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16 条记录 (耗时 0.039 秒)

    Indole derivatives which inhibit steroid 5.alpha. reductase
    14.
    发明授权
    Indole derivatives which inhibit steroid 5.alpha. reductase 失效
    抑制甾体5（ALPHA）还原的吲哚衍生物

    公开(公告)号：US5239083A

    公开(公告)日：1993-08-24

    申请号：US850334

    申请日：1992-03-10

    申请人： Toshiaki Kumazawa ,  Hitoshi Takami ,  Hiroyuki Obase ,  Nobuyuki Kishibayashi ,  Akio Ishii

    发明人： Toshiaki Kumazawa ,  Hitoshi Takami ,  Hiroyuki Obase ,  Nobuyuki Kishibayashi ,  Akio Ishii

    IPC分类号： C07D209/08 ,  C07D401/06

    CPC分类号： C07D401/06 ,  C07D209/08

    摘要： The present invention provides Indole derivatives represented by the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent hydrogen or lower alkyl;R.sup.4 represents hydrogen, lower alkyl or cycloalkyl;R.sup.5 represents hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl,--CHR.sup.7 R.sup.8 where R.sup.7 and R.sup.8 independently represent hydrogen, alkyl, alkenyl, alkynyl, substituted or unsubstituted cycloalkyl, --(CH.sub.2).sub.m OR.sup.9 (wherein m is an integer of 1-3 and R.sup.9 is lower alkyl), substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, or substituted or unsubstituted thienyl], ##STR2## (wherein Y is CH.sub.2, O, S, CH.sub.2 --CH.sub.2, CH.dbd.CH, CH.sub.2 --O or CH.sub.2 --S); R.sup.6 represents hydrogen, lower alkyl or lower alkoxy or halogen;X represents O or S(O)q (wherein q is an integer of 0-2); and n represents an integer of 1-6) or pharmaceutically acceptable salt thereof.The compound shows prominent inhibition effects on steroid 5.alpha.-reductase activity, and are useful in treating benign prostatic hypertrophy, prostate cancer, baldness and acne.

    Method of effecting immunoassay by using affinity chromatography
    15.
    发明授权
    Method of effecting immunoassay by using affinity chromatography 失效
    通过亲和层析进行免疫测定的方法

    公开(公告)号：US4937200A

    公开(公告)日：1990-06-26

    申请号：US32501

    申请日：1987-03-31

    申请人： Toshiaki Kumazawa ,  Makoto Nakamura ,  Eriko Kogure

    发明人： Toshiaki Kumazawa ,  Makoto Nakamura ,  Eriko Kogure

    IPC分类号： G01N33/50 ,  G01N33/543

    CPC分类号： G01N33/543

    摘要： A method of effecting an immunoassay using affinity chromatography which a sample is injected into a reusable column charged with antibody applied on a solid support, an eluent is injected into the column to elute antigen bound with the antibody on the solid support, and an amount of eluted antigen is measured. In order to mitigate the influence of carry-overs of successive samples, blank values are corrected such that they include the carry-overs of previously measured samples, while elution time periods are kept constant. In one embodiment, the elution time periods are corrected such that blank values for respective samples are made constant.

    摘要翻译： 使用亲和层析进行免疫测定的方法，其将样品注入装有施加在固体支持体上的抗体的可重复使用的柱中，将洗脱液注入柱中以洗脱固体支持物上与抗体结合的抗原， 测定洗脱的抗原。 为了减轻连续样品的遗留影响，校正空白值，使得它们包括先前测量的样品的残留，而洗脱时间段保持恒定。 在一个实施方案中，校正洗脱时间周期，使得各个样品的空白值保持恒定。

    Antiulcer [1] benzepino[3,4-b]pyridine and compositions
    16.
    发明授权
    Antiulcer [1] benzepino[3,4-b]pyridine and compositions 失效
    抗溃疡[1]苯并[3,4-b]吡啶和组合物

    公开(公告)号：US4547496A

    公开(公告)日：1985-10-15

    申请号：US623084

    申请日：1984-06-21

    申请人： Toshiaki Kumazawa ,  Yoshimasa Oiji ,  Hiroshi Tanaka ,  Katsuichi Shuto

    发明人： Toshiaki Kumazawa ,  Yoshimasa Oiji ,  Hiroshi Tanaka ,  Katsuichi Shuto

    IPC分类号： C07D491/04 ,  C07D491/044 ,  C07D495/04 ,  C07D519/00 ,  A61K31/44 ,  A61K31/535

    CPC分类号： C07D491/04 ,  C07D495/04

    摘要： A novel [1] benzepino[3,4-b]pyridine derivative having antiulcer activity is represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom, an alkyl group, a halogenated alkyl group, an alkoxy group or a halogen atom; R.sup.2 represents ##STR2## wherein Y represents an amino group, a substituted amino group, a heterocyclic group or a substituted heterocyclic group; Z represents a hydrogen atom, an alkyl group or an acyl group; and m is an integer of 1-3, ##STR3## wherein Z' represents a hydrogen atom or an alkyl group; Y has the same meaning as defined above, and n is 0, 1 or 2; or ##STR4## wherein Z and n have the same meanings as defined above; X represents an oxygen atom or a sulfur atom. Also disclosed are pharmaceutically acceptable acid addition salts of the compound represented by the formula (I).

    摘要翻译： 具有抗溃疡活性的新型[1]苯并[3,4-b]吡啶衍生物由式（I）表示：其中R 1表示氢原子，烷基，卤代烷基， 烷氧基或卤素原子; R2表示，其中Y表示氨基，取代氨基，杂环基或取代的杂环基; Z表示氢原子，烷基或酰基; m为1-3的整数，其中Z'表示氢原子或烷基; Y具有与上述相同的含义，n为0,1或2; 或其中Z和n具有与上述相同的含义; X表示氧原子或硫原子。 还公开了由式（I）表示的化合物的药学上可接受的酸加成盐。