利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

26 条记录 (耗时 0.037 秒)

    TAN-1511, its derivatives, production and use thereof
    14.
    发明授权
    TAN-1511, its derivatives, production and use thereof 失效
    TAN-1511，其衍生物，生产和使用

    公开(公告)号：US5478809A

    公开(公告)日：1995-12-26

    申请号：US174365

    申请日：1993-12-28

    申请人： Seiichi Tanida ,  Tsuneaki Hida ,  Mitsuhiro Wakimasu

    发明人： Seiichi Tanida ,  Tsuneaki Hida ,  Mitsuhiro Wakimasu

    IPC分类号： A61K38/00 ,  C07K5/06 ,  C07K5/083 ,  C07K5/103 ,  C07K7/06 ,  C07K5/00 ,  C07K7/00 ,  C07K17/00

    CPC分类号： C07K7/06 ,  C07K5/0606 ,  C07K5/081 ,  C07K5/1013 ,  A61K38/00

    摘要： A compound of the formula: ##STR1## wherein each R.sup.1, R.sup.2 and R.sup.3 is an aliphatic acyl group, X is an amino acid sequence consisting of 1 to 5 amino acid residues which contain at least one acidic amino acid residue, n is an integer of 0 to 4, provided that when n is 0, X has glutamyl-glycyl at its N-terminal and when n is 1 or 2, the acidic amino acid residue is an acidic amino acid residue other than D-glutamyl, or a salt thereof has an activity of remarkably improving anhematopoiesis and is useful as an immuno-stimulating agent having a leukocyte-increasing activity.

    摘要翻译： 下式的化合物：其中每个R 1，R 2和R 3是脂族酰基，X是由1至5个氨基酸残基组成的氨基酸序列，其含有至少一个酸性氨基酸残基，n是整数 为0〜4，条件是当n为0时，X在其N-末端具有谷氨酰 - 甘氨酰，当n为1或2时，酸性氨基酸残基为除D-谷氨酰以外的酸性氨基酸残基或盐 其具有显着改善造血作用的活性，并且可用作具有白细胞增加活性的免疫刺激剂。

    Peptide derivatives, their production and use
    18.
    发明授权
    Peptide derivatives, their production and use 失效
    肽衍生物，其生产和使用

    公开(公告)号：US4748154A

    公开(公告)日：1988-05-31

    申请号：US939103

    申请日：1986-12-08

    申请人： Giichi Goto ,  Akinobu Nagaoka ,  Mitsuhiro Wakimasu

    发明人： Giichi Goto ,  Akinobu Nagaoka ,  Mitsuhiro Wakimasu

    IPC分类号： C07K14/575 ,  A61K38/00 ,  A61K38/11 ,  A61P25/00 ,  C07K1/02 ,  C07K1/113 ,  C07K7/06 ,  C07K7/16 ,  A61K37/02

    CPC分类号： C07K7/16 ,  A61K38/00 ,  Y02P20/55 ,  Y10S930/26

    摘要： A peptide derivative of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1-18 alkyl group or a substituted or unsubstituted phenyl C.sub.1-3 alkyl group;A is an amino or N--C.sub.1-6 alkylamino acid residue;B is a hydroxyl group, a substituted or unsubstituted amino group, or an amino acid or an amide thereof,or a physiologically acceptable salt thereof, can be advantageously used for the treatment and/or prevention of a disease including, among others, senile dementia (Alzheimer's dementia), cerebrovascular dementia, Alzheimer's disease, Pick's disease, Huntington's chorea, Creutzfeldt-Jakob disease, Parkinson's disease, and dementia due to spinocerebellar degeneration.

    摘要翻译： 通式为“IMAGE”的肽衍生物，其中R 1为氢原子，C 1-18烷基或取代或未取代的苯基C 1-3烷基; A是氨基或N-C 1-6烷基氨基酸残基; B是羟基，取代或未取代的氨基或氨基酸或其酰胺或其生理学上可接受的盐可有利地用于治疗和/或预防疾病，包括老年性痴呆 （阿尔茨海默氏痴呆症），脑血管性痴呆，阿尔茨海默病，皮克病，亨廷顿舞蹈病，克雅氏病，帕金森氏病和由脊髓小脑变性引起的痴呆。

    Novel polypeptides
    19.
    发明授权
    Novel polypeptides 失效
    新型多肽

    公开(公告)号：US4073890A

    公开(公告)日：1978-02-14

    申请号：US726052

    申请日：1976-09-23

    申请人： Masahiko Fujino ,  Mitsuhiro Wakimasu ,  Shigehisa Taketomi ,  Eiichiro Ishikawa

    发明人： Masahiko Fujino ,  Mitsuhiro Wakimasu ,  Shigehisa Taketomi ,  Eiichiro Ishikawa

    IPC分类号： A61K38/00 ,  C07K5/087 ,  C07K5/11 ,  C07K14/62 ,  A61K37/00 ,  C07C103/52

    CPC分类号： C07K5/1019 ,  C07K14/62 ,  C07K5/0812 ,  A61K38/00

    摘要： Novel polypeptides of the formulaR.sub.1 --Arg--R.sub.2 --Phe--Phe--R.sub.3wherein R.sub.1 is hydrogen, or a basic or neutral amino acid residue, R.sub.2 is a neutral amino acid residue and R.sub.3 is NH.sub.2, Tyr--NH.sub.2, a residue of tyrosyl peptides consisting of 1 to 5 amino acid residues or amides of the tyrosyl peptides, provided that when R.sub.1 is hydrogen, R.sub.2 is Pro, are effectively used for treatment of insufficiency of carbohydrate metabolism and of lipid metabolism, especially for the treatment of diabetes by not only parenteral administration but also oral administration.

    摘要翻译： 式R1-Arg-R2-Phe-Phe-R3的新型多肽，其中R1是氢，或碱性或中性氨基酸残基，R2是中性氨基酸残基，R3是NH2，Tyr-NH2，酪氨酰基的残基 由酪氨酰肽的1至5个氨基酸残基或酰胺组成的肽，条件是当R1为氢时，R2为Pro，可有效用于治疗碳水化合物代谢和脂质代谢不足，特别是用于治疗糖尿病 只有肠胃外给药，而且口服。