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公开(公告)号：US06350600B1
公开(公告)日：2002-02-26
申请号：US09627769
申请日：2000-07-28
申请人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N900
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides trmA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recominant techniques from strepococcus pneumoniae. Also provided are methods for utilizing polypepides to screen for antibacterial compounds.
摘要翻译： 本发明提供trmA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过来自肺炎链球菌的重组技术产生此类多肽的方法。 还提供了利用多肽来筛选抗菌化合物的方法。
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公开(公告)号：US06245542B1
公开(公告)日：2001-06-12
申请号：US09306276
申请日：1999-05-06
申请人： Sanjoy Biswas , Alexander Bryant , James Raymond Brown , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Stephanie Van Horn , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Alexander Bryant , James Raymond Brown , Alison Francis Chalker , David John Holmes , Karen Anne Ingraham , Chi Young So , Stephanie Van Horn , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N910
CPC分类号： C12N9/1007 , A61K38/00
摘要： The invention provides yfjO polypeptides and polynucleotides encoding yfjO polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yfjO polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了yfjO多肽和编码yfjO多肽的多核苷酸，以及通过重组技术产生此类多肽的方法。 还提供了利用yfj多肽筛选抗菌化合物的方法。
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13.发明授权Polynucleotides encoding tRNA methyl transferases from Streptococcus pneumoniae 有权编码来自肺炎链球菌的tRNA甲基转移酶的多核苷酸
公开(公告)号：US6165764A
公开(公告)日：2000-12-26
申请号：US274825
申请日：1999-03-23
申请人： David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker
发明人： David John Holmes , Karen Anne Ingraham , Thomas B Mathie , Richard Lloyd Warren , Magdalena Zalacain , Sanjoy Biswas , James Raymond Brown , Chi Young So , Alison Francis Chalker
CPC分类号： C12N9/1007 , A61K38/00 , A61K39/00 , A61K48/00
摘要： The invention provides tRNA methyl transferase (trmD) polypeptides and polynucleotides encoding trmD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing trmD polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供tRNA甲基转移酶（trmD）多肽和编码trmD多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用trmD多肽筛选抗菌化合物的方法。
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公开(公告)号：US07202071B2
公开(公告)日：2007-04-10
申请号：US10437581
申请日：2003-05-14
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06303771B1
公开(公告)日：2001-10-16
申请号：US09080643
申请日：1998-05-18
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
IPC分类号： C12N1531
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06346395B1
公开(公告)日：2002-02-12
申请号：US09239052
申请日：1999-01-27
申请人： Alison Francis Chalker , Christine Debouck , David John Holmes , Karen Anne Ingraham , Deborah Dee Jaworski , Anna Lisa Kosmatka , Damien McDevitt , Jeffrey Mooney , Stewart C Pearson , Chi Yong So , Nicola Gail Wallis , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
发明人： Alison Francis Chalker , Christine Debouck , David John Holmes , Karen Anne Ingraham , Deborah Dee Jaworski , Anna Lisa Kosmatka , Damien McDevitt , Jeffrey Mooney , Stewart C Pearson , Chi Yong So , Nicola Gail Wallis , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
IPC分类号： C12D2106
CPC分类号： C12N9/0006 , A61K38/00 , C12Y101/011
摘要： The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了FabG多肽和编码FabG多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用FabG多肽筛选抗菌化合物的方法。
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