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公开(公告)号：US06326462B1
公开(公告)日：2001-12-04
申请号：US09491916
申请日：2000-01-27
申请人： Christine Debouck , Jason Craig Fedon , Deborah Dee Jaworski , Jeffrey Mooney , Leslie Marie Palmer , Christopher Michael Traini , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
发明人： Christine Debouck , Jason Craig Fedon , Deborah Dee Jaworski , Jeffrey Mooney , Leslie Marie Palmer , Christopher Michael Traini , Min Wang , Richard Lloyd Warren , Yi Yi Zhong
IPC分类号： A61K3902
CPC分类号： C12N9/1085 , A61K38/00
摘要： The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribH多肽和编码ribH多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribH多肽筛选抗菌化合物的方法。
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公开(公告)号：US06280971B1
公开(公告)日：2001-08-28
申请号：US09227806
申请日：1999-01-11
申请人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
发明人： Min Wang , Judith M Ward , Richard Lloyd Warren , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M Pratt , David Justin Charles Knowles , Michael Arthur Lonetto , Jeffrey Mooney , Michael Terence Black , Martin Karl Russell Burnham , Christine Debouck , Jason Craig Fedon , John Edward Hodgson , Deborah Dee Jaworski , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Yi Y Zhong
IPC分类号： C12N1231
CPC分类号： C12Y305/04025 , C07K2319/00 , C12N9/78
摘要： The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供ribA多肽和编码ribA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ribA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06270992B1
公开(公告)日：2001-08-07
申请号：US08963901
申请日：1997-11-04
申请人： Nicola Gail Wallis , Christopher Michael Traini , Anna Lisa Kosmatka , Lisa Kathleen Shilling , Richard Lloyd Warren
发明人： Nicola Gail Wallis , Christopher Michael Traini , Anna Lisa Kosmatka , Lisa Kathleen Shilling , Richard Lloyd Warren
IPC分类号： C12N500
CPC分类号： C12N9/1223 , A61K39/00 , A61K2039/51
摘要： The invention provides Histidine kinase polypeptides and polynucleotides encoding Histidine kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供组氨酸激酶多肽和编码组氨酸激酶多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用组氨酸激酶多肽筛选抗菌化合物的方法。
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公开(公告)号：US07176299B2
公开(公告)日：2007-02-13
申请号：US11166905
申请日：2005-06-23
申请人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
发明人： Michael Terence Black , Martin Karl Russell Burnham , Jason Craig Fedon , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard Oakley Nicholas , Leslie Marie Palmer , Julie M. Pratt , Raymond Winfield Reichard , Martin Rosenberg , Christopher Michael Traini , Judith M. Ward , Richard Lloyd Warren
CPC分类号： C12N9/0036 , A61K38/00 , A61K39/00 , C07K14/31 , C07K16/1275 , C07K2319/00 , C12N9/78 , C12N15/52 , C12Q1/689 , C12Q2600/158 , C12Y105/0103 , C12Y305/04025
摘要： This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
摘要翻译： 本发明涉及新鉴定的葡萄球菌多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。
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公开(公告)号：US6159949A
公开(公告)日：2000-12-12
申请号：US7476
申请日：1998-01-15
申请人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Christopher Michael Traini , Richard Warren , Min Wang
发明人： Michael Terence Black , Deborah Dee Jaworski , Anna Lisa Kosmatka , Christopher Michael Traini , Richard Warren , Min Wang
IPC分类号： C12N15/09 , A61K31/00 , A61K38/00 , A61K39/085 , A61K39/395 , A61K45/00 , A61K48/00 , A61P31/00 , C07K14/195 , C07K14/31 , C07K16/14 , C12N1/21 , C12N15/00 , C12N15/31 , C12P21/02 , C12P21/08 , C12R1/445 , G01N33/53 , G01N33/566 , C07H21/00 , C12N15/63
