Abstract:
The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.
Abstract:
A hybrid prolapse repair material comprising a polypropylene and a graft body attached together. Attachments are provided for detachably attaching a repair material to a needle. A needle and a system for using the needle are contemplated to get repair material closer to the ischial spine. Graft to arm attachment concepts are taught to couple a mesh to a graft body. Additionally, a hysterectomy tool is provided to allow a surgeon to track vital organs.
Abstract:
Improved methods and apparatuses for treatment of pelvic organ prolapse are provided. A specialized sacral colpopexy mesh having a mesh cylinder attached to a first end of a main mesh is disclosed, and a method for use thereof in abdominal sacral colpopexy. A novel connector that is used to attach a mesh to the needle, including gripping features that improve the grip and allowing for easier connection and disconnection is disclosed, as well as a novel method and apparatus for connecting a mesh to a needle.
Abstract:
Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes inserting an intramural crossing device into the vascular lumen, positioning at least the distal tip of the crossing device in the vascular wall, advancing an orienting device over the crossing device such that an orienting element of the orienting device resides in the vascular wall, inserting a re-entry device, and re-entering the true vascular lumen.
Abstract:
Devices and methods for the treatment of chronic total occlusions are provided. One disclosed embodiment comprises a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method includes providing a first intravascular device having a distal portion with a concave side, inserting the first device into the vascular lumen, positioning the distal portion in the vascular wall, and orienting the concave side of the distal portion toward the vascular lumen.
Abstract:
The present invention is directed to compound of formula (A): wherein R1 is selected from (a) alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heteroaryl, or (b) CN and —C(NR10R11)═N—R12, R2 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl, R3-R12 are as described within the specification, and A is O, NR9 or S, or a prodrug, a pharmaceutically acceptable salt or a pharmaceutically active metabolite thereof, provided that R1 is not alkyl when R2 is pyridine, provided that at least one of R3-R8 is not H or F when A is O, R1 is (b) and R2 is a phenyl ring, a phenyl ring substituted at the para position with halo, —CN, —OCH3, —CF3 or —CO2CH3, a quinoline or an ethylene substituted with a phenyl ring or a 3,4-methylenedioxyphenyl moiety, provided that R4 is not methyl when R3 and R5-R8 are H, A is O, R1 is (b) and R2 is 4-chlorophenyl, and provided that R6 is not Cl when R3-R5 and R7-R8 are H, R1 is CN and R2 is phenyl. This invention is also directed to methods of using the same for treating HIV infections, or AIDS, or preventing replication.
Abstract:
According to various exemplary embodiments, an electronic text message is received from a source telephone number, the electronic text message including content describing a product item. A seller of the product item is identified, based on the source telephone number, and the product item is identified, based on the content included in the electronic text message. Thereafter, a draft version of an item listing is automatically generated, where the item listing lists the product item as being for sale by the seller on a marketplace website.
Abstract:
The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.
Abstract:
Methods and apparatus are provided for a seal assembly that includes a first plate, a second plate, and compliant material. The first and second plates each have a first side, a second side, and a channel extending therebetween. The channel includes a first cross-sectional area proximate the first side and a second cross-sectional area that is proximate the second side. The first cross-sectional area is greater than a second cross-sectional area. The compliant material is disposed between the first and second plates and is at least partially within the first plate channel and the second plate channel.
Abstract:
A fiber optic gyroscope (FOG) includes a sensing coil with a particular magnetic sensitivity magnitude and direction with respect to the geometric axis of the sensing coil. The FOG also includes a plurality of magnetic compensators. Each magnetic compensator is fabricated so as to have a particular magnetic sensitivity magnitude and direction, the magnitude being comparable to that of the sensing coil, with large tolerances relative to the magnitude and direction. The compensators are positioned relative to one another and to the sensing coil such that the combined magnetic sensitivities of the compensators cancel the magnetic sensitivity of the sensing coil.