrates corrective action plans output from multiple different types of planning tools, sorts the different corrective action plans based on utility and risk values and outputs a time-based schedule for implementing one or more of the corrective action plans to resolve identified current and anticipated workload service level objective (SLO) violations.

摘要翻译： 公开了一种存储管理框架，其将来自多种不同类型的规划工具的校正行动计划的输出整合在一起，根据效用和风险值对不同的纠正行动计划进行排序，并输出基于时间的时间表，以执行一个或多个纠正措施计划 解决当前和预期的工作负载服务级别目标（SLO）违规。

公开(公告)号：US07640231B2

公开(公告)日：2009-12-29

申请号：US11280012

申请日：2005-11-16

申请人： Guillermo A. Alvarez ,  John D. Palmer ,  Sandeep M. Uttamchandani ,  Li Yin

发明人： Guillermo A. Alvarez ,  John D. Palmer ,  Sandeep M. Uttamchandani ,  Li Yin

IPC分类号： G06F7/00

CPC分类号： G06F9/50 ,  G06F9/5083 ,  Y10S707/99932

摘要： A technique of allocating shared resources in a computer network-based storage system comprises taking periodic performance samples on a running storage system; evaluating an objective function that takes as input the performance samples to quantify how aligned a current state of the storage system is with organizational objectives; building and maintaining models of behavior and capabilities of the storage system by using the performance samples as input; determining how resources of the storage system should be allocated among client computers in the storage system by selecting one among many possible allocations based on predictions generated by the models in order to maximize a value of the objective function; calculating a confidence statistic value for a chosen resource allocation based on an accuracy of the models; and enforcing the chosen resource allocation on the running storage system when the confidence statistic value is at or above a predetermined threshold value.

摘要翻译： 在基于计算机网络的存储系统中分配共享资源的技术包括在正在运行的存储系统上采取周期性的性能样本; 评估一个目标函数，作为输入性能样本，以量化存储系统的当前状态与组织目标的一致性; 通过使用性能样本作为输入，建立和维护存储系统的行为和功能模型; 通过基于由模型生成的预测来选择许多可能的分配中的一个，以便最大化目标函数的值来确定应该在存储系统中的客户端计算机之间分配存储系统的资源; 基于模型的精度计算所选资源分配的置信度统计值; 以及当所述置信度统计值处于或高于预定阈值时，在所述运行存储系统上执行所选择的资源分配。

公开(公告)号：US07552152B2

公开(公告)日：2009-06-23

申请号：US11681971

申请日：2007-03-05

申请人： Elizabeth S. Richards ,  Sandeep M. Uttamchandani ,  Li Yin

发明人： Elizabeth S. Richards ,  Sandeep M. Uttamchandani ,  Li Yin

IPC分类号： G06F12/00

CPC分类号： G06F3/0653 ,  G06F3/0605 ,  G06F3/0647 ,  G06F3/0683 ,  Y10S707/99953 ,  Y10S707/99955

摘要： The embodiments of the invention provide a method, computer program product, etc. for risk-modulated proactive data migration for maximizing utility. More specifically, a method of planning data migration for maximizing utility of a storage infrastructure that is running and actively serving at least one application includes selecting a plurality of potential data items for migration and selecting a plurality of potential migration destinations to which the potential data items can be moved. Moreover, the method selects a plurality of potential migration speeds at which the potential data items can be moved and selects a plurality of potential migration times at which the potential data items can be moved to the potential data migration destinations. The selecting of the plurality of potential migration speeds selects a migration speed below a threshold speed, wherein the threshold speed defines a maximum system utility loss permitted.

