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公开(公告)号：US08478413B2
公开(公告)日：2013-07-02
申请号：US13192256
申请日：2011-07-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/36139 , A61N1/36178
摘要： A system and associated method deliver a respiration therapy. Stimulation pulses are delivered to activate a right portion of a patient's diaphragm and to activate a left portion of a patient's diaphragm. A control processor determines dyssynchrony of a respiratory response to the stimulation pulses and adjusts a stimulation control parameter controlling the delivering of the stimulation pulses in response to dyssynchrony of the respiratory response.
摘要翻译： 系统和相关方法提供呼吸治疗。 输送刺激脉冲以激活患者隔膜的右侧部分并激活患者隔膜的左侧部分。 控制处理器确定对刺激脉冲的呼吸响应的不同步，并且调整响应于呼吸响应的不同步来控制刺激脉冲的传递的刺激控制参数。
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12.发明授权公开(公告)号：US08954160B2
公开(公告)日：2015-02-10
申请号：US13600282
申请日：2012-08-31
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译： 用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。 发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。 处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。
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13.发明申请DETECTION OF EXTRACARDIAC STIMULATION BY A CARDIAC RHYTHM MANAGEMENT DEVICE 有权通过CARDIAC RHYTHM管理设备检测提取物刺激公开(公告)号：US20130060298A1
公开(公告)日：2013-03-07
申请号：US13600282
申请日：2012-08-31
IPC分类号： A61N1/37
CPC分类号： A61N1/36585 , A61N1/3611 , A61N1/371
摘要： A medical device system and associated method for controlling a cardiac rhythm management therapy detect extracardiac stimulation. Cardiac pacing pulses are delivered, and a cardiac electrical signal comprising myocardial depolarization and repolarization signals is acquired. A processor is configured to, responsive to the cardiac electrical signal, detect extracardiac capture due to the cardiac pacing pulse.
摘要翻译： 用于控制心律管理疗法的医疗装置系统和相关方法检测心外刺激。 发送心脏起搏脉冲，并且获取包括心肌去极化和复极信号的心电信号。 处理器被配置为响应于心脏电信号，检测由于心脏起搏脉冲引起的心外捕获。
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公开(公告)号：US07313443B2
公开(公告)日：2007-12-25
申请号：US11077242
申请日：2005-03-10
IPC分类号： A61N1/36
CPC分类号： G06F9/4812 , A61N1/362 , A61N1/37 , A61N1/37211 , A61N1/37264 , G06F8/60 , G06F9/328 , G06F9/4486
摘要： The operation of an implantable medical device executing at least one set of firmware code is modified using a hardware/firmware trap at a point of execution of the set of firmware code. A patch code for directing the implantable medical device to perform a particular task is provided for execution when the trap generates an interrupt. The operation thereafter returns to the point of execution of the set of firmware code where the interrupt was generated and execution of the set of firmware code continues in a normal manner.
摘要翻译： 执行至少一组固件代码的可植入医疗装置的操作在固件代码集合的执行点使用硬件/固件陷阱进行修改。 提供用于引导可植入医疗装置执行特定任务的补丁代码，用于当陷阱产生中断时执行。 此后的操作返回到产生中断的固件代码集合的执行点，并且固件代码集的执行以正常方式继续。
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15.发明授权Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy 有权心脏起搏模式具有改善的消隐，时机和治疗收费刺激起搏治疗方法公开(公告)号：US07142916B2
公开(公告)日：2006-11-28
申请号：US10692990
申请日：2003-10-24
申请人： D. Curtis Deno , Vincent E. Splett , Jeffrey M. Gillberg , Glenn C. Zillmer , Ruth N. Klepfer , Karen J. Kleckner
发明人： D. Curtis Deno , Vincent E. Splett , Jeffrey M. Gillberg , Glenn C. Zillmer , Ruth N. Klepfer , Karen J. Kleckner
IPC分类号： A61N1/36
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译： 本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。 这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。
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16.发明授权Arithmetic computation modifier based upon data dependent operations for SIMD architectures 失效基于SIMD架构的依赖于数据的操作的算术计算修改器
公开(公告)号：US4792894A
公开(公告)日：1988-12-20
申请号：US26913
申请日：1987-03-17
CPC分类号： G06F9/3885 , G06F15/8007 , G06F9/265 , G06F9/3842 , G06F9/3887
摘要： Arithmetic Units in an SIMD processor are configurated so that status is computed based upon arithmetic conditions. This status could reflect conditions such as "A greater than B", "A equal to zero", or "overflow". The status implemented in a SIMD processor is dependent upon the specific application of the processor. values of 0 or 1, representing status conditions of true or false are typically latched in a status latch. One of the status latch bits can then be selected through a Multiplexer, (the selecting being done by an instruction from the control unit), and is called the selected condition. This selected condition is serially shifted into a Status Shift Register. The accumulated status bits from several data computations can be built up in the Status Shift Register, where the new selected condition bit is shifted in, and all the original bits in the Status Shift Register are shifted left one place. These accumulated status conditions can then be added to the common address provided to all the Arithmetic Units. This provides the capability to modify memory addresses within the Arithmetic Units based upon data computations, and allows data dependent algorithms to be performed within a SIMD processor without the loss in efficiency found in conditional activate/deactivate schemes, since the Arithmetic Units are always active.
