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公开(公告)号：US20150247720A1
公开(公告)日：2015-09-03
申请号：US14715182
申请日：2015-05-18
申请人： Medlumics S.L.
CPC分类号： G01B9/02091 , A61B5/0066 , G01B9/02049 , G02B6/06 , G02B6/1221 , G02B6/13 , G02B6/136 , G02B6/262 , G02B6/32 , G02B6/3596
摘要： A system and method for depth-resolved imaging of a sample are presented. The system for depth-resolved imaging of a sample includes a substrate of substantially flexible material, a plurality of waveguides disposed on the substrate, an optical element disposed at a distal end of the plurality of waveguides, and one or more interferometers. Light is collected from the sample through the optical element and plurality of waveguides on the flexible substrate on its path to the one or more interferometers. The interferometers are configured to combine a reference light with the light received by at least a portion of the plurality of waveguides to resolve contributions from one or more depths of the sample. The system further includes a light guiding element coupled between the plurality of waveguides and the one or more interferometers.
摘要翻译： 提出了一种用于样本深度分辨成像的系统和方法。 用于样品的深度分辨成像的系统包括基本上柔性材料的衬底，设置在衬底上的多个波导，设置在多个波导的远端的光学元件以及一个或多个干涉仪。 通过光学元件和柔性基板上的多个波导在其通向一个或多个干涉仪的路径上从样本收集光。 干涉仪被配置为将参考光与由多个波导的至少一部分接收的光结合以解决来自样本的一个或多个深度的贡献。 该系统还包括耦合在多个波导与一个或多个干涉仪之间的导光元件。
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公开(公告)号：US09062960B2
公开(公告)日：2015-06-23
申请号：US13761054
申请日：2013-02-06
申请人： Medlumics S.L.
CPC分类号： G01B9/02091 , A61B5/0066 , G01B9/02049 , G02B6/06 , G02B6/1221 , G02B6/13 , G02B6/136 , G02B6/262 , G02B6/32 , G02B6/3596
摘要： A system and method for depth-resolved imaging of a sample are presented. The system for depth-resolved imaging of a sample includes a substrate of substantially flexible material, a plurality of waveguides disposed on the substrate, an optical element disposed at a distal end of the plurality of waveguides, and one or more interferometers. Light is collected from the sample through the optical element and plurality of waveguides on the flexible substrate on its path to the one or more interferometers. The interferometers are configured to combine a reference light with the light received by at least a portion of the plurality of waveguides to resolve contributions from one or more depths of the sample. The system further includes a light guiding element coupled between the plurality of waveguides and the one or more interferometers.
摘要翻译： 提出了一种用于样本深度分辨成像的系统和方法。 用于样品的深度分辨成像的系统包括基本上柔性材料的衬底，设置在衬底上的多个波导，设置在多个波导的远端的光学元件以及一个或多个干涉仪。 通过光学元件和柔性基板上的多个波导在其通向一个或多个干涉仪的路径上从样本收集光。 干涉仪被配置为将参考光与由多个波导的至少一部分接收的光结合以解决来自样本的一个或多个深度的贡献。 该系统还包括耦合在多个波导与一个或多个干涉仪之间的导光元件。
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13.发明申请Diagnostic Device for Dermatology with Merged OCT and Epiluminescence Dermoscopy 审中-公开用于合并OCT和发光皮肤镜的皮肤病诊断装置公开(公告)号：US20150133778A1
公开(公告)日：2015-05-14
申请号：US14530054
申请日：2014-10-31
申请人： Medlumics S.L.
CPC分类号： A61B5/444 , A61B5/0013 , A61B5/0017 , A61B5/0022 , A61B5/0035 , A61B5/0066 , A61B5/0077 , A61B5/7246 , A61B5/7425 , A61B2576/02 , G01B9/02091 , G16H40/67
摘要： Systems and methods for use of the imaging system are presented. In an embodiment, the imaging system includes a first optical path, a second optical path, a plurality of optical elements, a detector, and a processor. The first optical path guides a first beam of radiation associated with epiluminescence while the second optical path guides a second beam of radiation associated with optical coherence tomography. The plurality of optical elements transmit the first and second beams of radiation onto a sample. The detector generates optical data associated with the first and second beams of radiation returning from the sample. The optical data associated with the first and second beams of radiation correspond to substantially non-coplanar regions of the sample. The processor correlates the optical data of the first beam with the optical data of the second beam and generates an image of the sample.
