公开(公告)号：US20170073771A1

公开(公告)日：2017-03-16

申请号：US15278697

申请日：2016-09-28

Applicant: EXACT SCIENCES CORPORATION ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/68

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

Abstract translation: 本发明涉及用于确定和使用指示腺瘤和癌症的特异性甲基化模式的方法和组合物。 特别地，本发明涉及在来自癌症和腺瘤样品的DNA中配位甲基化的定义的CpG基因座的分析，用于鉴定配位甲基化位点的方法以及在设计中的一个或多个标记区域中使用配位甲基化位点分析的方法 腺瘤和癌症检测。

公开(公告)号：US20160090634A1

公开(公告)日：2016-03-31

申请号：US14864158

申请日：2015-09-24

Applicant: Mayo Foundation for Medical Education and Research

Inventor： John B. Kisiel ,  David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarinoma.

Abstract translation: 本文提供了涉及检测瘤形成的技术，特别是但不排他地涉及用于检测诸如胆管癌的肿瘤的方法，组合物和相关用途。

公开(公告)号：US20140221252A1

公开(公告)日：2014-08-07

申请号：US14168552

申请日：2014-01-30

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

Abstract translation: 本文件涉及检测恶变前期和恶性肿瘤的方法和材料。 例如，提供了用于确定来自哺乳动物的粪便样品是否含有肿瘤的核酸标记物或多肽标记物的方法和材料。

公开(公告)号：US12188093B2

公开(公告)日：2025-01-07

申请号：US17120518

申请日：2020-12-14

Applicant: Mayo Foundation for Medical Education and Research

Inventor： John B. Kisiel ,  David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarcinoma.

公开(公告)号：US20240352534A1

公开(公告)日：2024-10-24

申请号：US18644335

申请日：2024-04-24

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

公开(公告)号：US12043871B2

公开(公告)日：2024-07-23

申请号：US18062419

申请日：2022-12-06

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US20240191308A1

公开(公告)日：2024-06-13

申请号：US18508945

申请日：2023-11-14

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

公开(公告)号：US11987847B2

公开(公告)日：2024-05-21

申请号：US17120500

申请日：2020-12-14

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

公开(公告)号：US20240052425A1

公开(公告)日：2024-02-15

申请号：US18279980

申请日：2022-03-04

Applicant: Mayo Foundation for Medical Education and Research

Inventor： William R. Taylor ,  Dougias W. Mahoney ,  John B. Kisiel ,  David A. Ahlquist

IPC: C12Q1/6886 ,  C12Q1/6851

CPC classification number: C12Q1/6886 ,  C12Q1/6851 ,  C12Q2600/154 ,  C12Q1/6806

Abstract: Provided herein is technology for cervical cancer screening. In particular, provided herein are methods, compositions, and related uses for detecting the presence or absence of cervical cancer, cervical pre-cancers (e.g., cervix related in-situ adenocarcinoma, cervical intraepithelial neoplasia), and cervical cancer subtypes (e.g., cervical adenocarcinoma, squamous cell cervical cancer), or for discriminating cervical cancer from other types of gynecological cancers (e.g., endometrial, and ovarian cancers) from a biological sample (e.g., a tissue sample (e.g., cervical tissue), a blood sample, a plasma sample, a serum sample, a whole blood sample, a secretion sample (e.g., cervical secretion, vaginal secretion), an organ secretion sample, a CSF sample, a saliva sample, a urine sample, or a stool sample).

公开(公告)号：US20230416840A1

公开(公告)日：2023-12-28

申请号：US18323031

申请日：2023-05-24

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Brian A. Dukek ,  Matthew T. Gettman ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology for prostate cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of prostate cancer.