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公开(公告)号：US20130155402A1
公开(公告)日：2013-06-20
申请号：US13819397
申请日：2011-08-31
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译： 具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光镜读取器。 光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。 通常，目标在光谱询问期间相对于光学头移动。 因此，光谱阅读器是一种在线阅读器，非常适合随着目标沿生产或分析线路的移动而实时提供基于频谱的生产或分析决策。 还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。
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公开(公告)号：US20130009119A1
公开(公告)日：2013-01-10
申请号：US13635559
申请日：2011-03-22
CPC分类号： G01N21/658 , B82Y20/00 , B82Y30/00 , G01N2201/06113 , H01S3/30 , Y10S977/81 , Y10S977/834
摘要： Wavelength selective particles such as SERS nanotags modified for wavelength selectivity. As used herein, a wavelength selective particle is one which cannot be effectively excited or interrogated at one or more wavelengths where a reporter molecule associated with the particle would normally produce a spectrum. Also disclosed are methods of manufacturing wavelength selective particles and methods of tagging materials or objects with wavelength selective particles.
摘要翻译： 波长选择性颗粒，如SERS纳米复合材料修饰波长选择性。 如本文所用，波长选择性颗粒是在与颗粒相关的报告分子通常产生光谱的一个或多个波长处不能有效激发或询问的粒子。 还公开了制造波长选择性颗粒的方法和用波长选择性颗粒标记材料或物体的方法。
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公开(公告)号：US20100233816A1
公开(公告)日：2010-09-16
申请号：US12723462
申请日：2010-03-12
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , Y10T436/13
摘要： Methods and compositions of matter are disclosed for creating tags such as SERS nanotags which are dispersible in an organic solvent. The tags are inherently hydrophilic and may be made dispersible in an organic solvent by associating the tag with an amphiphilic polymer. Alternatively, a tag may be associated with a surfactant. In another embodiment a tag having an encapsulant of a silicon containing material may be made dispersible in an organic solvent by modifying the encapsulant surface with a hydrophobic silane. In addition, a tag having an encapsulant of a silicon containing material may be modified by the esterification of the encapsulant with an alcohol.
摘要翻译： 公开了用于产生可分散在有机溶剂中的标签如SERS纳米颗粒的方法和组合物。 标签本身是亲水性的，并且可以通过将标签与两亲性聚合物缔合而使其分散在有机溶剂中。 或者，标签可以与表面活性剂相关联。 在另一个实施方案中，具有含硅材料的密封剂的标签可以通过用疏水性硅烷改性密封剂表面而制成分散在有机溶剂中。 此外，具有含硅材料的密封剂的标签可以通过密封剂与醇的酯化来改性。
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公开(公告)号：US09261403B2
公开(公告)日：2016-02-16
申请号：US13819397
申请日：2011-08-31
CPC分类号： G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/0272 , G01J3/0291 , G01J3/0294 , G01J3/2803 , G01J3/44 , G01N21/85 , G01N21/8901 , G07D7/1205
摘要： An inline spectroscopic reader having a light source, one or more optics heads, a spectrometer and a data processing system in digital communication with the spectrometer detector. The optics heads include transmission optics providing for the illumination of a target with light from the light source and detection optics providing for the collection of light from the target. Typically, the target is moving with respect to the optics head during spectroscopic interrogation. The spectroscopic reader is thus an inline reader well suited to provide spectrum based production or analytical decision making in real time as the target moves along a production or analysis line. Also disclosed are methods including the steps of illuminating a target with light from a light source; collecting light from the target; obtaining a digitized spectrum with a spectrometer; extracting information content from the digitized spectrum; and basing a contemporaneous process decision upon the information content.
摘要翻译： 具有光源，一个或多个光学头，光谱仪和与光谱仪检测器进行数字通信的数据处理系统的在线分光镜读取器。 光学头包括传输光学器件，用于提供来自光源的光的目标照明和用于从目标物体收集光的检测光学器件。 通常，目标在光谱询问期间相对于光学头移动。 因此，光谱阅读器是一种在线阅读器，非常适合随着目标沿生产或分析线路的移动而实时提供基于频谱的生产或分析决策。 还公开了包括用来自光源的光照射目标的步骤的方法; 从目标收集光; 用光谱仪获得数字化光谱; 从数字化频谱中提取信息内容; 并对信息内容进行同时代的过程决策。
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15.发明授权Particles comprising hollow surface-enhanced spectroscopy (SES)-active core for long wavelength SERS 有权颗粒包括用于长波长SERS的中空表面增强光谱（SES）活性核心公开(公告)号：US09239327B2
公开(公告)日：2016-01-19
申请号：US13319648
申请日：2010-05-18
申请人： Michael J. Natan , Richard Griffith Freeman , Marcelo Eduardo Piotti , William E. Doering , Felicia Tam
发明人： Michael J. Natan , Richard Griffith Freeman , Marcelo Eduardo Piotti , William E. Doering , Felicia Tam
IPC分类号： G01N37/00 , G01N33/532 , G01N21/65 , G01N33/28
CPC分类号： G01N33/532 , G01N21/658 , G01N33/28
摘要： Embodiments include a particle comprising a surface enhanced spectroscopy (SES)-active core and a SES-active reporter molecule associated with the SES-active core wherein said particle has a measurable SES spectrum when excited by incident light having a wavelength of at least 1400 nm. Alternative embodiments include methods of manufacturing said particle and methods of tagging a material with said particle. The particle may include an SES-active core which supports plasmon resonance at a wavelength of at least 1400 nm. The particle may comprise an anisotropic core. The particle may include an SES-active reporter molecule which is resonant at one or more wavelengths greater than or equal to 1400 nm.
