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17 条记录 (耗时 0.078 秒)

    Substituted Diazabicycloalkane Derivates
    16.
    发明申请
    Substituted Diazabicycloalkane Derivates 有权
    取代的二氮杂双环烷烃衍生物

    公开(公告)号：US20080275048A1

    公开(公告)日：2008-11-06

    申请号：US12132009

    申请日：2008-06-03

    申请人： Jennifer M. Frost ,  Jianguo Ji ,  Tao Li ,  Diana L. Nersesian ,  Karin R. Tietje

    发明人： Jennifer M. Frost ,  Jianguo Ji ,  Tao Li ,  Diana L. Nersesian ,  Karin R. Tietje

    IPC分类号： A61K31/53 ,  A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/4178 ,  C07D403/14

    CPC分类号： A61K31/501 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/506 ,  A61K31/53

    摘要： Compounds of formula (I) Z-Ar1—Ar2   (I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

    摘要翻译： 式（I）化合物<？in-line-formula description =“In-line Formulas”end =“lead”？> Z-Ar 1 -Ar 2 I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中Z是二氮杂双环胺，Ar 1是5或6元芳环 和Ar 2 2选自未取代或取代的5或6元杂芳基环; 未取代或取代的双环杂芳基环; 3,4-（亚甲二氧基）苯基; 咔唑基; 四氢咔唑基; 萘基; 和苯基; 其中苯基在间位或对位被0,1,2或3个取代基取代。 该化合物可用于治疗由α7nAChR配体预防或改善的病症或病症。 还公开了包含式（I）化合物和使用这些化合物和组合物的方法的药物组合物。

    Adenosine-5'-carboxamides and method of use
    17.
    发明授权
    Adenosine-5'-carboxamides and method of use 失效
    腺苷-5 {40-甲酰胺和使用方法

    公开(公告)号：US4167565A

    公开(公告)日：1979-09-11

    申请号：US739684

    申请日：1976-11-08

    申请人： Herman H. Stein ,  Raj N. Prasad ,  Karin R. Tietje ,  Anthony K. L. Fung

    发明人： Herman H. Stein ,  Raj N. Prasad ,  Karin R. Tietje ,  Anthony K. L. Fung

    IPC分类号： C07H19/16 ,  A61K31/52

    CPC分类号： C07H19/16

    摘要： A method of controlling undesired animals including rodents, coyotes and birds which comprises making available to said animals an edible composition containing, as the active ingredient, a lethal dose of a compound represented by formula ##STR1## wherein R is H, loweralkyl or acetyl; R.sub.1 is H or acetyl; R.sub.2 is H, Cl or NH.sub.2 ; R.sub.3 is H, loweralkyl, alkoxy, cycloalkyl or hydroxyalkyl; R.sub.4 and R.sub.5 are each H, acetyl or propionyl, or when taken together form a p-chlorobenzylidene, a carbonate or an ethoxymethylene moiety; in a suitable carrier.

    摘要翻译： 一种控制不需要的动物（包括啮齿动物，土拨鼠和鸟类）的方法，其包括向所述动物提供可食用组合物，所述可食用组合物含有作为活性成分的致死剂量的由式（1）+ tr 2）其中R为H，低级烷基或乙酰基; R1是H或乙酰基; R2是H，Cl或NH2; R3是H，低级烷基，烷氧基，环烷基或羟烷基; R 4和R 5各自为H，乙酰基或丙酰基，或者当一起形成对氯亚苄基，碳酸酯或乙氧基亚甲基部分时; 在合适的载体中。