公开(公告)号：US20070155513A1

公开(公告)日：2007-07-05

申请号：US11716577

申请日：2007-03-12

Applicant: Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

Inventor： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

IPC: F16D7/02 ,  F16F15/121

CPC classification number: F16F15/129

Abstract: A torque fluctuation absorbing device includes a first rotational member which transmits a torque from a driving power source, a damping mechanism connected with an input shaft of a transmission, the damping mechanism having a pair of frictional members of approximately annular-shaped fixed at both surfaces of a disc, and a limiter portion for frictionally engaging the pair of frictional members with the first rotational member in a substantially direct manner or in a substantially indirect manner via a pair of frictional plates. An actual length of at least one of the pair of frictional members ranges substantially between 1 percent and 6 percent of a major diameter of the at least one of the pair of frictional members.

Abstract translation: 扭矩波动吸收装置包括：传递来自驱动动力源的转矩的第一旋转构件，与变速器的输入轴连接的阻尼机构，所述阻尼机构具有在两面固定的大致环状的一对摩擦构件 以及限制器部分，用于通过一对摩擦板以基本上直接的方式或以基本上间接的方式摩擦地与所述第一旋转部件摩擦接合所述一对摩擦部件。 一对摩擦构件中的至少一个的实际长度基本上在一对摩擦构件中的至少一个的大直径的1％至6％之间。

公开(公告)号：US07176219B2

公开(公告)日：2007-02-13

申请号：US11128238

申请日：2005-05-13

Applicant: Masahiko Hayakawa ,  Kiyohiro Samizu ,  Hiroshi Uebayashi ,  Ken Ikeda ,  Makoto Takeuchi

Inventor： Masahiko Hayakawa ,  Kiyohiro Samizu ,  Hiroshi Uebayashi ,  Ken Ikeda ,  Makoto Takeuchi

IPC: A61K31/44

CPC classification number: C07D453/02

Abstract: There is provided an acid addition salt of (−)-(3R)-quinuclidin-3-yl(1R)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate with an acid selected from the group consisting of (−)-(2S,3S)-tartaric acid, (+)-(2S,3S)-di-O-benzoyltartaric acid, (+)-(2S,3S)-di-O-(4-methylbenzoyl)tartaric acid, (−)-L-phenylalanine, benzenesulfonic acid, cyclohexanesulfamic acid, hydrobromic acid, naphthalene-2-sulfonic acid, sebacic acid, (+)-camphor-10-sulfonic acid, p-toluenesulfonic acid, ethanesulfonic acid, methanesulfonic acid and methyl phosphate, which has little hygroscopicity that affects the use as a drug or its drug substance, and is very useful as a drug or its drug substance.

Abstract translation: 提供了（ - ） - （3R） - 奎宁环-3-基（1R）-1-苯基-1,2,3,4-四氢异喹啉-2-羧酸的酸加成盐，其中酸选自 的（ - ） - （2S，3S） - 酒石酸，（+） - （2S，3S） - 二-O-苯甲酰基酒石酸，（+） - （2S，3S） - 二-O-（4-甲基苯甲酰基） 酒石酸，（ - ） - L-苯丙氨酸，苯磺酸，环己烷氨基磺酸，氢溴酸，萘-2-磺酸，癸二酸，（+） - 樟脑-10-磺酸，对甲苯磺酸，乙磺酸，甲磺酸 酸和磷酸甲酯，其吸湿性几乎不影响作为药物或其药物物质的用途，并且作为药物或其药物物质是非常有用的。

公开(公告)号：US20050096322A1

公开(公告)日：2005-05-05

申请号：US10505939

申请日：2003-02-27

Applicant: Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

Inventor： Susumu Igarashi ,  Ryo Naito ,  Yoshinori Okamoto ,  Noriyuki Kawano ,  Issei Tsukamoto ,  Ippei Sato ,  Makoto Takeuchi ,  Hiroyuki Kanoh ,  Masato Kobori

IPC: A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  A61P43/00 ,  C07D487/04 ,  A61K31/503

