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1.发明申请Method of Synthesizing and Purifying Dkk Proteins and Dkk Proteins Obtained Thereby 失效合成和纯化由此得到的Dkk蛋白质和Dkk蛋白质的方法公开(公告)号：US20080038775A1
公开(公告)日：2008-02-14
申请号：US10593089
申请日：2005-03-23
CPC分类号： C07K14/4703
摘要： The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.
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2.发明授权Method of synthesizing and purifying Dkk proteins and Dkk proteins obtained thereby 失效合成和纯化由此得到的Dkk蛋白质和Dkk蛋白质的方法公开(公告)号：US07867699B2
公开(公告)日：2011-01-11
申请号：US10593089
申请日：2005-03-23
CPC分类号： C07K14/4703
摘要： The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the synthetically produced essentially purified, glycosylated and biologically active Dkk protein, and the characteristics of the protein.
摘要翻译： 本发明涉及一种低成本合成大量基本上纯的，生物活性的糖基化Dkk蛋白质，包括哺乳动物和人类Dkk蛋白（例如人类Dkk1）的新方法。 本发明还涉及合成产生的基本纯化的糖基化和生物活性的Dkk蛋白质和蛋白质的特征。
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公开(公告)号：US20050070699A1
公开(公告)日：2005-03-31
申请号：US10477173
申请日：2002-05-13
申请人： Kristina Allen , Anthony Anisowicz , James Graham , Arturo Morales , Paul Yaworsky , Wei Liu
发明人： Kristina Allen , Anthony Anisowicz , James Graham , Arturo Morales , Paul Yaworsky , Wei Liu
IPC分类号： A01K67/027 , A61K35/00 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/00 , A61P19/00 , A61P19/10 , C07K14/47 , C07K14/51 , C07K16/18 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , C07H21/04 , C12N9/64
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
摘要： The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US07416849B2
公开(公告)日：2008-08-26
申请号：US10477173
申请日：2002-05-13
申请人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
发明人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
IPC分类号： G01N33/50 , C12N1/19 , C12N1/21 , C12N15/11 , C12N15/12 , C12N15/63 , C12N5/10 , C07K14/00 , C07K14/435
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
摘要： The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US20070128187A1
公开(公告)日：2007-06-07
申请号：US11655924
申请日：2007-01-22
申请人： Kristina Allen , Anthony Anisowicz , Veronique Damagnez , John Robinson , Paul Yaworsky , Bheem Bhat
发明人： Kristina Allen , Anthony Anisowicz , Veronique Damagnez , John Robinson , Paul Yaworsky , Bheem Bhat
IPC分类号： C12Q1/68 , G01N33/53 , A61K39/395 , A61K38/17 , C07K14/705 , C07K16/28 , C07H21/04 , C12P21/06
CPC分类号： C07K16/28 , C07K16/18 , C07K16/2863 , C07K16/30 , C07K2317/34 , G01N33/5041 , G01N33/6887 , G01N2333/4715 , G01N2500/02
摘要： The present invention provides reagents, compounds, compositions, and methods relating to novel interactions of the extracellular domain of LRP5, HBM (a variant of LRP5), and/or LRP6 with Dkk, including Dkk-1. The various nucleic acids, polypeptides, antibodies, assay methods, diagnostic methods, and methods of treatment of the present invention are related to and impact on Dkk, LRP5, LRP6, HBM, and Wnt signaling. Dkk, LRP5, LRP6, HBM, and Wnt are implicated in bone and lipid cellular signaling. Thus, the present invention provides reagents and methods for modulating lipid levels and/or bone mass and is useful in the treatment and diagnosis of abnormal lipid levels and bone mass disorders, such as osteoporosis.
摘要翻译： 本发明提供了与LRP5，HBM（LRP5的变体）和/或LRP6与Dkk（包括Dkk-1）的细胞外结构域的新的相互作用有关的试剂，化合物，组合物和方法。 本发明的各种核酸，多肽，抗体，测定方法，诊断方法和治疗方法与Dkk，LRP5，LRP6，HBM和Wnt信号传导有关并对其影响。 Dkk，LRP5，LRP6，HBM和Wnt涉及骨和脂质细胞信号传导。 因此，本发明提供用于调节脂质水平和/或骨量的试剂和方法，并且可用于治疗和诊断异常脂质水平和骨质量障碍，例如骨质疏松症。
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公开(公告)号：US20090136507A1
公开(公告)日：2009-05-28
申请号：US12219294
申请日：2008-07-18
申请人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
发明人： Kristina Allen , Anthony Anisowicz , James R. Graham , Arturo Morales , Paul J. Yaworsky , Wei Liu
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/50 , A01K2267/02 , A01K2267/03 , A01K2267/0362 , A61K38/00 , C07K14/51 , C07K16/18 , C12N2800/30 , C12N2800/60 , C12N2830/00 , C12N2830/008 , C12N2830/30 , C12N2840/105 , C12N2840/203 , G01N2333/51 , G01N2500/00
摘要： The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also relates to transgenic animals expressing the HBM-like polypeptides. The invention provides nucleic acids, including coding sequences, oligonucleotide primers and probes, proteins, cloning vectors, expression vectors, transformed hosts, methods of developing pharmaceutical compositions, methods of identifying molecules involved in bone development, and methods of diagnosing and treating diseases involved in bone development and lipid modulation. In preferred embodiments, the present invention is directed to methods for treating, diagnosing and preventing osteoporosis.
