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公开(公告)号：US5021439A
公开(公告)日：1991-06-04
申请号：US408389
申请日：1989-09-18
Applicant: Setsuo Harada , Akinobu Nagaoka , Katsumi Itoh , Shinji Terao
Inventor： Setsuo Harada , Akinobu Nagaoka , Katsumi Itoh , Shinji Terao
IPC: A61K38/00 , C07D207/26 , C07D207/277 , C07D261/12 , C07D405/06 , C07D413/06 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/078
CPC classification number: C07D207/277 , C07D261/12 , C07D405/06 , C07D413/06 , C07K5/0215 , C07K5/06026 , C07K5/06078 , C07K5/06086 , C07K5/06139 , A61K38/00 , Y02P20/55
Abstract: A compound having the formula (I) or (II) ##STR1## wherein R.sup.1 is a hydrogen atom or an organic residue bonded via a carbon atom, R.sup.2 is a hydrogen atom or a N-protecting group, --COR.sup.3 is an optionally esterified or amidated carboxyl group, R.sup.4 and R.sup.5 are the same or different and respectively a hydrogen atom or an acyl group or a chain or alicyclic hydrocarbon group optionally having an aryl substituent, R.sup.6 is NOH or O, n is an integer of 0 to 3, or R.sup.4 and R.sup.5 together with the adjacent nitrogen atom may form a ring or an optionally substituted benzylidene amino group, which is useful therapeutics of brain dysfunction.
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公开(公告)号：US4932368A
公开(公告)日：1990-06-12
申请号：US303658
申请日：1989-01-30
Applicant: Ryoji Abe , Setsuo Harada , Kouji Asanomi , Kouichi Hatamura , Toshikazu Kurokawa , Tsuyoshi Goto , Shinji Seike
Inventor： Ryoji Abe , Setsuo Harada , Kouji Asanomi , Kouichi Hatamura , Toshikazu Kurokawa , Tsuyoshi Goto , Shinji Seike
IPC: F02B75/22 , F02F1/24 , F02F1/42 , F02M35/116
CPC classification number: F02F1/4235 , F02M35/10157 , F02M35/116 , F02B2275/18 , F02B75/22 , F02F2001/245 , F02M35/10045 , F02M35/10216 , Y02T10/144
Abstract: In a V-type internal combustion engine having a pair of upwardly diverging cylinder banks and an auxiliary unit disposed at an upper portion in a space defined between the cylinder banks, a suction arrangement includes intake ports provided at an inner side of the respective cylinder banks, inclined inwardly by a predetermined angle with respect to respective clyinder axes, and extending upwardly in a generally vertical direction so as not to interfere with the auxiliary unit, and cylinder communicating portions connected to upper portions of the intake ports in communication with the respective cylinders to permit the introduction of the intake gas thereto.
Abstract translation: 在具有一对向上发散的气缸组的V型内燃机和设置在气缸组之间的空间中的上部的辅助单元中，抽吸装置包括设置在各气缸组的内侧的进气口 相对于各自的绞线轴线向内倾斜预定角度，并且在大致垂直的方向上向上延伸，以便不与辅助单元干涉，以及连接到与各个气缸连通的进气口的上部的气缸连通部分 以允许将吸入气体引入其中。
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公开(公告)号：US4897489A
公开(公告)日：1990-01-30
申请号：US58265
申请日：1987-05-21
Applicant: Kouichi Yoshioka , Setsuo Harada , Michihiko Ochiai , Hirotomo Masuya
Inventor： Kouichi Yoshioka , Setsuo Harada , Michihiko Ochiai , Hirotomo Masuya
IPC: A61K38/00 , C07D413/04 , C07D413/14 , C07D417/14 , C07D521/00 , C07F7/08 , C07F7/10 , C07F9/6539 , C07F9/6558 , C07K5/06 , C07K5/078
CPC classification number: C07D231/12 , C07D233/56 , C07D249/08 , C07D413/04 , C07D413/14 , C07D417/14 , C07F7/0812 , C07F7/10 , C07F9/65395 , C07F9/65586 , C07K5/06139 , C07K5/06191 , A61K38/00
Abstract: The compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, amino, isonitrile or an organic residue bonded through nitrogen; R.sup.2 is carboxy or a group derivable therefrom; X is hydrogen, methoxy, formylamino, alkyl which may be substituted, alkylthio in which the sulfur atom may be oxidized or azido, or forms a double bond together with the adjacent carbon atom; provided that when R.sup.1 is acetylamino or amino and X is hydrogen, R.sup.2 is not para-nitrobenzyloxycarbonyl or benzhydryloxycarbonyl, or a pharmaceutically acceptable salt thereof, exhibit excellent antimicrobial activity, and are utilized as antimicrobial agents.