摘要翻译： 配置SIMD处理器中的算术单位，以便根据算术条件计算状态。 这种状态可以反映诸如“A大于B”，“A等于零”或“溢出”的条件。 在SIMD处理器中实现的状态取决于处理器的具体应用。 代表状态条件为真或假的0或1的值通常被锁存在状态锁存器中。 然后可以通过多路复用器选择状态锁存位之一（选择由来自控制单元的指令进行），并称为所选条件。 该选择的条件被顺序地移入状态移位寄存器。 来自多个数据计算的累加状态位可以在状态移位寄存器中建立，其中新选择的条件位被移入，状态移位寄存器中的所有原始位都向左移位。 然后将这些累加状态条件添加到提供给所有算术单元的公共地址。 这提供了基于数据计算来修改算术单元内的存储器地址的能力，并且允许在SIMD处理器内执行与数据相关的算法，而不会在条件激活/去激活方案中发现效率损失，因为算术单元总是处于活动状态。
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17.发明申请公开(公告)号：US20130131750A1
公开(公告)日：2013-05-23
申请号：US13301012
申请日：2011-11-21
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3686 , A61N1/3688
摘要： A medical device and associated method control the delivery of a cardiac pacing therapy by selecting first and second pacing sites along a first ventricle of a patient's heart and delivering the pacing therapy by pacing the first ventricle using the first pacing site during the periods of a first ventricular pacing mode and using the second pacing site during periods of a second ventricular pacing mode. In one embodiment, the device determines activation times at multiple sites along a ventricle in response to pacing pulses being delivered to the opposite ventricle. A first pacing site is selected in response to the activation time determination. The device delivers the pacing therapy by pacing the first ventricle using the first pacing site during periods of the first ventricular pacing mode.
摘要翻译： 医疗装置和相关联的方法通过沿着患者心脏的第一脑室选择第一和第二起搏部位来控制心脏起搏治疗的递送，并且通过在第一时间段期间使用第一起搏部位起搏第一心室来递送起搏治疗 心室起搏模式，并且在第二心室起搏模式期间使用第二起搏部位。 在一个实施例中，该装置响应于递送到相对心室的起搏脉冲，沿着心室确定多个部位的激活时间。 响应于激活时间确定选择第一起搏站点。 该装置通过在第一次心室起搏模式期间使用第一起搏部位起搏第一脑室来进行起搏治疗。
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公开(公告)号：US20130030492A1
公开(公告)日：2013-01-31
申请号：US13192713
申请日：2011-07-28
IPC分类号： A61N1/37
CPC分类号： A61N1/371 , A61N1/3684 , A61N1/3686 , A61N1/3712
摘要： An implantable device and associated method detect anodal capture during electrical stimulation. A first pacing pulse is delivered using a first cathode and a first anode. A second pacing pulse is delivered using the first cathode and a second anode. A first response to the first pacing pulse and a second response to the second pacing pulse are measured. Anodal capture of the first pacing pulse at the first anode is detected in response to a first difference between the first response and the second response.
摘要翻译： 可植入装置和相关方法在电刺激期间检测阳极捕获。 使用第一阴极和第一阳极传送第一起搏脉冲。 使用第一阴极和第二阳极传送第二起搏脉冲。 测量对第一起搏脉冲的第一响应和对第二起搏脉冲的第二响应。 响应于第一响应和第二响应之间的第一差异来检测在第一阳极处的第一起搏脉冲的阳极捕获。
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公开(公告)号：US20130030491A1
公开(公告)日：2013-01-31
申请号：US13192697
申请日：2011-07-28
IPC分类号： A61N1/362
CPC分类号： A61N1/3712
摘要： An implantable device and associated method discriminate between cathodal and anodal capture during electrical stimulation. A control response to a pacing pulse delivered using a candidate cathode electrode and a universal anode and responses to bipolar pacing pulses delivered using candidate bipoles including the candidate cathode are measured. Responsive to the control response meeting a threshold response, the control response is classified as normal and each of the responses for the candidate bipoles are compared to the control response. The responses for the candidate bipoles are each classified based on the comparison.
摘要翻译： 可植入装置和相关方法在电刺激期间区分阴极和阳极捕获。 测量使用候选阴极电极和通用阳极传送的起搏脉冲的控制响应以及使用包括候选阴极的候选双极传送的双极起搏脉冲的响应。 响应于满足阈值响应的控制响应，将控制响应分类为正常，并将候选双极的每个响应与控制响应进行比较。 根据比较对候选双极的响应进行分类。
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公开(公告)号：US20100286541A1
公开(公告)日：2010-11-11
申请号：US12463470
申请日：2009-05-11
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/02405 , A61B5/726 , A61N1/3702
摘要： Techniques are described for detecting conduction abnormalities in a heart of a patient. In particular, an IMD may be configured to obtain electrical signals corresponding to cardiac activity of the heart of the patient and periodically analyze a most recent electrical signal of the obtained electrical signals to detect an electrical conduction abnormality of the heart. The IMD adjusts a frequency at which the most recent electrical signal is analyzed based on at least one physiological parameter of the patient. For example, the IMD may increase the frequency at which the most recent electrical signal is analyzed when a heart rate parameter has significantly changed and the number of detected premature ventricular contractions (PVCs) is greater than or equal to a threshold number. In this manner, the most recent electrical signal is analyzed at a higher frequency in situations in which conduction abnormalities are more likely.
摘要翻译： 描述了用于检测患者心脏中的传导异常的技术。 特别地，可以将IMD配置为获得对应于患者心脏的心脏活动的电信号，并且周期性地分析所获得的电信号的最新电信号以检测心脏的电传导异常。 IMD基于患者的至少一个生理参数来调整分析最近的电信号的频率。 例如，当心率参数已经显着改变并且检测到的早产性心室收缩（PVC）的数量大于或等于阈值数量时，IMD可以增加最近的电信号被分析的频率。 以这种方式，在导电异常更可能的情况下，以更高的频率分析最新的电信号。
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