-
公开(公告)号：US20120046350A1
公开(公告)日：2012-02-23
申请号：US12689014
申请日：2010-01-18
IPC分类号： A61K31/381 , A61P3/04 , A61P3/10 , A61P3/08 , A61K31/192 , A61K31/341
CPC分类号： C07D307/38 , C07C323/20 , C07D333/18 , C07D333/54 , C07D409/14
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARδ超型。
-
公开(公告)号：US20050080115A1
公开(公告)日：2005-04-14
申请号：US10692561
申请日：2003-10-24
IPC分类号： C07C323/20 , C07D307/38 , C07D333/18 , C07D333/54 , C07D409/14 , A61K31/44 , A61K31/235 , A61K31/325 , A61K31/40
CPC分类号： C07D307/38 , C07C323/20 , C07D333/18 , C07D333/54 , C07D409/14
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
-
公开(公告)号：US07709528B2
公开(公告)日：2010-05-04
申请号：US11439827
申请日：2006-05-23
CPC分类号： C07D307/38 , C07C323/20 , C07D333/18 , C07D333/54 , C07D409/14
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARδ超型。
-
公开(公告)号：US06274608B1
公开(公告)日：2001-08-14
申请号：US09551700
申请日：2000-04-18
IPC分类号： A61K31426
CPC分类号： C07D277/20 , C07D277/34
摘要： Disclosed are novel compounds of formula I wherein R1, R2, R3, L, X and Y are as defined in the specification. These compounds are useful in the treatment of conditions mediated by nuclear receptors, in particular the Retinoid X Receptor (RXR) and the Peroxisome Proliferator-Activated Receptor (PPAR) families. Such conditions include diabetes and obesity.
摘要翻译： 公开了式I的新化合物，其中R1，R2，R3，L，X和Y如说明书中所定义。 这些化合物可用于治疗由核受体介导的病症，特别是视黄醇X受体（RXR）和过氧化物酶体增殖物激活受体（PPAR）家族。 这些病症包括糖尿病和肥胖。
-
公开(公告)号：US20060287393A1
公开(公告)日：2006-12-21
申请号：US11439827
申请日：2006-05-23
IPC分类号： A61K31/195 , C07C311/27
CPC分类号： C07D307/38 , C07C323/20 , C07D333/18 , C07D333/54 , C07D409/14
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
-
公开(公告)号：US06972294B1
公开(公告)日：2005-12-06
申请号：US09551740
申请日：2000-04-18
IPC分类号： A61K31/44 , C07C59/68 , C07C69/734 , C07D213/02 , C07D213/30 , C07D307/42 , C07D333/16
CPC分类号： C07D213/30 , C07C59/68 , C07C69/734 , C07D307/42 , C07D333/16
摘要： Disclosed are novel compounds of formula (I) wherein A1, A2, Ar, R5, R6, R8, M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). Such conditions include diabetes and obesity.
摘要翻译： 公开了式（I）的新化合物，其中A 1，A 2，Ar，R 5，R 6， >，R 8，M，Q，Y，Z，k，m和n如说明书中所定义。 这些化合物可用于治疗和/或预防由核受体介导的病症，特别是过氧化物酶体增殖物激活受体（PPAR）。 这些病症包括糖尿病和肥胖。
-
公开(公告)号：US20050070583A1
公开(公告)日：2005-03-31
申请号：US10693161
申请日：2003-10-24
申请人： Lone Jeppesen , John Mogensen , Ingrid Pettersson , Per Sauerberg , Pavel Pihera , Miroslav Havranek
发明人： Lone Jeppesen , John Mogensen , Ingrid Pettersson , Per Sauerberg , Pavel Pihera , Miroslav Havranek
IPC分类号： C07C59/68 , C07C69/712 , C07C323/20 , A61K31/445 , A61K31/325 , A61K31/40
CPC分类号： C07C323/20 , C07C59/68 , C07C69/712
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPARδ suptype.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体增殖物激活受体（PPAR）介导的病症，特别是PPARdelta suptype。
-
公开(公告)号：US07943613B2
公开(公告)日：2011-05-17
申请号：US12097564
申请日：2006-12-21
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： C07D295/155 , A61K31/5375
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，可用于治疗由其介导的病症。
-
公开(公告)号：US08362016B2
公开(公告)日：2013-01-29
申请号：US13079460
申请日：2011-04-04
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： A61K31/5375 , C07D295/155
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，应用于治疗由其介导的病症。
-
公开(公告)号：US20110245244A1
公开(公告)日：2011-10-06
申请号：US13079460
申请日：2011-04-04
申请人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
发明人： Per Sauerberg , Pavel Pihera , Zdenek Polivka , Miroslav Havranek , Ingrid Pettersson , John Patrick Mogensen
IPC分类号： A61K31/5377 , C07D413/12 , C07D333/60 , A61K31/381 , C07D265/30 , A61K31/5375 , C07D211/62 , A61K31/445 , C07C59/68 , A61K31/192 , C07D213/55 , A61K31/4402 , C07D231/12 , A61K31/415 , C07D241/04 , A61K31/495 , C07D207/04 , A61K31/40 , C07D405/10 , A61K31/4025 , A61P3/10
CPC分类号： A61K31/5377 , A61K31/192 , A61K31/195 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/415 , A61K31/4402 , A61K31/445 , A61K31/495 , A61K31/5375 , C07C59/70 , C07C217/48 , C07C323/16 , C07C323/32 , C07C2601/02 , C07D211/46 , C07D213/30 , C07D213/36 , C07D231/12 , C07D265/30 , C07D295/096 , C07D295/112 , C07D307/79 , C07D307/81 , C07D333/16 , C07D333/20 , C07D333/54
摘要： Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARδ and should be useful for treating conditions mediated by the same.
摘要翻译： 通式（I）的新型化合物，这些化合物作为药物组合物的用途，包含该化合物的药物组合物和使用这些化合物和组合物的治疗方法。 本发明化合物是PPARδ的活化剂，应用于治疗由其介导的病症。
-
-
-
-
-
-
-
-
-
搜索结果
93 条记录 (耗时 0.038 秒)