摘要翻译： 实施方案包括包含表面增强光谱（SES）活性核心和与SES活性核心相关的SES活性报道分子的颗粒，其中当波长为至少1400nm的入射光激发时，所述颗粒具有可测量的SES光谱 。 替代实施例包括制造所述颗粒的方法和用所述颗粒标记材料的方法。 颗粒可以包括在至少1400nm的波长下支持等离子体共振的SES活性核心。 颗粒可以包括各向异性核。 颗粒可以包括在大于或等于1400nm的一个或多个波长处共振的SES活性报道分子。
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16.发明授权Methods of use for surface enhanced spectroscopy-active composite nanoparticles 有权表面增强光谱活性复合纳米粒子的使用方法公开(公告)号：US08918161B2
公开(公告)日：2014-12-23
申请号：US12245538
申请日：2008-10-03
CPC分类号： B22F9/14 , B22F1/0025 , B22F2001/0037 , B22F2998/00 , B82Y30/00 , C25D1/006 , C25D1/04 , G01N21/658 , G01N33/54346 , G01N2201/06113 , G01N2201/068 , Y10T436/13 , B22F1/0018 , B22F1/025 , B22F1/02
摘要： Various methods of use for surface enhanced spectroscopy-active composite nanoparticles (SACN's) are provided. SACN's are submicron-sized particles or labels can be covalently or non-covalently affixed to entities of interest for the purpose of quantification, location, identification, tracking, and diagnosis. The various methods include administering a SACN nanoparticle imaging agent to a patient, scanning the patient using a system that can perform spectral imaging; and generating a spectrum or image of an internal region of the patient. A method, for diagnosing an abnormal pathology as well as a method for labeling an animal with a SACN are also provided.
摘要翻译： 提供了表面增强光谱 - 活性复合纳米粒子（SACN）的各种使用方法。 SACN是亚微米尺寸的颗粒，或者标签可以共价或非共价地附着于感兴趣的实体，用于定量，定位，鉴定，跟踪和诊断。 各种方法包括向患者施用SACN纳米颗粒显像剂，使用可进行光谱成像的系统扫描患者; 以及产生患者的内部区域的光谱或图像。 还提供了用于诊断异常病理学的方法以及用SACN标记动物的方法。
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公开(公告)号：US08574916B2
公开(公告)日：2013-11-05
申请号：US13124808
申请日：2009-11-17
CPC分类号： G01N21/658 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
摘要翻译： 一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS活性颗粒与含有三聚氰胺的溶液混合。 该方法还包括检测三聚氰胺的表面增强拉曼光谱。 上述方法可以任选地包括聚集SERS活性颗粒。 在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。 检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。 该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。 该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准品与含有三聚氰胺和SERS-活性颗粒的溶液混合。 测定装置和系统也被公开。
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公开(公告)号：US20110207231A1
公开(公告)日：2011-08-25
申请号：US13124808
申请日：2009-11-17
CPC分类号： G01N21/658 , Y10T436/14 , Y10T436/145555 , Y10T436/147777
摘要： A method of detecting melamine which includes providing a quantity of SERS-active particles and mixing the SERS-active particles with a solution containing melamine. The method further includes detecting a surface enhanced Raman spectrum of the melamine. The foregoing method may optionally include aggregating the SERS-active particles. Aggregation may occur before or after the SERS-active particles are mixed with a solution containing melamine. The method of detecting melamine may optionally include concentration of the SERS-active particles. The method may further include mixing a chaotropic agent having a higher affinity for a selected binding site than melamine into the solution containing melamine. The method may further include mixing a quantity of a SERS-active standard having a known SERS spectrum with the solution containing melamine and SERS-active particles. Assay apparatus and systems are also disclosed.
摘要翻译： 一种检测三聚氰胺的方法，其包括提供一定量的SERS-活性颗粒并将SERS活性颗粒与含有三聚氰胺的溶液混合。 该方法还包括检测三聚氰胺的表面增强拉曼光谱。 上述方法可以任选地包括聚集SERS活性颗粒。 在SERS-活性颗粒与含有三聚氰胺的溶液混合之前或之后，聚集可能发生。 检测三聚氰胺的方法可以任选地包括SERS活性颗粒的浓度。 该方法还可以包括将具有比三聚氰胺选择的结合位点更高亲和力的离液剂混合到含有三聚氰胺的溶液中。 该方法还可以包括将一定数量的具有已知SERS光谱的SERS-活性标准品与含有三聚氰胺和SERS-活性颗粒的溶液混合。 测定装置和系统也被公开。
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公开(公告)号：US20110124117A1
公开(公告)日：2011-05-26
申请号：US12665379
申请日：2008-06-30
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01N33/54326 , G01N33/54346 , G01N33/54393 , G01N33/553
摘要： Methods and systems for the use of surface-enhanced Raman scattering nanotags (SERS nanotags) in various assay platforms which feature accelerated reaction kinetics. One embodiment includes a method detecting a substance of interest by associating a SERS nanotag with the substance of interest while accelerating the reaction kinetics of the association steps. This method also includes detecting a Raman spectrum of a reporter molecule associated with the SERS nanotag. The reaction kinetics of the assay may be accelerated by applying microwave radiation to the sample, heating the sample, agitating the sample, mixing the sample, vibrating the sample or other methods.
摘要翻译： 在具有加速反应动力学的各种测定平台中使用表面增强拉曼散射纳米颗粒（SERS纳米标签）的方法和系统。 一个实施方案包括通过在加速缔合步骤的反应动力学的同时使SERS纳米标记与目标物质相关联来检测感兴趣的物质的方法。 该方法还包括检测与SERS纳米颗粒相关的报告分子的拉曼光谱。 可以通过对样品施加微波辐射，加热样品，搅拌样品，混合样品，振动样品或其他方法来加速测定的反应动力学。
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