公开(公告)号：US10065045B2

公开(公告)日：2018-09-04

申请号：US15477475

申请日：2017-04-03

Applicant: Medtronic, Inc.

Inventor： Xusheng Zhang

IPC: A61N1/39 ,  A61B5/042 ,  A61B5/0456 ,  A61B5/04 ,  A61B5/0464 ,  A61B5/0452 ,  A61B5/00 ,  A61N1/362

Abstract: A method and medical device for detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, sensing a plurality of beats in response to the sensed cardiac signals, identifying each beat of the plurality of beats as one of a normal beat and a not normal beat, determining at least one of whether a number of beats identified as a normal beat is greater than a normal beat threshold, whether an RR interval associated with the beats identified as being a normal beat is less than a threshold interval, and whether RR intervals associated with the beats identified as being normal beats are within an RR interval range, and identifying the cardiac event as being one of shockable and not shockable in response to the determining.

公开(公告)号：US09808640B2

公开(公告)日：2017-11-07

申请号：US14250040

申请日：2014-04-10

Applicant: Medtronic, Inc.

Inventor： Xusheng Zhang

IPC: A61B5/04 ,  A61N1/39 ,  A61B5/00 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464

CPC classification number: A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7207

Abstract: A method and medical device for detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector sensing a first interval of the cardiac signal during a predetermined time period and a second sensing vector simultaneously sensing a second interval of the cardiac signal during the predetermined time period, identifying each of the first interval and the second interval as being one of shockable and not shockable in response to first processing of the first interval and the second interval and in response to second processing of one or both of the first interval and the second interval, the second processing being different from the first processing, and determining whether to deliver therapy for the cardiac event in response to identifying each of the first interval and the second interval as being one of shockable and not shockable in response to both the first processing and the second processing of the first interval and the second interval.

公开(公告)号：US09775559B2

公开(公告)日：2017-10-03

申请号：US14253408

申请日：2014-04-15

Applicant: Medtronic, Inc.

Inventor： Xusheng Zhang ,  Mark L Brown ,  Saul E Greenhut ,  Robert W Stadler

IPC: A61B5/00 ,  A61B5/04 ,  A61B5/0464 ,  A61N1/37 ,  A61N1/38 ,  A61N1/372 ,  A61N1/362 ,  A61N1/39

CPC classification number: A61B5/4836 ,  A61B5/04012 ,  A61B5/0464 ,  A61B5/7246 ,  A61N1/3621 ,  A61N1/3702 ,  A61N1/37264 ,  A61N1/37282 ,  A61N1/385 ,  A61N1/39

Abstract: A medical device and associated method for detecting and treating tachyarrhythmias acquires a cardiac signal using electrodes coupled to a sensing module. During an initial detection process, a shockable cardiac rhythm is detected by a processing module configured to compare the cardiac signal to a first set of detection criteria. By analyzing the cardiac signal, the processing module establishes at least one patient-specific detection threshold during the initial detection process. Upon establishing the at least one patient-specific detection threshold, the initial detection process is stopped, and a next detection process is started which includes comparing the cardiac signal to a second set of detection criteria including the at least one patient-specific detection threshold. In some embodiments, user programming of tachyarrhythmia detection parameters is not required.

公开(公告)号：US20160022166A1

公开(公告)日：2016-01-28

申请号：US14339789

申请日：2014-07-24

Applicant: MEDTRONIC, INC.

Inventor： Robert W. Stadler ,  Xusheng Zhang

IPC: A61B5/0452 ,  A61N1/362 ,  A61B5/0464

CPC classification number: A61B5/04525 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/686 ,  A61B5/7207 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/36535 ,  A61N1/36542 ,  A61N1/3702

Abstract: An implantable medical device system includes an implantable cardioverter defibrillator (ICD) for detecting and treating ventricular tachycardia (VT). The ICD includes a sensing module for sensing a cardiac signal from available cardiac signal sensing vectors. A control module generates morphology templates of the cardiac signals for multiple patient postures for each of the available sensing vectors and determines a set of posture-independent template features. An unknown cardiac rhythm is classified in response to comparing features of a cardiac signal received during the unknown rhythm to the set of posture-independent features.

Abstract translation: 可植入医疗装置系统包括用于检测和治疗室性心动过速（VT）的可植入式心律转复除颤器（ICD）。 ICD包括用于感测来自可用的心脏信号感测向量的心脏信号的感测模块。 控制模块针对每个可用感测向量生成用于多个患者姿势的心脏信号的形态学模板，并确定一组与姿势无关的模板特征。 响应于在未知节奏期间接收的心脏信号的特征与不依赖于姿势的特征的集合的特征来分类未知的心律。

公开(公告)号：US20160000350A1

公开(公告)日：2016-01-07

申请号：US14339156

申请日：2014-07-23

Applicant: Medtronic, Inc.

