公开(公告)号：US12151995B2

公开(公告)日：2024-11-26

申请号：US18467190

申请日：2023-09-14

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise ,  Ellalahewage Sathyajith Kumarasinghe

IPC: C07C229/12 ,  A61K9/00 ,  A61K9/127 ,  A61K9/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  A61K38/18 ,  A61K47/54 ,  A61K47/69 ,  A61K48/00 ,  C07C227/16 ,  C07C227/18 ,  C07C229/16 ,  C07C233/36 ,  C07C233/72 ,  C07C235/10 ,  C07C255/24 ,  C07C263/20 ,  C07C271/20 ,  C07C275/14 ,  C07C279/12 ,  C07C279/24 ,  C07C279/28 ,  C07C279/32 ,  C07C311/05 ,  C07C335/08 ,  C07D207/27 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D277/38 ,  C07F9/09 ,  C07K14/505

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US11969506B2

公开(公告)日：2024-04-30

申请号：US16493814

申请日：2018-03-15

Applicant: ModernaTX, Inc. ,  Oregon State University

Inventor： Siddharth Patel ,  Emily Robinson ,  Anna Brown ,  Orn Almarsson ,  Kerry E. Benenato ,  Staci Sabnis ,  Gaurav Sahay ,  Ashwani Kumar Narayana

IPC: A61K9/51 ,  A61K31/7088 ,  A61K45/06 ,  A61K48/00 ,  C12N15/113

CPC classification number: A61K9/5123 ,  A61K9/5146 ,  A61K31/7088 ,  A61K45/06 ,  A61K48/0033 ,  C12N15/113 ,  C12N2320/32

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include an ionizable lipid, a phospholipid, a first sterol or a tocopherol, and optionally a second sterol different from the first sterol. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US11597698B2

公开(公告)日：2023-03-07

申请号：US17324426

申请日：2021-05-19

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise ,  Edward Hennessy ,  Ellalahewage S. Kumarasinghe

IPC: C07C229/12 ,  A61K47/00 ,  A61K9/00 ,  C07C229/24 ,  A61K47/54 ,  A61K9/127 ,  A61K31/713 ,  A61K48/00

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US10857105B2

公开(公告)日：2020-12-08

申请号：US16382423

申请日：2019-04-12

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Ellalahewage Sathyajith Kumarasinghe ,  Mark Cornebise

IPC: A61K9/127 ,  A61K31/00 ,  A61K9/51 ,  A61K38/18 ,  A61K48/00 ,  C07C229/24

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US10442756B2

公开(公告)日：2019-10-15

申请号：US15846084

申请日：2017-12-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise

IPC: C07C229/12 ,  A61K9/127 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C233/72 ,  C07C263/20 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K9/16 ,  A61K38/18 ,  A61K48/00 ,  C07K14/505 ,  A61K9/00 ,  A61K47/54 ,  A61K47/69 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US09868691B2

公开(公告)日：2018-01-16

申请号：US15476253

申请日：2017-03-31

Applicant: MODERNATX, Inc.

Inventor： Kerry E. Benenato

IPC: A61K9/51 ,  A61K48/00 ,  C07C229/12 ,  A61K9/127 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K9/16 ,  A61K38/18 ,  C07K14/505 ,  A61K9/00 ,  A61K47/54 ,  A61K47/69

CPC classification number: C07C229/12 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0073 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/5123 ,  A61K9/5146 ,  A61K31/7105 ,  A61K38/1725 ,  A61K38/1816 ,  A61K47/543 ,  A61K47/6911 ,  A61K48/00 ,  A61K48/0033 ,  A61K48/005 ,  C07C227/16 ,  C07C227/18 ,  C07C229/16 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07C271/20 ,  C07C275/14 ,  C07C279/12 ,  C07C279/24 ,  C07C279/28 ,  C07C279/32 ,  C07C311/05 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07D207/27 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D277/38 ,  C07F9/091 ,  C07K14/505

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US12263248B2

公开(公告)日：2025-04-01

申请号：US17278040

申请日：2019-09-19

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise ,  Edward Hennessy

IPC: A61K9/127 ,  A61K31/167 ,  A61K31/519 ,  A61K31/573 ,  A61K31/7105 ,  A61K45/06 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  C07C215/08 ,  C07C229/12 ,  C07C229/14 ,  C07C229/16 ,  C07C233/47 ,  C07C235/10 ,  C07C275/14 ,  C07C279/28 ,  C07C279/36 ,  C07C311/05 ,  C07C311/14 ,  C07C311/64 ,  C07C335/08 ,  C07D209/48 ,  C07D233/61 ,  C07D239/47 ,  C07D239/54 ,  C07D249/04 ,  C07D295/13 ,  C07D473/18 ,  C07D473/34 ,  C07F9/09 ,  A61K48/00

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US11220476B2

公开(公告)日：2022-01-11

申请号：US16555045

申请日：2019-08-29

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise

IPC: C07C229/12 ,  C07C271/20 ,  C07C279/12 ,  C07C279/28 ,  C07C279/32 ,  C07D233/72 ,  C07D249/04 ,  C07D263/20 ,  C07D265/33 ,  C07D271/06 ,  C07D271/10 ,  C07D207/27 ,  C07D277/38 ,  C07C275/14 ,  C07C279/24 ,  C07C311/05 ,  C07C229/16 ,  C07C335/08 ,  C07C233/36 ,  C07C235/10 ,  C07C255/24 ,  C07F9/09 ,  A61K47/54 ,  A61K47/69 ,  A61K9/00 ,  A61K9/127 ,  C07C233/72 ,  C07C263/20 ,  A61K9/16 ,  A61K38/18 ,  A61K48/00 ,  C07K14/505 ,  C07C227/16 ,  A61K9/51 ,  A61K31/7105 ,  A61K38/17 ,  C07C227/18

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US11066355B2

公开(公告)日：2021-07-20

申请号：US17025779

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  Mark Cornebise ,  Edward Hennessy ,  Ellalahewage S. Kumarasinghe

IPC: C07C229/00 ,  A61K47/00 ,  A61K9/00 ,  C07C229/24 ,  A61K48/00 ,  A61K31/713 ,  A61K9/127 ,  A61K47/54

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US10195156B2

公开(公告)日：2019-02-05

申请号：US16004850

申请日：2018-06-11

Applicant: ModernaTX, Inc.

Inventor： Kerry E. Benenato ,  William Butcher

IPC: A61K9/51 ,  C07D295/185 ,  A61K38/18

Abstract: The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.