摘要翻译： 本发明的实施例提供了一种用于风险调节的主动数据迁移的方法，计算机程序产品等，以最大化效用。 更具体地说，一种规划数据迁移以最大化正在运行并主动地为至少一个应用服务的存储基础设施的效用的方法包括：选择多个潜在数据项以进行迁移并选择多个潜在迁移目的地，潜在数据项 可以移动 此外，该方法选择可移动潜在数据项的多个潜在迁移速度，并选择潜在数据项能够移动到潜在数据迁移目的地的多个潜在迁移时间。 选择多个潜在迁移速度选择低于阈值速度的迁移速度，其中阈值速度定义允许的最大系统效用损失。

公开(公告)号：US20080222644A1

公开(公告)日：2008-09-11

申请号：US12061764

申请日：2008-04-03

申请人： Elizabeth S. Richards ,  Sandeep M. Uttamchandani ,  Li Yin

发明人： Elizabeth S. Richards ,  Sandeep M. Uttamchandani ,  Li Yin

IPC分类号： G06F9/50 ,  G06F12/00

CPC分类号： G06F3/0653 ,  G06F3/0605 ,  G06F3/0647 ,  G06F3/0683 ,  Y10S707/99953 ,  Y10S707/99955

摘要： The embodiments of the invention provide a method, computer program product, etc. for risk-modulated proactive data migration for maximizing utility. More specifically, a method of planning data migration for maximizing utility of a storage infrastructure that is running and actively serving at least one application includes selecting a plurality of potential data items for migration and selecting a plurality of potential migration destinations to which the potential data items can be moved. Moreover, the method selects a plurality of potential migration speeds at which the potential data items can be moved and selects a plurality of potential migration times at which the potential data items can be moved to the potential data migration destinations. The selecting of the plurality of potential migration speeds selects a migration speed below a threshold speed, wherein the threshold speed defines a maximum system utility loss permitted.

摘要翻译： 本发明的实施例提供了一种用于风险调节的主动数据迁移的方法，计算机程序产品等，以最大化效用。 更具体地说，一种规划数据迁移以最大化正在运行并主动地为至少一个应用服务的存储基础设施的效用的方法包括：选择多个潜在数据项以进行迁移并选择多个潜在迁移目的地，潜在数据项 可以移动 此外，该方法选择可移动潜在数据项的多个潜在迁移速度，并选择潜在数据项能够移动到潜在数据迁移目的地的多个潜在迁移时间。 选择多个潜在迁移速度选择低于阈值速度的迁移速度，其中阈值速度定义允许的最大系统效用损失。

公开(公告)号：US20070112723A1

公开(公告)日：2007-05-17

申请号：US11280012

申请日：2005-11-16

申请人： Guillermo Alvarez ,  John Palmer ,  Sandeep Uttamchandani ,  Li Yin

发明人： Guillermo Alvarez ,  John Palmer ,  Sandeep Uttamchandani ,  Li Yin

IPC分类号： G06F17/30

CPC分类号： G06F9/50 ,  G06F9/5083 ,  Y10S707/99932

摘要： A technique of allocating shared resources in a computer network-based storage system comprises taking periodic performance samples on a running storage system; evaluating an objective function that takes as input the performance samples to quantify how aligned a current state of the storage system is with organizational objectives; building and maintaining models of behavior and capabilities of the storage system by using the performance samples as input; determining how resources of the storage system should be allocated among client computers in the storage system by selecting one among many possible allocations based on predictions generated by the models in order to maximize a value of the objective function; calculating a confidence statistic value for a chosen resource allocation based on an accuracy of the models; and enforcing the chosen resource allocation on the running storage system when the confidence statistic value is at or above a predetermined threshold value.

摘要翻译： 在基于计算机网络的存储系统中分配共享资源的技术包括在正在运行的存储系统上采取周期性的性能样本; 评估一个目标函数，作为输入性能样本，以量化存储系统的当前状态与组织目标的一致性; 通过使用性能样本作为输入，建立和维护存储系统的行为和功能模型; 通过基于由模型生成的预测来选择许多可能的分配中的一个，以便最大化目标函数的值来确定应该在存储系统中的客户端计算机之间分配存储系统的资源; 基于模型的精度计算所选资源分配的置信度统计值; 以及当所述置信度统计值处于或高于预定阈值时，在所述运行存储系统上执行所选择的资源分配。