摘要翻译： 介绍了使用成像系统的系统和方法。 在一个实施例中，成像系统包括第一光路，第二光路，多个光学元件，检测器和处理器。 第一光路引导与外发光相关联的第一辐射束，而第二光路引导与光学相干断层摄影相关联的第二辐射束。 多个光学元件将第一和第二辐射束发射到样品上。 检测器产生与从样品返回的第一和第二辐射束相关联的光学数据。 与第一和第二辐射束相关联的光学数据对应于样品的基本非共面区域。 处理器将第一光束的光学数据与第二光束的光学数据相关联，并生成样本的图像。
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公开(公告)号：US20190175023A1
公开(公告)日：2019-06-13
申请号：US16277863
申请日：2019-02-15
申请人： Medlumics S.L.
发明人： Eduardo Margallo Balbás , Alejandro Barriga Rivera , José Luis Rubio Guivernau , Santiago Jiménez Valero , Juan Lloret Soler
摘要： Embodiments for crossing an occlusion by controlling a guide with the aid of optical coherence tomography (OCT) data are described. Embodiments include transmitting one or more beams of radiation via one or more waveguides on a flexible substrate within a guide wire. One or more beams of scattered or reflected radiation may be received from a sample via one or more waveguides. Depth-resolved optical data of the sample may be generated based on the received beams of scattered or reflected radiation. The depth-resolved data may be used for determining at least one of a distance between the guide wire and a wall of the artery and a distance between the guide wire and an occlusion within the artery. A position of the guide wire within the artery may then be controlled based on the determined distance or distances.
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公开(公告)号：US10194981B2
公开(公告)日：2019-02-05
申请号：US15220186
申请日：2016-07-26
申请人： MEDLUMICS S.L.
发明人： Eduardo Margallo Balbás , José Luis Rubio Guivernau , Santiago Jiménez Valero , Alejandro Barriga Rivera , Justo Contreras Bermejo , Juan Lloret Soler , Juan Sancho Durá
摘要： Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes several interconnected optical ports configured to transmit exposure radiation toward a sample and receive radiation that have been reflected or scattered from the sample. The interconnected optical ports are formed on a substrate having rigid sections and flexible sections arranged around the distal section. A holder maintains the interconnected optical elements in a fixed spatial relationship.
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公开(公告)号：US20150209105A1
公开(公告)日：2015-07-30
申请号：US14608026
申请日：2015-01-28
申请人： MEDLUMICS S.L.
发明人： Eduardo Margallo Balbás , José Luis Rubio Guivernau , Santiago Jiménez Valero , Alejandro Barriga Rivera , Justo Contreras Bermejo , Juan Lloret Soler
CPC分类号： A61B18/1492 , A61B5/0066 , A61B5/0084 , A61B5/01 , A61B5/0538 , A61B5/4836 , A61B5/4848 , A61B5/6852 , A61B5/6885 , A61B5/6886 , A61B5/742 , A61B18/24 , A61B2017/00057 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00636 , A61B2018/00785 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/00982 , A61B2034/104 , A61B2090/064 , A61B2505/05 , A61B2562/0242 , A61B2576/023
摘要： Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.
摘要翻译： 描述了在使用低相干干涉测量（LCI）数据监测过程时执行RF消融的系统和方法。 导管包括远端部分，近端部分，多路复用器和耦合在远侧部分和近端部分之间的鞘。 远端部分包括被配置为将RF能量施加到与电极接触的部分样品的一个或多个电极。 远侧部分还包括多个光学元件，其被配置为将一个或多个曝光辐射束从导管的远端部分远离。 近端部分包括配置成产生辐射源的光源和配置成产生深度分辨的光学数据的检测器。 多路复用器被配置为产生来自源辐射束的一个或多个曝光辐射束。
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公开(公告)号：US11517199B2
公开(公告)日：2022-12-06
申请号：US16277863
申请日：2019-02-15
申请人： Medlumics S.L.
