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公开(公告)号：US07611692B2
公开(公告)日：2009-11-03
申请号：US10828925
申请日：2004-04-20
申请人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf E. Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf E. Swenson , Michael Tweedle
IPC分类号： A61K49/00
CPC分类号： C07K7/086 , A61K51/088
摘要： New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
摘要翻译： 用于具有式MNOPG的诊断成像或治疗的新的和改进的化合物，其中M是光学标记或金属螯合剂（以与金属放射性核素复合的形式），NOP是接头，G是GRP受体 靶向肽。 还提供了使用本发明的化合物对患者成像和/或向患者提供放射治疗或光疗的方法。 还提供了用于从该化合物制备诊断显像剂的方法和试剂盒。 还提供了用于制备放射治疗剂的方法和试剂盒。
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公开(公告)号：US20110052491A1
公开(公告)日：2011-03-03
申请号：US12551394
申请日：2009-08-31
申请人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf E. Swenson , Michael Tweedle
发明人： Enrico Cappelletti , Luciano Lattuada , Karen E. Linder , Edmund Marinelli , Palaniappa Nanjappan , Natarajan Raju , Kondareddiar Ramalingam , Rolf E. Swenson , Michael Tweedle
CPC分类号： C07K7/086 , A61K51/088
摘要： New and improved compounds for use in diagnostic imaging or therapy having the formula M—N—O—P—G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N—O—P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.
摘要翻译： 用于具有式M-N-O-P-G的诊断成像或治疗的新的和改进的化合物，其中M是光学标记或金属螯合剂（以与金属放射性核素复合的形式），N-O -P是接头，G是靶向GRP受体的肽。 还提供了使用本发明的化合物对患者成像和/或向患者提供放射治疗或光疗的方法。 还提供了用于从该化合物制备诊断显像剂的方法和试剂盒。 还提供了用于制备放射治疗剂的方法和试剂盒。
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13.发明申请KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号：US20110097275A1
公开(公告)日：2011-04-28
申请号：US12898119
申请日：2010-10-05
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan
CPC分类号： A61K49/221 , A61K38/00 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽，特别是造影剂的二聚体和多聚体构建体。 还提供了使用本发明的造影剂监测和评估与血管生成或内皮细胞过度增殖相关的疾病（例如癌症）的治疗方案的治疗有效性的方法。
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14.发明授权KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 有权KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号：US08642010B2
公开(公告)日：2014-02-04
申请号：US12480578
申请日：2009-06-08
申请人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Feng Yan , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号：US07854919B2
公开(公告)日：2010-12-21
申请号：US11624894
申请日：2007-01-19
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield , Ajay Shrivastava
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield , Ajay Shrivastava
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。
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公开(公告)号：US08632753B2
公开(公告)日：2014-01-21
申请号：US12972965
申请日：2010-12-20
申请人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：US20110286929A1
公开(公告)日：2011-11-24
申请号：US12972965
申请日：2010-12-20
申请人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
CPC分类号： A61K47/48246 , A61K38/16 , A61K47/42 , A61K47/60 , A61K47/64 , A61K49/221 , A61K49/223 , C07K7/08 , C07K7/64 , Y02A50/411
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：US20110070165A1
公开(公告)日：2011-03-24
申请号：US12888736
申请日：2010-09-23
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna K. Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Feng Yan , Aaron K. Sato , Sharon Michele Walker , Daniel T. Dransfield
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
摘要翻译： 本发明提供用于治疗和诊断应用的组合物和方法。
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19.发明申请KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 有权KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用公开(公告)号：US20100003195A1
公开(公告)日：2010-01-07
申请号：US12480578
申请日：2009-06-08
申请人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
发明人： Aaron K. Sato , Daniel J. Sexton , Daniel T. Dransfield , Robert C. Ladner , Christophe Arbogast , Philippe Bussat , Hong Fan , Sudha Khurana , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian D. Nunn , Radhakrishna Pillai , Sibylle Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski
IPC分类号： A61K49/22
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
摘要翻译： 本发明提供了包含用于KDR或VEGF / KDR复合物的至少一个结合部分的多肽，肽二聚体和多聚体复合物，其具有各种用途，无论何处治疗，检测，分离或定位血管发生都是有利的。 特别公开的是能够以高亲和力（例如具有KD <1μM）结合KDR或VEGF / KDR复合物的合成，分离的多肽，以及包含这些多肽的二聚体和多聚体构建体。
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公开(公告)号：US07211240B2
公开(公告)日：2007-05-01
申请号：US10379287
申请日：2003-03-03
申请人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sybille Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
发明人： Christophe Arbogast , Philippe Bussat , Hong Fan , Karen E. Linder , Edmund R. Marinelli , Palaniappa Nanjappan , Adrian Nunn , Radhakrishna Pillai , Sybille Pochon , Kondareddiar Ramalingam , Ajay Shrivastava , Bo Song , Rolf E. Swenson , Mathew A. Von Wronski , Aaron Sato , Sharon Michele Walker , Daniel T. Dransfield
IPC分类号： A61K49/00
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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