Abstract translation: 下式的化合物：其中R 1是氢，氨基，异腈或通过氮键合的有机残基; R2是羧基或可从其衍生的基团; X是氢，甲氧基，甲酰基氨基，可以被取代的烷基，其中硫原子可以被氧化或叠氮基的烷硫基，或与相邻碳原子一起形成双键; 条件是当R1为乙酰氨基或氨基且X为氢时，R2不为对硝基苄氧羰基或二苯甲氧基羰基或其药学上可接受的盐，具有优异的抗微生物活性，并用作抗微生物剂。
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公开(公告)号：US4667027A
公开(公告)日：1987-05-19
申请号：US681783
申请日：1984-12-14
Applicant: Setsuo Harada , Yukimasa Nozaki , Hideo Ono
Inventor： Setsuo Harada , Yukimasa Nozaki , Hideo Ono
IPC: C07D501/28 , C07D501/57 , C12P35/06 , C12P35/08 , A61K31/545 , C07D501/40
Abstract: A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.
Abstract translation: 下式的化合物：其中R1代表氢或甲酰氨基，R2是选自丝氨酸和丙氨酸的氨基酸残基，或这些氨基酸中的至少一个的肽或氢，R3 代表通过培养属于黄单胞菌属的微生物产生的-NH-C（= NH）-NH 2或-CH 2 NH 2或其盐可用作抗细菌感染性疾病的治疗剂。
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公开(公告)号：US4007267A
公开(公告)日：1977-02-08
申请号：US562935
申请日：1975-03-28
Applicant: Toyokazu Kishi , Takashi Iwasa , Taiki Kusaka , Setsuo Harada
Inventor： Toyokazu Kishi , Takashi Iwasa , Taiki Kusaka , Setsuo Harada
CPC classification number: C07G11/00 , A01N63/02 , C12P1/06 , Y10S435/886
Abstract: A novel antibiotic B-98891, which is produced by culturing a strain of microorganisms belonging to the genus Streptomyces, shows remarkable combatting effect against microorganisms causing plant diseases. Compositions containing the antibiotic are useful for controlling diseases in plants with less undesirable side effects.
Abstract translation: 通过培养属于链霉菌属的微生物菌株产生的新型抗生素B-98891对引起植物病害的微生物显示出显着的抗击作用。 含有抗生素的组合物可用于控制具有较少不良副作用的植物中的疾病。
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Patent Agency Ranking
公开(公告)号：US20060192723A1
公开(公告)日：2006-08-31
申请号：US10562928
申请日：2004-06-25
Applicant: Setsuo Harada , Tadashi Ezaki
Inventor： Setsuo Harada , Tadashi Ezaki
IPC: H01Q7/00
CPC classification number: H01Q21/28 , H01Q1/2216 , H01Q1/2225 , H01Q1/243 , H01Q7/00
Abstract: Disclosed is a data communication apparatus for non-contact data communication using electromagnetic induction. At least a portion of a conductor 5a of the loop coil antenna (5) of the data communication apparatus, adapted for non-contact data communication, exploiting electromagnetic induction, is arranged for extending along the lateral side of an enclosure (2a) for equalizing the sensitivity of the loop coil antenna (5) across both major surfaces of the enclosure (2a).