发明人： Eduardo Margallo Balbás , Alejandro Barriga Rivera , José Luis Rubio Guivernau , Santiago Jiménez Valero , Juan Lloret Soler
IPC分类号： A61B5/00 , A61B17/00 , A61B5/02 , A61M25/09 , A61B1/00 , A61B1/07 , A61B18/18 , A61B17/22 , A61B18/00
摘要： Embodiments for crossing an occlusion by controlling a guide with the aid of optical coherence tomography (OCT) data are described. Embodiments include transmitting one or more beams of radiation via one or more waveguides on a flexible substrate within a guide wire. One or more beams of scattered or reflected radiation may be received from a sample via one or more waveguides. Depth-resolved optical data of the sample may be generated based on the received beams of scattered or reflected radiation. The depth-resolved data may be used for determining at least one of a distance between the guide wire and a wall of the artery and a distance between the guide wire and an occlusion within the artery. A position of the guide wire within the artery may then be controlled based on the determined distance or distances.
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公开(公告)号：US20210077181A1
公开(公告)日：2021-03-18
申请号：US16950499
申请日：2020-11-17
申请人： MEDLUMICS S.L.
发明人： Eduardo Margallo Balbás , José Luis Rubio Guivernau , Santiago Jiménez Valero , Alejandro Barriga Rivera , Justo Contreras Bermejo , Juan Lloret Soler
摘要： Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.
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公开(公告)号：US10206584B2
公开(公告)日：2019-02-19
申请号：US14820255
申请日：2015-08-06
申请人： Medlumics S.L.
发明人： Eduardo Margallo Balbás , Alejandro Barriga Rivera , José Luis Rubio Guivernau , Santiago Jiménez Valero , Juan Lloret Soler
IPC分类号： A61B5/00 , A61B5/02 , A61M25/09 , A61B1/00 , A61B1/07 , A61B18/18 , A61B17/00 , A61B17/22 , A61B18/00
摘要： Systems and methods for controlling a guide with the aid of optical coherence tomography (OCT) data are described. A guide wire includes at least one optical fiber, a flexible substrate, and one or more optical elements. The at least one optical fiber transmits a source beam of radiation. The flexible substrate includes a plurality of waveguides. At least one of the plurality of waveguides transmits one or more beams of radiation away from the guide wire, and at least one of the plurality of waveguides receives one or more beams of scattered radiation that have been reflected or scattered from a sample. The multiplexer generates the one or more beams of exposure radiation from the source beam of radiation. The one or more optical elements at least one of focus and steer the one or more beams of radiation.
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公开(公告)号：US09739940B2
公开(公告)日：2017-08-22
申请号：US15065126
申请日：2016-03-09
申请人： Medlumics S.L.
CPC分类号： G02B6/122 , G02B6/12 , G02B6/12004 , G02B6/124 , G02B6/2861 , G02B6/29331 , G02B6/29332 , G02B6/29344 , G02B6/29352 , G02B2006/12104 , G02B2006/12142 , G02B2006/12147 , H01S5/1028
摘要： A photonic integrated circuit is presented that includes a substrate, and a first and second waveguide patterned on the substrate. The first waveguide guides an input beam of radiation. The photonic integrated circuit also includes a coupling region, wherein the first and second waveguides each pass through the coupling region. One or more modulating elements are coupled to each of the first and second waveguides. The first waveguide and the second waveguide have a first facet and a second facet, respectively, and first and second reflections are generated at the first and second facets within the first and second waveguides, respectively. The one or more modulating elements coupled to each of the first and second waveguides are designed to adjust the phase of the first and second reflections before the first and second reflections pass through the coupling region.
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