CPC classification number: C07D487/04

Abstract: As a result of an effort made by us for the purpose of developing a therapeutic agent having a bone formation-stimulating effect by promoting the functions of osteoblasts, the present inventors discovered that a certain nitrogen-containing heterocyclic compound exhibits a potent bone formation-stimulating effect on the osteoblast and thus can serve as an excellent prophylactic or therapeutic agent against a metabolic bone disease, whereby establishing the present invention. Thus, the present invention provides a 3,6-disubstituted 1,2,4-triazolo[4,3-b]pyridazine compound or a pharmaceutically acceptable salt thereof as well as a pharmaceutical composition comprising such a compound and a pharmaceutically acceptable carrier, especially a bone-forming agent.

Abstract translation: 本发明人为了通过促进成骨细胞的功能开发具有促进骨形成刺激作用的治疗剂而作出努力的结果，发现某些含氮杂环化合物表现出强有力的骨形成刺激 对成骨细胞的作用，因此可以作为抗代谢性骨病的优异的预防或治疗剂，由此建立本发明。 因此，本发明提供了3,6-二取代的1,2,4-三唑并[4,3-b]哒嗪化合物或其药学上可接受的盐，以及包含这种化合物和药学上可接受的载体的药物组合物， 特别是骨形成剂。

公开(公告)号：US20050067249A1

公开(公告)日：2005-03-31

申请号：US10950657

申请日：2004-09-28

Applicant: Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

Inventor： Satoshi Nakagaito ,  Masaru Ebata ,  Makoto Takeuchi ,  Hiroshi Ichikawa

IPC: F16F15/139 ,  F16D7/02 ,  F16F15/129 ,  F16H35/10

CPC classification number: F16F15/129

Abstract: A torque fluctuation absorbing device includes a first rotational member transmitted with a torque from a driving power source, a damping mechanism connected with an input shaft of a transmission, the damping mechanism having a pair of frictional members of approximately annular-shaped fixed at both surfaces of a disc, and a limiter portion for frictionally engaging the pair of frictional members with the first rotational member in a substantially direct manner or in a substantially indirect manner via a pair of frictional plates. An actual length of at least one of the pair of frictional members ranges substantially between 1 percent and 6 percents of a major diameter of the at least one of the pair of frictional members.

Abstract translation: 一种扭矩波动吸收装置，包括以驱动动力源的转矩传递的第一旋转构件，与变速器的输入轴连接的减震机构，该阻尼机构具有在两面固定的大致环状的一对摩擦构件 以及限制器部分，用于通过一对摩擦板以基本上直接的方式或以基本上间接的方式摩擦地与所述第一旋转部件摩擦接合所述一对摩擦部件。 一对摩擦构件中的至少一个的实际长度基本上在一对摩擦构件中的至少一个的大直径的1％至6％之间。

公开(公告)号：US06815191B1

公开(公告)日：2004-11-09

申请号：US09700993

申请日：2001-07-20

Applicant: Kazuo Kobayashi ,  Makoto Takeuchi ,  Akihiko Iwamatsu ,  Kenji Yamamoto ,  Hidehiko Kumagai ,  Satoshi Yoshida

Inventor： Kazuo Kobayashi ,  Makoto Takeuchi ,  Akihiko Iwamatsu ,  Kenji Yamamoto ,  Hidehiko Kumagai ,  Satoshi Yoshida

IPC: C12N926

CPC classification number: C12Y302/01096 ,  C12N9/2402

Abstract: An endo-&bgr;-N-acetylglucosaminidase gene encoding the following protein (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 3; and (b) a protein comprising an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 3 by deletion, substitution, or addition of at least one amino acid and having the activity of endo-&bgr;-N-acetylglucosaminidase.

公开(公告)号：US06552992B2

公开(公告)日：2003-04-22

申请号：US09793165

申请日：2001-02-26

Applicant: Makoto Takeuchi ,  Kazuhiko Kitamura

Inventor： Makoto Takeuchi ,  Kazuhiko Kitamura

IPC: G11B1920

CPC classification number: F16F15/363 ,  G01M1/36 ,  G11B19/2009 ,  G11B19/2027 ,  G11B25/043

Abstract: A weight member is attached to a rotor so as to forcibly offset a center of gravity of a rotor from a rotating axis, centrifugal force moves two movable weight members to appropriate positions for canceling the unbalance due to the center of gravity offset from the rotating axis, and stoppers restrict the movement of the two movable weight members in a sectoral area opposite to the center of gravity so that the rotor is free from vibrations due to the characteristic angular velocity.