Inventor： Xusheng Zhang

IPC: A61B5/0464 ,  A61B5/04 ,  A61B5/0456 ,  A61N1/39

CPC classification number: A61N1/3987 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/686 ,  A61B5/7207 ,  A61B5/7221 ,  A61B5/7264 ,  A61B5/7282 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/37 ,  A61N1/3956

Abstract: A method and medical device for detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, sensing a plurality of beats in response to the sensed cardiac signals, identifying each beat of the plurality of beats as one of a normal beat and a not normal beat, determining at least one of whether a number of beats identified as a normal beat is greater than a normal beat threshold, whether an RR interval associated with the beats identified as being a normal beat is less than a threshold interval, and whether RR intervals associated with the beats identified as being normal beats are within an RR interval range, and identifying the cardiac event as being one of shockable and not shockable in response to the determining.

Abstract translation: 一种用于检测心脏事件的方法和医疗装置，其包括感测来自多个电极的心脏信号，响应于感测到的心脏信号感测多个心跳，将多个搏动中的每个搏动识别为正常搏动之一，以及 不是正常的拍子，确定被识别为正常拍子的数量是否大于正常拍子阈值中的至少一个，与被识别为正常拍子的节拍相关联的RR间隔是否小于阈值间隔，以及是否 与被识别为正常搏动的节拍相关联的RR间隔在RR间隔范围内，并且响应于确定将心脏事件识别为可震荡且不可震荡的。

公开(公告)号：US20150306408A1

公开(公告)日：2015-10-29

申请号：US14487248

申请日：2014-09-16

Applicant: Medtronic, Inc.

Inventor： Saul E. Greenhut ,  Robert W. Stadler ,  Xusheng Zhang

IPC: A61N1/39

CPC classification number: A61N1/3925 ,  A61B5/0456 ,  A61B5/0464 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7264 ,  A61N1/3706 ,  A61N1/3962 ,  A61N1/3987

Abstract: A method and medical device for adjusting a blanking period that includes sensing cardiac signals from a plurality of electrodes, the plurality of electrodes forming a plurality of sensing vectors, determining whether to adjust a blanking period during a first operating state, advancing from the first operating state to a second operating state in response to the sensed cardiac signals, determining, while in the second operating state, whether the blanking period was adjusted while in the first operating state, and adjusting the blanking period while in the second operating state in response to the blanking period being adjusted while in the first operating state.

Abstract translation: 一种用于调整消隐期的方法和医疗装置，包括感测来自多个电极的心脏信号，所述多个电极形成多个感测向量，确定是否在第一操作状态期间调整消隐期间，从第一操作 响应于所感测到的心脏信号状态到第二操作状态，在第二操作状态期间确定在第一操作状态期间是否调整消隐期间，并且响应于第二操作状态来调整处于第二操作状态的消隐期间 在第一操作状态下调整消隐期。

公开(公告)号：US20150290468A1

公开(公告)日：2015-10-15

申请号：US14250040

申请日：2014-04-10

Applicant: Medtronic, Inc.

Inventor： Xusheng Zhang

IPC: A61N1/39

CPC classification number: A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/04525 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/7207

Abstract: A method and medical device for detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector sensing a first interval of the cardiac signal during a predetermined time period and a second sensing vector simultaneously sensing a second interval of the cardiac signal during the predetermined time period, identifying each of the first interval and the second interval as being one of shockable and not shockable in response to first processing of the first interval and the second interval and in response to second processing of one or both of the first interval and the second interval, the second processing being different from the first processing, and determining whether to deliver therapy for the cardiac event in response to identifying each of the first interval and the second interval as being one of shockable and not shockable in response to both the first processing and the second processing of the first interval and the second interval.

Abstract translation: 一种用于检测心脏事件的方法和医疗装置，其包括感测来自多个电极的心脏信号，所述多个电极形成在预定时间段内感测心脏信号的第一间隔的第一感测向量，以及第二感测向量，同时感测心脏信号的第二间隔 在预定时间段期间，响应于第一间隔和第二间隔的第一处理以及响应于第一间隔和第二间隔中的一个或两者的第二处理，将第一间隔和第二间隔中的每一个识别为可震荡且不可震荡的一个 所述第一间隔和所述第二间隔，所述第二处理与所述第一处理不同，并且响应于将所述第一间隔和所述第二间隔中的每一个识别为可震荡且不可震荡的一个来确定是否对所述心脏事件进行治疗 对第一间隔和第二间隔的第一处理和第二处理的响应 e秒间隔。

公开(公告)号：US20150272460A1

公开(公告)日：2015-10-01

申请号：US14735906

申请日：2015-06-10

Applicant: Medtronic, Inc.

