公开(公告)号：US20180009754A1

公开(公告)日：2018-01-11

申请号：US15544837

申请日：2016-01-20

Applicant: MERIAL, INC.

Inventor： Alan Long ,  Dpuglas Edward Wilkinson

IPC: C07D213/74 ,  A61K45/06 ,  A61K31/496

CPC classification number: C07D213/74 ,  A61K31/496 ,  A61K45/06 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D487/04

Abstract: The present invention relates to novel anthelmintic compounds of formula (IA) below: wherein, Y is selected from the group consisting of —H, aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, alkyl, haloalkyl, and alkoxyalkyl; and Z is selected from the group consisting of aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocyclyl, alkyl, haloalkyl, and alkoxyalkyl. Variables Ring A, Ring B, Ring C, X1, X6, and X8 are as defined herein. The invention also relates to parasiticidal compositions comprising the compounds, and methods and uses of the compounds for treating and preventing parasitic infections and infestations in animals.

公开(公告)号：US20170233438A1

公开(公告)日：2017-08-17

申请号：US15378219

申请日：2016-12-14

Applicant: MERIAL INC.

Inventor： Loic Le Hir de Fallois ,  Greg Pacofsky ,  Alan Long ,  Charles Q. Meng ,  Hyoung Ik Lee

IPC: C07K11/02 ,  A61K45/06 ,  A61K38/15

CPC classification number: C07K11/02 ,  A01N43/72 ,  A61K38/15 ,  A61K45/06 ,  C07D273/00 ,  C07D413/14

Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.

公开(公告)号：US20170022253A1

公开(公告)日：2017-01-26

申请号：US15160577

申请日：2016-05-20

Applicant: MERIAL INC.

Inventor： Loic Le Hir de Fallois ,  Greg Pacofsky ,  Alan Long ,  Charles Meng ,  Hyoung Ik Lee ,  Cyprian O. Ogbu

IPC: C07K11/02

CPC classification number: C07K11/02 ,  A01N43/72 ,  A61K38/00 ,  C07D273/00 ,  A01N37/46 ,  A01N43/90

Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

Abstract translation: 本发明提供式（I）的环状缩肽化合物和包含有效对抗伤害动物的寄生虫的化合物的组合物。 化合物和组合物可用于对抗哺乳动物和鸟类中或哺乳动物上的寄生虫。 本发明还提供了用于消除，控制和预防鸟类和哺乳动物中的寄生虫感染的改进方法。

公开(公告)号：US10433552B2

公开(公告)日：2019-10-08

申请号：US15480316

申请日：2017-04-05

Applicant: MERIAL INC.

Inventor： Chunhua Yang ,  Loic Patrick Le Hir de Fallois ,  Charles Q. Meng ,  Alan Long ,  Roelof Johannes Gorter de Vries ,  Bruno Baillon ,  Sylvaine Lafont ,  Myriam Gay de Saint Michel ,  Stephane Kozlovic

IPC: C07D453/04 ,  A01N43/80 ,  C07D261/04 ,  A01N43/42 ,  A61K31/42

Abstract: This invention relates to processes for the preparation of antiparasitic isoxazoline compounds enriched in an enantiomer using quinine-based chiral phase transfer catalyst. The invention also relates to novel quinine-based phase transfer catalysts and to a toluene solvent form of the isoxazoline compound of the invention.

公开(公告)号：US10155725B2

公开(公告)日：2018-12-18

申请号：US14981847

申请日：2015-12-28

Applicant: MERIAL, INC.

Inventor： Charles Q. Meng ,  Alan Long ,  Scot Huber ,  Srinivas Reddy Gurrala ,  Douglas Edward Wilkinson ,  Gregory Pacofsky

IPC: A61K31/497 ,  C07D215/38 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07D241/04 ,  C07D277/64 ,  C07D307/81 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D471/08 ,  C07D403/12 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D333/66 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D263/58 ,  C07D277/82 ,  C07D295/15 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/82 ,  C07C233/56 ,  C07C235/16 ,  A61K31/47 ,  A61K31/472 ,  C07D211/58 ,  C07D295/16 ,  C07D333/60

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.