Abstract translation: 配重部件被安装在转子上，从而将转子的重心从旋转轴线上强制地偏移，离心力将两个可动配重件移动到合适的位置，以消除由于重心偏离旋转轴线的不平衡 并且止动件限制两个可移动重量件在与重心相反的扇形区域中的移动，使得转子由于特征角速度而没有振动。

公开(公告)号：US06338955B2

公开(公告)日：2002-01-15

申请号：US09117860

申请日：1998-08-12

Applicant: Suguru Oguri ,  Mari Minowa ,  Aruto Yoshida ,  Naoyuki Taniguchi ,  Makoto Takeuchi

Inventor： Suguru Oguri ,  Mari Minowa ,  Aruto Yoshida ,  Naoyuki Taniguchi ,  Makoto Takeuchi

IPC: C12N1554

CPC classification number: C12N9/1051

Abstract: The present invention relates to a novel enzyme having &bgr;1→4 N-acetylglucosaminyltransferase (GnT-IV) activity; a gene encoding the enzyme; a recombinant DNA comprising the gene; a host cell comprising the recombinant DNA; a method for producing an enzyme protein having GnT-IV activity comprising culturing the host cell in a medium; and a saccharide in which the sugar chain is modified using a GnT-IV. According to the present invention, a novel GnT-IV, a method for producing the enzyme and a gene coding for the enzyme are provided. With the GnT-IV of the present invention, it has become possible to produce a saccharide having a branching structure which could not be formed with conventional glycosyltransferases. Thus, the GnT-IV of the invention is useful not only for producing or improving glycoconjugate type pharmaceuticals, reagents and foods, but also for modifying the sugar chain structure of any biopolymer.

Abstract translation: 本发明涉及具有β1-4N-乙酰葡糖胺基转移酶（GnT-IV）活性的新型酶; 编码酶的基因; 包含该基因的重组DNA; 包含重组DNA的宿主细胞; 制备具有GnT-IV活性的酶蛋白质的方法，包括在培养基中培养宿主细胞; 以及使用GnT-IV对糖链进行修饰的糖类。根据本发明，提供新的GnT-IV，该酶的制造方法和编码该酶的基因。 利用本发明的GnT-IV，可以制备具有不能用常规糖基转移酶形成的支化结构的糖类。 因此，本发明的GnT-IV不仅可用于生产或改进糖缀合物型药物，试剂和食品，而且用于改变任何生物聚合物的糖链结构。

公开(公告)号：US06334764B1

公开(公告)日：2002-01-01

申请号：US09588776

申请日：2000-06-07

Applicant: Hiroyuki Kobayashi ,  Makoto Takeuchi ,  Takahide Itoh ,  Tetsuzou Ukai

Inventor： Hiroyuki Kobayashi ,  Makoto Takeuchi ,  Takahide Itoh ,  Tetsuzou Ukai

IPC: F04C1800

CPC classification number: F04C29/0021 ,  F04C27/005 ,  Y10S418/01

Abstract: A scroll compressor having a simple structure is disclosed, which effectively decreases the thrust load imposed on the revolving scroll without degrading the compression efficiency. The scroll compressor includes a casing; a fixed scroll provided in the housing and comprising an end plate and a spiral protrusion built on one face of the end plate; and a revolving scroll provided in the casing and comprising an end plate and a spiral protrusion built on one face of the end plate, wherein the spiral protrusions of each scroll are engaged with each other so as to form a spiral compression chamber. In the above structure, an introduced working gas is compressed in the compression chamber and then discharged according to the revolution of the revolving scroll; a thrust member for thrust-supporting the end plate of the revolving scroll is provided at the back-face side of the end plate of the revolving scroll; a pressure pocket is formed in a face of one of the thrust member and the end plate of the revolving scroll, wherein the face faces the other of the thrust member and the end plate of the revolving scroll; and a high-pressure introduction hole for introducing a high-pressure fluid into the pressure pocket is provided at one of the thrust member side and the revolving scroll side.