Inventor： Robert W. Stadler ,  Raja N. Ghanem ,  Xusheng Zhang

IPC: A61B5/046 ,  A61N1/39 ,  A61B5/0464 ,  A61B5/00 ,  A61B5/04 ,  A61B5/0468

CPC classification number: A61N1/3987 ,  A61B5/04011 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0468 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/7203 ,  A61B5/7221 ,  A61B5/7239 ,  A61N1/05 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/3956 ,  Y10S128/901 ,  Y10S128/902

Abstract: A method and system for use with an implantable medical device for subcutaneous implant within a patient to determine a likelihood of the patient experiencing a cardiac event that includes sensing a cardiac signal along a plurality of different sensing vectors, determining state information of each vector of the plurality of sensing vectors, determining a cross correlation of the determined state information of each vector of the plurality of sensing vectors, comparing the cross correlation of the determined state information of each vector of the plurality of sensing vectors to a threshold, and detecting the cardiac event in response to the comparing.

Abstract translation: 一种与可植入医疗装置一起使用以在患者体内皮下植入以确定患者经历心脏事件的可能性的方法和系统，其包括沿着多个不同感测向量感测心脏信号，确定每个矢量的状态信息 多个感测向量，确定所述多个感测向量中的每个向量的所确定的状态信息的互相关，将所述多个感测向量中的每个向量的所确定的状态信息的互相关与阈值进行比较，以及检测心脏 事件响应比较。

公开(公告)号：US20150202436A1

公开(公告)日：2015-07-23

申请号：US14158516

申请日：2014-01-17

Applicant: Medtronic, Inc.

Inventor： Todd M. Zielinski ,  Yong Kyun Cho ,  Douglas Hettrick ,  Xusheng Zhang

IPC: A61N1/368 ,  A61N1/365

CPC classification number: A61N1/368 ,  A61N1/36521 ,  A61N1/3682

Abstract: Methods and/or devices used in delivering cardiac resynchronization therapy based on a plurality of device parameters (e.g., A-V delay, V-V delay, etc.) are optimized by setting a device parameter based on selection data. The selection data may be acquired by acquiring temporal fiducial points (e.g., heart sounds) associated with at least a part of a systolic portion of at least one cardiac cycle and/or temporal fiducial points associated with at least a part of a diastolic portion of the at least one cardiac cycle for each of a plurality of electrode vector configurations, and extracting measurements from the intracardiac impedance signal acquired for each of a plurality of electrode vector configurations based on the temporal fiducial points. The acquired selection data may be scored and used to optimize the device parameter.

Abstract translation: 通过基于选择数据设置设备参数来优化基于多个设备参数（例如，A-V延迟，V-V延迟等）递送心脏再同步治疗的方法和/或设备。 选择数据可以通过获取与至少一个心动周期的收缩期部分的至少一部分相关联的时间基准点（例如，心音）和/或与至少一个心动周期的舒张部分的至少一部分相关联的时间基准点来获取 所述至少一个心脏周期用于多个电极向量配置中的每一个，并且基于所述时间基准点从针对多个电极向量配置中的每一个获取的心脏内阻抗信号提取测量值。 可以对所获取的选择数据进行评分并用于优化设备参数。

公开(公告)号：US20140276159A1

公开(公告)日：2014-09-18

申请号：US13826248

申请日：2013-03-14

Applicant: MEDTRONIC, INC.

Inventor： Xusheng Zhang

IPC: A61B5/0452

CPC classification number: A61B5/04525 ,  A61B5/0468 ,  A61B5/686 ,  A61N1/3621 ,  A61N1/3622

Abstract: A medical device and associated method for classifying an unknown cardiac signal sensing a cardiac signal over a plurality of cardiac cycles using a plurality of electrodes coupled to a sensing module, determining a template of a known cardiac signal in response to the cardiac signal sensed over the plurality of cardiac cycles, sensing an unknown cardiac signal over an unknown cardiac cycle, determining a fourth order difference signal corresponding to the template and a fourth order difference signal of the unknown cardiac signal, determining a first morphology match metric between the template fourth order difference signal and the fourth order difference signal of the unknown cardiac signal, and classifying the unknown cardiac signal in responsed to the determined first morphology match score.

Abstract translation: 一种用于使用耦合到感测模块的多个电极在多个心动周期上感测心脏信号的未知心脏信号进行分类的医疗装置和相关方法，响应于在所述心脏信号上感测到的心脏信号，确定已知心脏信号的模板 多个心脏周期，感测未知心脏周期上的未知心脏信号，确定对应于模板的第四阶差分信号和未知心脏信号的第四阶差分信号，确定模板四阶差分之间的第一形态匹配度量 信号和未知心脏信号的四阶差分信号，并且响应于确定的第一形态匹配分数对未知心脏信号进行分类。