Abstract translation: 公开了一种使用电磁感应的非接触式数据通信的数据通信装置。 数据通信设备的环形线圈天线（5）的导体5a的至少一部分适于非接触式数据通信，利用电磁感应被布置成沿着外壳（2a）的侧面延伸， 用于均衡环形线圈天线（5）在外壳（2a）的两个主表面上的灵敏度。
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公开(公告)号：US5854407A
公开(公告)日：1998-12-29
申请号：US475557
申请日：1995-06-07
Applicant: Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
Inventor： Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
Abstract: Disclosed are (1) a structurally novel 6,9-hemiacetal- erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions br a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
Abstract translation: 公开了（1）结构上新的6,9-半缩醛红霉素衍生物，其在14位和15位的至少一个位上具有羟基，其盐具有优异的胃肠功能促进作用，毒性低 ; （2）制备在14位和15位的至少一个位置具有羟基的6,9-半缩醛红霉素衍生物或其盐的方法，该方法包括使6,9-半缩醛红霉素衍生物或 其与生物体衍生的氧化酶的盐; 和（3）包含在14位和15位中的至少一个具有羟基的6,9-半缩醛红霉素衍生物或其盐的胃肠功能促进剂。
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公开(公告)号：US5470961A
公开(公告)日：1995-11-28
申请号：US33777
申请日：1993-03-19
Applicant: Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
Inventor： Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
Abstract: Disclosed are (1) a structurally novel 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
Abstract translation: 公开了（1）在14位和15位中的至少一个上具有羟基的结构新颖的6,9-半缩醛红霉素衍生物或其盐，其具有优异的胃肠功能促进作用并且毒性低 ; （2）制备在14位和15位的至少一个位置具有羟基的6,9-半缩醛红霉素衍生物或其盐的方法，该方法包括使6,9-半缩醛红霉素衍生物或 其与生物体衍生的氧化酶的盐; 和（3）包含在14位和15位中的至少一个具有羟基的6,9-半缩醛红霉素衍生物或其盐的胃肠功能促进剂。
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公开(公告)号：US4971965A
公开(公告)日：1990-11-20
申请号：US344391
申请日：1989-04-28
Applicant: Hideo Ono , Yasunori Funabashi , Setsuo Harada
Inventor： Hideo Ono , Yasunori Funabashi , Setsuo Harada
IPC: C12P17/10 , A61K31/505 , A61K31/55 , A61P31/04 , A61P35/00 , C07D239/22 , C07D243/08 , C12N1/20 , C12P13/02 , C12P17/12 , C12R1/01
CPC classification number: C07D239/22 , C07D243/08 , C12P13/02
Abstract: Novel antibiotics TAN-1057 represented by the formula: ##STR1## wherein, the absolute configuration at (A) is R or S; R.sub.1 is hydrogen and both R.sub.2 and R.sub.3 taken together form a chemical bond, or R.sub.3 is hydrogen and both R.sub.1 and R.sub.2 taken together form a chemical bond; were produced by microorganisms belonging to the genus Flexibacter. TAN-1057 strongly inhibit the growth of pathogenic microorganisms and malignant tumors, thus being useful as therapeutic agents of infectious diseases or antitumor agents.
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公开(公告)号：US4816559A
公开(公告)日：1989-03-28
申请号：US71264
申请日：1987-07-08
Applicant: Setsuo Harada , Hideo Ono , Nozomi Katayama
Inventor： Setsuo Harada , Hideo Ono , Nozomi Katayama
IPC: A61K38/00 , A61K33/26 , A61P31/04 , C07K1/02 , C07K1/113 , C07K7/06 , C07K14/195 , C07K14/41 , C12N1/20 , C12P21/02 , C12P21/04 , C12R1/39 , C07K7/50 , C07K1/12 , C12P21/00
CPC classification number: C12R1/385 , C07K7/06 , A61K38/00 , Y10S930/19 , Y10S930/27
Abstract: The iron-containing biologically active peptide TAN-866 produced by microorganisms belonging to the genus Pseudomonas and its iron free compounds have antibacterial activity mainly against gram-negative bacteria. These peptides can be used as a therepeutic agent for bacterial infections in mammals, domestic fowl, etc., caused by Pseudomonas aeruginosa. Further, TAN-866 and its deacyl compounds are also promising as the starting materials and intermediates for the synthesis of novel products.
Abstract translation: 由属于假单胞菌属的微生物及其无铁化合物产生的含铁生物活性肽TAN-866具有主要抗革兰氏阴性细菌的抗菌活性。 这些肽可以用作由铜绿假单胞菌引起的哺乳动物，家禽等细菌感染的一种。 此外，TAN-866及其脱酰基化合物也是合成新产品的原料和中间体。
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