Abstract translation: 公开了一种具有简单结构的涡旋压缩机，其有效地降低了施加在旋转涡卷上的推力负荷而不降低压缩效率。 涡旋压缩机包括壳体; 设置在所述壳体中的固定涡卷，包括端板和构成在所述端板的一个面上的螺旋突起; 以及旋转涡卷，其设置在所述壳体中并且包括端板和构成在所述端板的一个面上的螺旋突起，其中每个涡旋盘的螺旋形突起彼此接合以形成螺旋压缩室。 在上述结构中，引入的工作气体在压缩室中被压缩，然后根据回转涡卷的旋转而排出; 在回转涡卷的端板的背面设置有用于推力支撑回转涡卷的端板的推力构件， 在旋转涡旋件的推力构件和端板中的一个的表面上形成有压力袋，其中面朝向旋转涡卷的止推构件和端板中的另一个; 并且在推力构件侧和回转涡卷一侧设置有用于将高压流体引入压力槽的高压引入孔。

公开(公告)号：US06331102B1

公开(公告)日：2001-12-18

申请号：US09600865

申请日：2000-08-09

Applicant: Makoto Takeuchi ,  Kou Tanaka

Inventor： Makoto Takeuchi ,  Kou Tanaka

IPC: F01C102

CPC classification number: F01C17/063

Abstract: A mechanism preventing rotation is mainly composed of plural swivel pins (31) projectingly provided on an end plate of a swiveling scroll (15), housing pins (32) which is the same number as the swivel pins (31) on a front end plate (11b) provided onto the end plate, and a pin engaging member (33) having plural holes (34) in which these pins (31) and (32) respectively. These holes (34) are formed sufficiently larger diameter than the swivel pin (31) and the housing pin (32). According to this mechanism preventing rotation, while the swiveling scroll (15) performs a revolution swivel movement, these pins (31) and (32) and the inner surface of the pin engaging member (33) controls radial maximum variation with sliding-contacting each other. Accordingly, fluid leak that occurs by an engaging position error of a stationary scroll and the swiveling scroll is effectively prevented and long service life and improvement of degree of freedom of designs are actualized.

Abstract translation: 防止旋转的机构主要由突出设置在旋转涡旋件（15）的端板上的多个旋转销（31）构成，在前端板上具有与旋转销（31）相同数量的壳体销（32） （11b），以及分别具有这些销（31）和（32）的多个孔（34）的销接合构件（33）。 这些孔（34）形成为比旋转销（31）和壳体销（32）足够大的直径。 根据这种防止旋转的机构，当旋转涡旋件（15）进行旋转旋转运动时，这些销（31）和（32）和销接合构件（33）的内表面控制径向最大变化，每个滑动接触 其他。 因此，有效地防止了由固定涡旋件和旋转涡旋件的接合位置误差而发生的流体泄漏，从而实现了长期使用寿命和设计自由度的提高。

公开(公告)号：US06310762B1

公开(公告)日：2001-10-30

申请号：US09261625

申请日：1999-03-03

Applicant: Michio Okamura ,  Makoto Takeuchi

Inventor： Michio Okamura ,  Makoto Takeuchi

IPC: H01G9155

CPC classification number: H01G9/155 ,  Y02E60/13

Abstract: There is disclosed a carbon material from which an electric double layer capacitor (EDLC) having a large capacitance can be fabricated. First, a carbon material is activated to produce crystallites of graphite-like carbon having interlayer distances of 0.365 to 0.385 nm. Positive and negative plates are fabricated using the crystallites.

Abstract translation: 公开了可以制造具有大电容的双电层电容器（EDLC）的碳材料。 首先，碳材料被活化以产生层间距离为0.365至0.385nm的石墨状碳的微晶。 使用微晶制造正极和负极板。