摘要翻译： 本发明涉及用于表达在动物细胞和转基因动物中衍生自HBM，LRP5或LRP6的HBM样多肽的方法和材料。 本发明还涉及表达HBM样多肽的转基因动物。 本发明提供核酸，包括编码序列，寡核苷酸引物和探针，蛋白质，克隆载体，表达载体，转化的宿主，开发药物组合物的方法，鉴定涉及骨发育的分子的方法，以及诊断和治疗涉及的疾病的方法 骨发育和脂质调节。 在优选的实施方案中，本发明涉及治疗，诊断和预防骨质疏松症的方法。
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公开(公告)号：US20110201782A1
公开(公告)日：2011-08-18
申请号：US13087480
申请日：2011-04-15
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C07K14/435
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/24
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译： 本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。
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8.发明申请NUCLEOTIDE AND AMINO ACID SEQUENCES RELATING TO RESPIRATORY DISEASES AND OBESITY 有权与呼吸道疾病和肥胖相关的核酸和氨基酸序列公开(公告)号：US20120100146A1
公开(公告)日：2012-04-26
申请号：US13341457
申请日：2011-12-30
申请人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
发明人： Tim Keith , Randall D. Little , Paul Van Eerdewegh , Josée Dupuis , Richard G. Del Mastro , Jason Simon , Kristina Allen , Sunil D. Pandit
IPC分类号： A61K39/395 , A61P11/06 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/24
摘要： This invention relates to genes identified from human chromosome 12q23-qter, which are associated with various diseases, including asthma. The invention also relates to the nucleotide sequences of these genes, isolated nucleic acids comprising these nucleotide sequences, and isolated polypeptides or peptides encoded thereby. The invention further relates to vectors and host cells comprising the disclosed nucleotide sequences, or fragments thereof, as well as antibodies that bind to the encoded polypeptides or peptides. Also related are ligands that modulate the activity of the disclosed genes or gene products. In addition, the invention relates to methods and compositions employing the disclosed nucleic acids, polypeptides or peptides, antibodies, and/or ligands for use in diagnostics and therapeutics for asthma and other diseases.
摘要翻译： 本发明涉及从人染色体12q23-qter鉴定的与各种疾病（包括哮喘）相关的基因。 本发明还涉及这些基因的核苷酸序列，包含这些核苷酸序列的分离的核酸，以及由此编码的分离的多肽或肽。 本发明还涉及包含所公开的核苷酸序列或其片段的载体和宿主细胞，以及结合编码的多肽或肽的抗体。 还涉及调节所公开的基因或基因产物的活性的配体。 此外，本发明涉及使用所公开的核酸，多肽或肽，抗体和/或配体用于诊断和治疗哮喘和其他疾病的方法和组合物。
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公开(公告)号：US08124734B2
公开(公告)日：2012-02-28
申请号：US13087480
申请日：2011-04-15
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josèe Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
IPC分类号： C07K1/00
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/24
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译： 本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。
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公开(公告)号：US07407804B1
公开(公告)日：2008-08-05
申请号：US10743704
申请日：2003-12-22
申请人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josée Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
发明人： Tim Keith , Randall Little , Paul Van Eerdewegh , Josée Dupuis , Richard Del Mastro , Jason Simon , Kristina Allen , Sunil Pandit
CPC分类号： C07K16/18 , C07K14/47 , C07K2317/24
摘要： This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or fragments thereof, as well as antibodies to the proteins encoded by these nucleic acids are also included herein.
摘要翻译： 本发明涉及包含人染色体12q23-qter的基因和由这些基因编码的蛋白质的分离的核酸。 包含这些基因或其片段的表达载体和宿主细胞以及由这些核酸编码的蛋白质的抗体也包括在本文中。
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