摘要： The invention provides ftsY polypeptides and polynucleotides encoding ftsY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ftsY polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了编码ftsY多肽的ftsY多肽和多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用ftsY多肽筛选抗菌化合物的方法。
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6.发明授权Phospho-N-acetylmuramoyl-pentapeptide transferase of Streptococcus pneumoniae 失效肺炎链球菌的磷酸-N-乙酰基胞壁酰胺 - 五肽转移酶
公开(公告)号：US6156537A
公开(公告)日：2000-12-05
申请号：US61156
申请日：1998-04-16
申请人： Joanna Lynn Fueyo , Deborah Dee Jaworski , Anna Lisa Kosmatka , Michael Arthur Lonetto , Christopher Michael Traini , Min Wang
发明人： Joanna Lynn Fueyo , Deborah Dee Jaworski , Anna Lisa Kosmatka , Michael Arthur Lonetto , Christopher Michael Traini , Min Wang
IPC分类号： G01N33/15 , A61K31/70 , A61K31/7088 , A61K38/00 , A61K38/45 , A61K38/55 , A61K39/395 , A61K48/00 , C07K14/315 , C07K16/12 , C12N1/21 , C12N9/10 , C12N15/09 , C12N15/31 , C12N15/54 , C12P21/02 , C12Q1/68 , C12N15/52 , C12N15/62 , C12N15/63
摘要： The invention provides mraY polypeptides and polynucleotides encoding mraY polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mraY polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了mraY多肽和编码mraY多肽的多核苷酸以及通过重组技术产生这种多肽的方法。 还提供了利用mraY多肽筛选抗菌化合物的方法。
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公开(公告)号：US5883239A
公开(公告)日：1999-03-16
申请号：US896345
申请日：1997-07-18
申请人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
发明人： James Raymond Brown , Alison Frances Chalker , David John Payne , Lisa Kathleen Shilling , Christopher Michael Traini
IPC分类号： G01N33/53 , A61K31/70 , A61K38/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K16/40 , C12N9/00 , C12N9/10 , C12N15/00 , C12N15/09 , C12N15/54 , C12P21/02 , C12R1/46 , G01N33/566 , G01N33/569 , C07H21/02 , C07H21/04
CPC分类号： C12N9/1092
摘要： The invention provides aroA polypeptides and DNA (RNA) encoding aroA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing aroA polypeptides to screen for antibacterial compounds.
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公开(公告)号：US06448037B1
公开(公告)日：2002-09-10
申请号：US09026017
申请日：1998-02-20
IPC分类号： C07H2104
CPC分类号： C12N9/1288 , A61K38/00 , A61K39/00 , C12Y207/08005
摘要： The invention provides pgsA polypeptides and polynucleotides encoding pgsA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pgsA polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供pgsA多肽和编码pgsA多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用pgsA多肽筛选抗菌化合物的方法。
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公开(公告)号：US06303771B1
公开(公告)日：2001-10-16
申请号：US09080643
申请日：1998-05-18
申请人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
发明人： Sanjoy Biswas , James Raymond Brown , Christine Debouck , Deborah Dee Jaworski , Elizabeth Jane Lawlor , Jeffrey Mooney , Lisa Kathleen Shilling , Min Wang , Richard Lloyd Warren , Magdalena Zalacain , Yi Yi Zhong , John Peter Throup , Karen Anne Ingraham , Alison Frances Chalker , David John Holmes , Christopher Michael Traini
IPC分类号： C12N1531
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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公开(公告)号：US06274361B1
公开(公告)日：2001-08-14
申请号：US09080662
申请日：1998-05-18
申请人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
发明人： Sanjoy Biswas , Martin K. R. Burnham , Andrew P. Fosberry , John E Hodgson , Elizabeth J Lawlor , Tong Li , Damien McDevitt , Christopher Michael Traini , Martin Rosenberg , Judith Ward , Richard Lloyd Warren , Magdalena Zalacain
IPC分类号： C12N916
CPC分类号： C12N9/18
摘要： The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供第p多肽和编码第p多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用第p多肽筛选抗菌化合物的方法。
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